An interaction between basolateral amygdala orexinergic and endocannabinoid systems in inducing anti-nociception in the rat formalin test
| العنوان: | An interaction between basolateral amygdala orexinergic and endocannabinoid systems in inducing anti-nociception in the rat formalin test |
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| المؤلفون: | Soghra Borneh Deli, Samira Iman Bonab, Roghaieh Khakpay, Fatemeh Khakpai, Mohammadali Hosseinpour Feyzi |
| المصدر: | Psychopharmacology. 239:3171-3184 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Pharmacology, Benzoxazoles, Orexins, Basolateral Nuclear Complex, Cannabinoids, Pain, Rats, Receptor, Cannabinoid, CB1, Orexin Receptors, Formaldehyde, Animals, Urea, Dimethyl Sulfoxide, RNA, Messenger, Naphthyridines, Rats, Wistar, Endocannabinoids, Pain Measurement |
| الوصف: | The amygdala has emerged as the main brain center for the emotional affective dimension of pain and pain modulation. In the amygdala, orexin and cannabinoid receptors are expressed in relatively high concentrations. To investigate the possible interaction between the amygdala orexin and cannabinoid systems on the modulation of inflammatory pain, we conducted formalin, rotarod, and plethysmometer tests, as well as analyzing mRNA expression of orexin and cannabinoid receptors in male rats. The basolateral amygdala (BLA) was unilaterally implanted by a guide cannula. Our results showed that, compared to saline and DMSO/saline, intra-BLA microinjection of orexin-A (50 and 100 µM) decreased flinch response in the early phase, but not in the late phase of the formalin test. However, these injections had no significant effect on the mRNA expression level of BLA, orexin receptor type-1 (Orx |
| تدمد: | 1432-2072 0033-3158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2212e8c221f35261d5c148466982f00fTest https://doi.org/10.1007/s00213-022-06199-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2212e8c221f35261d5c148466982f00f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322072 00333158 |
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