Implementation of Motor Function Measure score percentile curves - Predicting motor function loss in Duchenne muscular dystrophy
| العنوان: | Implementation of Motor Function Measure score percentile curves - Predicting motor function loss in Duchenne muscular dystrophy |
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| المؤلفون: | Patricia Hafner, Simone Schmidt, Sabine Schädelin, Pascal Rippert, Dalil Hamroun, Solenn Fabien, Bettina Henzi, Niveditha Putananickal, Daniela Rubino-Nacht, Carole Vuillerot, Dirk Fischer, Stéphanie Fontaine-Carbonnel, Camille De Montferrand, Sylvie Ragot-Mandry, Stéphane Chabrier, Manuella Fournier Mehouas, Hélène Rauscent, Claude Cances, François Rivier, Jon Andoni Urtizberea, Sylviane Peudenier, Sylvain Brochard, Emmanuelle Lagrue |
| المساهمون: | Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University of Basel (Unibas), Hospices Civils de Lyon (HCL), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MFM registry Study Group: Stéphanie Fontaine-Carbonnel, Camille De Montferrand, Sylvie Ragot-Mandry, Stéphane Chabrier, Manuella Fournier Mehouas, Hélène Rauscent, Claude Cances, François Rivier, Jon Andoni Urtizberea, Sylviane Peudenier, Sylvain Brochard, Emmanuelle Lagrue, MORNET, Dominique |
| المصدر: | European Journal of Paediatric Neurology European Journal of Paediatric Neurology, Elsevier, 2022, 36, pp.78-83. ⟨10.1016/j.ejpn.2021.11.004⟩ European Journal of Paediatric Neurology, 2022, 36, pp.78-83. ⟨10.1016/j.ejpn.2021.11.004⟩ |
| بيانات النشر: | HAL CCSD, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Disease progression, Adolescent, [SDV]Life Sciences [q-bio], General Medicine, Duchenne, Muscular dystrophy, Reference values, [SDV] Life Sciences [q-bio], Muscular Dystrophy, Duchenne, Neuromuscular diseases, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Humans, Neurology (clinical), Motor skills disorder, Child, Glucocorticoids, 030217 neurology & neurosurgery, ComputingMilieux_MISCELLANEOUS |
| الوصف: | International audience; The Motor Function Measure is a standardized scoring system to evaluate motor function and monitor disease progression in neuromuscular diseases such as Duchenne muscular dystrophy. There are no available reference percentile curves for this measure. The aim of this analysis was to generate Motor Function Measure percentile curves for ambulant and non-ambulant patients affected by Duchenne Muscular Dystrophy, providing the opportunity to better evaluate the status and progression of an individual patient compared to other patients in the same age group. Data of patients aged between 6 and 15 years (819 measurements) was obtained from the international Motor Function Measure database. Age-dependent percentile curves were estimated using a "Generalized additive model for location, scale and shape" as suggested by the World Health Organisation Multicentre Growth Reference Study Group. Percentile curves for the Motor Function Measure total score and its sub-scores for patients with and without treatment with glucocorticoids are presented. Mean scores decline with age. Patients treated with glucocorticoids have higher mean values compared to glucocorticoid-naïve patients at the same age. The percentile curves with the online tool extend the clinical utility of the Motor Function Measure by facilitating the interpretation of individual standing and disease progression. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1090-3798 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c42e636720a9cf5754eefad58995e25Test https://hal.archives-ouvertes.fr/hal-03494418Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8c42e636720a9cf5754eefad58995e25 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10903798 |
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