المؤلفون: Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7547983126794fc0a17cf1c4d462a298Test

المؤلفون: Seung Tae Kim, Sujin Lee, Minhwa Park, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Young Suk Park, Won Ki Kang, Esha A. Gangolli, Hyeongchan Shin, Kyoung-Mee Kim, Simon J. Hollingsworth, Peter G.S. Mortimer, Jeeyun Lee

المصدر: Translational Oncology, Vol 12, Iss 4, Pp 597-601 (2019)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S193652331830367XTest; https://doaj.org/toc/1936-5233Test

الوصول الحر: https://doaj.org/article/b406b35b84a64e659486a5ba09d5da21Test

المؤلفون: Guenther G. Steger, Anitra Fielding, Nigel Baker, Patricia A. Ganz, Norman Wolmark, Joseph P. Costantino, Barbro Linderholm, Larissa A. Korde, Robin McConnell, Jennifer Marie Suga, Susan M. Domchek, Karen A. Gelmon, Greg Yothers, Amal Arahmani, Richard D. Gelber, Sibylle Loibl, Hanna Bandos, Elżbieta Senkus, Giuseppe Viale, Debora Fumagalli, Judy Garber, Judith Balmaña, Christine Campbell, Sunil R. Lakhani, Vassiliki Karantza, Tomasz Huzarski, Zbigniew Nowecki, Andrew W. Pippas, Simon J. Hollingsworth, Peter Lucas, Eleanor McFadden, Zhimin Shao, Rita K. Schmutzler, Charles E. Geyer, Priya Rastogi, Bella Kaufman, Andrew Tutt, Evandro de Azambuja, Martine Piccart

المصدر: New England Journal of Medicine, 384(25), 2394-2405. MASSACHUSETTS MEDICAL SOC
The New England journal of medicine, vol 384, iss 25

مصطلحات موضوعية: medicine.medical_treatment, Synthetic lethality, Medical and Health Sciences, Poly (ADP-Ribose) Polymerase Inhibitor, Piperazines, chemistry.chemical_compound, ErbB-2, Adjuvant, Mastectomy, Polymerase, Cancer, biology, General Medicine, Middle Aged, 6.1 Pharmaceuticals, Female, Receptor, Adult, Clinical Trials and Supportive Activities, Breast Neoplasms, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Disease-Free Survival, Olaparib, Breast cancer, Double-Blind Method, Clinical Research, General & Internal Medicine, Breast Cancer, medicine, Humans, Chemotherapy, Germ-Line Mutation, business.industry, Evaluation of treatments and therapeutic interventions, BRCA1, medicine.disease, BRCA2, Good Health and Well Being, Genes, chemistry, biology.protein, Cancer research, Phthalazines, Digestive Diseases, Homologous recombination, business, OlympiA Clinical Trial Steering Committee and Investigators

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e52f9a2de90257dee369f76dcfb6c2Test
https://doi.org/10.1056/nejmoa2105215Test

المؤلفون: Aleksandra Markovets, Kyung Kim, Barrett Nuttall, J. Carl Barrett, Simon J. Hollingsworth, Jung Yong Hong, Jeeyun Lee, Se Hoon Park, Kyoung-Mee Kim, Esha A. Gangolli, Seung Tae Kim, Peter G. Mortimer, Melanie M. Frigault

المصدر: JCO Precision Oncology. :222-232

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, business.industry, Cancer, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Acquired resistance, Oncology, Savolitinib, 030220 oncology & carcinogenesis, medicine, Cancer research, business, Gene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::81ed9259005ba3a65adc4d152550aa6cTest
https://doi.org/10.1200/po.19.00386Test

المؤلفون: Robert E. Godin, Jin Seok Ahn, Joon Ho Shim, Myung-Ju Ahn, Keunchil Park, Hyun Ae Jung, Peter S. Mortimer, Jong-Mu Sun, Sehhoon Park, Woong-Yang Park, Simon Smith, Se-Hoon Lee, Simon J. Hollingsworth, Heejung (Rosa) Kim

المصدر: Cancer. 126:4002-4012

مصطلحات موضوعية: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, Morpholines, medicine.medical_treatment, Pyrimidinones, Neutropenia, Gene mutation, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Humans, 030212 general & internal medicine, Adverse effect, Cyclin-Dependent Kinase Inhibitor p16, Aged, Platinum, Aged, 80 and over, Chemotherapy, business.industry, Gene Amplification, Cancer, Common Terminology Criteria for Adverse Events, Middle Aged, medicine.disease, Small Cell Lung Carcinoma, Progression-Free Survival, Confidence interval, Pyrimidines, Rapamycin-Insensitive Companion of mTOR Protein, 030220 oncology & carcinogenesis, Benzamides, Pyrazoles, Biomarker (medicine), Female, Neoplasm Recurrence, Local, Tumor Suppressor Protein p53, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f140f2db5474e86cd747b76efa9e7cTest
https://doi.org/10.1002/cncr.33048Test

المؤلفون: Byung-Hoon Min, Jung Yong Hong, Jeeyun Lee, Peter G. Mortimer, Jun Ho Lee, Jae J. Kim, Sung Kim, Justin I. Odegaard, Hyuk Lee, Kyung Kim, Nayoung K.D. Kim, Young Suk Park, Kyoung-Mee Kim, Min Gew Choi, Jae Moon Bae, Ji Yeong An, Se Hoon Park, Sally Luke, Young Saing Kim, Yang Won Min, Joon Oh Park, Jinchul Kim, Jung Hun Kang, Elizabeth A. Harrington, Jun Ho Ji, Iwanka Kozarewa, Young Hwa Kim, Ho Yeong Lim, Jung Hoon Kim, Youjin Kim, Lee Ju Young, Kyoung Eun Lee, Taehyang Lee, Simon J. Hollingsworth, Sung Yong Oh, Seung Tae Kim, AmirAli Talasaz, Tae Sung Sohn, Won Ki Kang

المصدر: Cancer Discovery. 9:1388-1405

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Biopsy, medicine.medical_treatment, Clinical Decision-Making, Circulating Tumor DNA, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Medicine, Molecular Targeted Therapy, Neoplasm Metastasis, Neoplasm Staging, Chemotherapy, medicine.diagnostic_test, business.industry, Gene Expression Profiling, MEK inhibitor, Computational Biology, Disease Management, Genomics, Prognosis, Gene Expression Regulation, Neoplastic, Gene expression profiling, Clinical trial, Treatment Outcome, 030104 developmental biology, Savolitinib, 030220 oncology & carcinogenesis, Selumetinib, Biomarker (medicine), business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9dda5b823f58f363604cba7e1946f6Test
https://doi.org/10.1158/2159-8290.cd-19-0442Test

المؤلفون: Brunella Felicetti, Paul Frewer, Juanita Lopez, Anthony El-Khouiery, Glen Clack, Christine Stephens, Simon J. Hollingsworth, Matthew G Krebs, Alan Lau, Andrew Goldwin, Alienor Berges, Jean-Charles Soria, Gemma N Jones, Sophie Postel-Vinay, Itziar Irurzun-Arana, Emma Dean, Sy Amy Cheung, Timothy A. Yap, Andrew J. Pierce, Simon Smith

المصدر: Yap, T, Krebs, M, Postel-Vinay, S, El-Khouiery, A, Soria, J-C, Lopez, J, Berges, A, Cheung, S Y A, Irurzan-Arana, I, Goldwin, A, Felicetti, B, Jones, G, Lau, A, Frewer, P, Pierce, A, Clack, G, Stephens, C, Smith, S, Dean, E J & Hollingsworth, S J 2021, ' Ceralasertib (AZD6738), an oral ATR kinase inhibitor, in combination with carboplatin in patients with advanced solid tumors: a Phase I study ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-21-1032Test

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Indoles, Neutropenia, Maximum Tolerated Dose, Anemia, Morpholines, Ataxia Telangiectasia Mutated Proteins, Gastroenterology, Carboplatin, chemistry.chemical_compound, Pharmacokinetics, Internal medicine, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Adverse effect, Protein Kinase Inhibitors, Sulfonamides, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Nuclear Proteins, Common Terminology Criteria for Adverse Events, medicine.disease, Thrombocytopenia, Pyrimidines, Oncology, Tolerability, chemistry, Pharmacodynamics, Sulfoxides, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5158d7388a6bd09605d2ca9977160f12Test
https://pubmed.ncbi.nlm.nih.gov/34301752Test

المؤلفون: Melanie M, Frigault, Aleksandra, Markovets, Barrett, Nuttall, Kyoung-Mee, Kim, Se Hoon, Park, Esha A, Gangolli, Peter G S, Mortimer, Simon J, Hollingsworth, Jung Yong, Hong, Kyung, Kim, Seung Tae, Kim, J Carl, Barrett, Jeeyun, Lee

المصدر: JCO Precision Oncology

مصطلحات موضوعية: Original Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a4ab20336eea4fa5bade2bd3f7dbb964Test
https://pubmed.ncbi.nlm.nih.gov/32923890Test

المؤلفون: Mark J. O'Connor, Stephen Fawell, Barry R. Davies, Joanne Wilson, Valeria Follia, Paul W. G. Wijnhoven, M. Raymond V. Finlay, Mercedes Vazquez-Chantada, Neil H. James, Elaine Cadogan, Aaron Smith, Paul Farrington, Simon J. Hollingsworth, Lenka Oplustil O'Connor, Emma Dean, Ankur Karmokar, Sophie E. Willis, Frederick W. Goldberg, Gillian M. Lamont, Antonio Ramos-Montoya, Stephanie Ling, D. Beattie, Jacqueline H. L. Fok, Jonathan Cairns, Jenni Nikkilä

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Lung Neoplasms, General Physics and Astronomy, Apoptosis, DNA-Activated Protein Kinase, Radiation Tolerance, Piperazines, Polyethylene Glycols, chemistry.chemical_compound, Mice, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, lcsh:Science, Multidisciplinary, Antibiotics, Antineoplastic, Drug Synergism, 030220 oncology & carcinogenesis, PARP inhibitor, Growth inhibition, medicine.symptom, Clinical pharmacology, DNA damage, Science, Drug development, Poly(ADP-ribose) Polymerase Inhibitors, General Biochemistry, Genetics and Molecular Biology, Article, Genomic Instability, Olaparib, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Cell Proliferation, Pyrans, Radiotherapy, General Chemistry, Triazoles, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, Mechanism of action, A549 Cells, Doxorubicin, Purines, Cancer research, Phthalazines, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2343caeeb96aedc19f4ab9d664878eTest
http://europepmc.org/articles/PMC6838110Test

المؤلفون: Brian Dougherty, Francisco Cruzalegui, Naomi Laing, J. Carl Barrett, Robert McEwen, Jonathan R. Dry, Darren Hodgson, T. Hedley Carr, Zara Ghazoui, Zhongwu Lai, Simon J. Hollingsworth, Justin Johnson

المصدر: Nature Reviews Cancer. 16:319-329

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Genomic profiling, General Mathematics, medicine.medical_treatment, Multiple hypotheses, Patient subgroups, MEDLINE, Pyrimidinones, Biology, Bioinformatics, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, medicine, Humans, In patient, Rapid testing, Applied Mathematics, Clinical trial, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, Pyrazoles, Tumor Suppressor Protein p53

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b289f0ab637e43072e692dc2563c129Test
https://doi.org/10.1038/nrc.2016.35Test