التفاصيل البيبلوغرافية
| العنوان: |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| المؤلفون: |
Eva G Álvarez (11760464), Jonas Demeulemeester (180282), Paula Otero (11760467), Clemency Jolly (8442306), Daniel García-Souto (840785), Ana Pequeño-Valtierra (11760470), Jorge Zamora (260484), Marta Tojo (232315), Javier Temes (8658693), Adrian Baez-Ortega (3137595), Bernardo Rodriguez-Martin (8658681), Ana Oitaben (11760473), Alicia L Bruzos (8658705), Mónica Martínez-Fernández (634259), Kerstin Haase (3571088), Sonia Zumalave (8658714), Rosanna Abal (11760476), Jorge Rodríguez-Castro (8599905), Aitor Rodriguez-Casanova (6920966), Angel Diaz-Lagares (460733), Yilong Li (277008), Keiran M Raine (9072539), Adam P Butler (9072548), Iago Otero (5859923), Atsushi Ono (775522), Hiroshi Aikata (128663), Kazuaki Chayama (128675), Masaki Ueno (121130), Shinya Hayami (677126), Hiroki Yamaue (277099), Kazuhiro Maejima (677125), Miguel G Blanco (8658708), Xavier Forns (106986), Carmen Rivas (201317), Juan Ruiz-Bañobre (11760479), Sofía Pérez-del-Pulgar (106977), Raúl Torres-Ruiz (5340101), Sandra Rodriguez-Perales (11760482), Urtzi Garaigorta (11721584), Peter J Campbell (8155905), Hidewaki Nakagawa (128309), Peter Van Loo (9838), Jose MC Tubio (8658750) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Ecology,Evolution & Ethology, Computational & Systems Biology, Tumour Biology, Genetics & Genomics, Human Biology & Physiology, Van Loo FC001202 |
| الوصف: |
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deletions. This aberrant mutational mechanism, present in at least 8% of all HCC tumours, can provide the driver rearrangements that a cancer clone requires to survive and grow, including loss of relevant tumour suppressor genes. Most of these events are clonal and occur early during liver cancer evolution. Real-time timing estimation reveals some HBV-mediated rearrangements occur as early as two decades before cancer diagnosis. Overall, these data underscore the importance of characterising liver cancer genomes for patterns of HBV integration. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Aberrant_integration_of_Hepatitis_B_virus_DNA_promotes_major_restructuring_of_human_hepatocellular_carcinoma_genome_architecture/17086349Test |
| DOI: |
10.25418/crick.17086349.v1 |
| الإتاحة: |
https://doi.org/10.25418/crick.17086349.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.635A6B2C |
| قاعدة البيانات: |
BASE |
