المؤلفون: Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele

المصدر: SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)

مصطلحات موضوعية: Mechanistic screening, Slow-onset inhibition, Irreversible inhibition, Mechanism-of-action, Data analysis, Drug screening, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2472555222136956Test; https://doaj.org/toc/2472-5552Test

الوصول الحر: https://doaj.org/article/a2126a1a1f8f429598c4f15e9ed9a831Test

المؤلفون: Puneet Khurana (7258037), Lisa McWilliams (3115182), Jonathan Wingfield (1613578), Derek Barratt (8921054), Bharath Srinivasan (1663486)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences not elsewhere classified, kinetics, progress curve analysis, FLIPR Tetra, high-throughput screening, covalent inhibition, slow-onset inhibition, association rate, dissociation rate, structure–kinetic relationship

العلاقة: https://figshare.com/articles/journal_contribution/sj-pdf-1-jbx-10_1177_24725552211000676_Supplemental_material_for_A_Novel_High-Throughput_FLIPR_Tetra_Based_Method_for_Capturing_Highly_Confluent_Kinetic_Data_for_Structure_Kinetic_Relationship_Guided_Early_Drug_Discovery/14354857Test

الإتاحة: https://doi.org/10.25384/sage.14354857.v1Test

المؤلفون: Moulkrere, Bachar Rebat, Orena, Beatrice S., Mori, Giorgia, Saffon-Merceron, Nathalie, Rodriguez, Frederic, Lherbet, Christian, Belkheiri, Nadji, Amari, Mohamed, Hoffmann, Pascal, Fodili, Mokhtar

مصطلحات موضوعية: Carrier Protein Reductase, Slow-Onset Inhibition, Enoyl-Acp Reductase, Mycobacterium-Tuberculosis, Molecular Docking, Ucsf Chimera, Design, Substrate, Complex, Binding, 3000 Pharmacology, Toxicology and Pharmaceutics, 1605 Organic Chemistry

العلاقة: orcid:0000-0003-3469-5632

الإتاحة: https://doi.org/10.1007/s00044-017-2064-xTest
https://espace.library.uq.edu.au/view/UQ:a7a4684Test

المؤلفون: Καλλία-Ραυτοπούλου, Σοφία

مصطلحات موضوعية: Antibiotics, INHIBITORS OF RIBOSOMAL PEPTIDYLTRANSFERASE, LINCOMYCIN, RIBOSOMAL PEPTIDE BOND FORMATION, SLOW-BINDING INHIBITORS, SLOW-ONSET INHIBITION, Αντιβιοτικά, ΒΙΟΣΥΝΘΕΣΗ ΠΕΠΤΙΔΙΚΟΥ ΔΕΣΜΟΥ, ΒΡΑΔΕΩΣ ΠΡΟΣΔΕΝΟΜΕΝΟΣ ΑΝΑΣΤΟΛΕΑΣ, ΛΙΝΚΟΜΥΚΙΝΗ, Πεπτιδυλοτρανσφεράση, Φυσικές Επιστήμες, Βιολογία, Natural Sciences, Biological Sciences

العلاقة: http://hdl.handle.net/10442/hedi/2027Test

الإتاحة: https://doi.org/10.12681/eadd/2027Test
http://hdl.handle.net/10442/hedi/2027Test

المؤلفون: Li, Huei-Jiun

المساهمون: Tonge, Peter J, Department of Chemistry

مصطلحات موضوعية: Biochemistry--Chemistry, Anthranilate synthase, Catalytic mechanism, Crystal structure, Enoyl reductase, Naphthoate synthase, Slow-onset inhibition

وصف الملف: Electronic Resource; application/pdf

العلاقة: StonyBrookUniversityETDPageEmbargo_20130517082608_116839; http://hdl.handle.net/1951/60235Test

الإتاحة: http://hdl.handle.net/1951/60235Test

المؤلفون: Pan, Pan

المساهمون: Tonge, Peter J, Department of Chemistry

مصطلحات موضوعية: Chemistry, Drug development, InhA, SAR, Slow-onset inhibition

وصف الملف: Electronic Resource; application/pdf

العلاقة: Pan_grad.sunysb_0771E_11060; http://hdl.handle.net/1951/59815Test

الإتاحة: http://hdl.handle.net/1951/59815Test