دورية أكاديمية
One-Year Real-World Study on Comparison among Different Continuous Subcutaneous Insulin Infusion Devices for the Management of Pediatric Patients with Type 1 Diabetes: The Supremacy of Hybrid Closed-Loop Systems
| العنوان: | One-Year Real-World Study on Comparison among Different Continuous Subcutaneous Insulin Infusion Devices for the Management of Pediatric Patients with Type 1 Diabetes: The Supremacy of Hybrid Closed-Loop Systems |
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| المؤلفون: | Bruno Bombaci, Stefano Passanisi, Angela Alibrandi, Giulia D’Arrigo, Serena Patroniti, Simona Averna, Giuseppina Salzano, Fortunato Lombardo |
| المصدر: | International Journal of Environmental Research and Public Health, Vol 19, Iss 10293, p 10293 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | continuous glucose monitoring, glycemic variability, insulin pumps, time in range, therapy, Medicine |
| الوصف: | Since their advent in daily clinical practice, continuous subcutaneous insulin infusion (CSII) systems have been increasingly improved, leading to a high percentage of both adult and pediatric patients with diabetes now using insulin pumps. Different types of CSII systems are currently available, which are characterized by different settings and technical features. This longitudinal observational study aims to evaluate real-word glycemic outcomes in children and adolescents with type 1 diabetes using three different CSII devices: hybrid closed-loop (HCL) systems, predictive low glucose (PLGS) systems, and non-automated insulin pumps. The secondary objective was to identify clinical variables that may significantly influence the achievement of therapeutic goals in our study cohort. One-hundred-and-one patients on CSII therapy attending our pediatric diabetes center were enrolled. When compared with the non-automated group, patients using HCL systems showed higher levels of time in target glucose range ( p = 0.003) and lower glucose variability ( p = 0.008). Similarly, we found significantly better glucose metrics in HCL users in comparison to PLGS patients (time in range p = 0.008; coefficient of variation p = 0.009; time above 250 mg/dL p = 0.007). Multiple linear regression models showed that HCL systems (time in range p < 0.001) and high daily percentage of glycemic sensor use (time in range p = 0.031) are predictors for good glycemic control. The introduction and increasing availability of novel technologies for diabetes represent a promising strategy to improve glycemic control and quality of life in pediatric patients with type 1 diabetes. Our real-world data confirm the superiority of HCL systems in terms of improvement of time spent in the target glucose range, prevention of hypoglycemia, and reduction of glycemic variability. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1660-4601 1661-7827 |
| العلاقة: | https://www.mdpi.com/1660-4601/19/16/10293Test; https://doaj.org/toc/1661-7827Test; https://doaj.org/toc/1660-4601Test; https://doaj.org/article/d80c830386404fc79a374e6fd641d075Test |
| DOI: | 10.3390/ijerph191610293 |
| الإتاحة: | https://doi.org/10.3390/ijerph191610293Test https://doaj.org/article/d80c830386404fc79a374e6fd641d075Test |
| رقم الانضمام: | edsbas.A483BE92 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16604601 16617827 |
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| DOI: | 10.3390/ijerph191610293 |