مراجعة
Drug delivery to and through the skin.
| العنوان: | Drug delivery to and through the skin. |
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| المؤلفون: | Guy, Richard H |
| المصدر: | Drug Deliv Transl Res ; ISSN:2190-3948 ; Volume:14 ; Issue:8 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Drug delivery technology, Skin barrier function, Skin penetration enhancement – chemical, Skin penetration enhancement – physical, Topical and transdermal drug delivery, Topical formulations and metamorphosis |
| الوصف: | Drug delivery technology has advanced significantly over >50 years, and has produced remarkable innovation, countless publications and conferences, and generations of talented and creative scientists. However, a critical review of the current state-of-the-art reveals that the translation of clever and sophisticated drug delivery technologies into products, which satisfy important, unmet medical needs and have been approved by the regulatory agencies, has - given the investment made in terms of time and money - been relatively limited. Here, this point of view is illustrated using a case study of technology for drug delivery into and through the skin and aims: to examine the historical development of this field and the current state-of-the-art; to understand why the translation of drug delivery technologies into products that improve clinical outcomes has been quite slow and inefficient; and to suggest how the impact of technology may be increased and the process of concept to approved product accelerated. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s13346-024-01614-wTest; https://pubmed.ncbi.nlm.nih.gov/38837116Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208237Test/ |
| DOI: | 10.1007/s13346-024-01614-w |
| الإتاحة: | https://doi.org/10.1007/s13346-024-01614-wTest https://pubmed.ncbi.nlm.nih.gov/38837116Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208237Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.3BEF1AC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13346-024-01614-w |
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