دورية أكاديمية
أعرض في EDS

Identification of Proteins with Potential Osteogenic Activity Present in the Water-Soluble Matrix Proteins from Crassostrea gigas Nacre Using a Proteomic Approach

التفاصيل البيبلوغرافية
العنوان: Identification of Proteins with Potential Osteogenic Activity Present in the Water-Soluble Matrix Proteins from Crassostrea gigas Nacre Using a Proteomic Approach
المؤلفون: Daniel V. Oliveira, Tomé S. Silva, Odete D. Cordeiro, Sofia I. Cavaco, Dina C. Simes
المصدر: The Scientific World Journal, Vol 2012 (2012)
بيانات النشر: Hindawi Limited, 2012.
سنة النشر: 2012
المجموعة: LCC:Technology
LCC:Medicine
LCC:Science
مصطلحات موضوعية: Technology, Medicine, Science
الوصف: Nacre, when implanted in vivo in bones of dogs, sheep, mice, and humans, induces a biological response that includes integration and osteogenic activity on the host tissue that seems to be activated by a set of proteins present in the nacre water-soluble matrix (WSM). We describe here an experimental approach that can accurately identify the proteins present in the WSM of shell mollusk nacre. Four proteins (three gigasin-2 isoforms and a cystatin A2) were for the first time identified in WSM of Crassostrea gigas nacre using 2DE and LC-MS/MS for protein identification. These proteins are thought to be involved in bone remodeling processes and could be responsible for the biocompatibility shown between bone and nacre grafts. These results represent a contribution to the study of shell biomineralization process and opens new perspectives for the development of new nacre biomaterials for orthopedic applications.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1537-744X
العلاقة: https://doaj.org/toc/1537-744XTest
DOI: 10.1100/2012/765909
الوصول الحر: https://doaj.org/article/268f9db12bae43d3b6841e9008e51972Test
رقم الانضمام: edsdoj.268f9db12bae43d3b6841e9008e51972
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1537744X
DOI:10.1100/2012/765909