Expression and localization of plasminogen activator inhibitor 1 mRNA in transplant kidneys
| العنوان: | Expression and localization of plasminogen activator inhibitor 1 mRNA in transplant kidneys |
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| المؤلفون: | Simon A. Whawel, Elizabeth Thompson, Yiming Wang, Kenneth A. Fleming |
| المصدر: | The Journal of Pathology. 169:445-450 |
| بيانات النشر: | Wiley, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Graft Rejection, Male, Pathology, medicine.medical_specialty, medicine.medical_treatment, Ischemia, In situ hybridization, Kidney, Pathology and Forensic Medicine, chemistry.chemical_compound, Plasminogen Activator Inhibitor 1, Fibrinolysis, medicine, Humans, Endothelium, RNA, Messenger, In Situ Hybridization, Chemotherapy, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, Thrombosis, Transplantation, medicine.anatomical_structure, chemistry, Plasminogen activator inhibitor-1, Female, business |
| الوصف: | Fibrinolysis in renal transplant rejection has not been systematically investigated but is known to be impaired. By an in situ hybridization technique, we have studied gene expression of plasminogen activator inhibitor 1 (PAI-1) in human renal tissue showing severe acute vascular rejection (n = 8), clinically irreversible (chronic) vascular rejection (n = 3), mild vascular rejection (n = 8), parenchymal rejection (n = 4), 'normal' kidneys (n = 6), and non-rejecting kidneys (n = 6). The results showed that in 7/8 cases showing severe acute vascular rejection and in all three chronic vascular rejection cases, PAI-1 mRNA was expressed by endothelial cells of arterioles and arteries, and interstitial inflammatory cells but was not detectable in any other groups. The expression of PAI-1 was frequently associated with areas of haemorrhage. Expression of PAI-1 might be expected to promote thrombosis and ischaemia, the catastrophic consequence of severe vascular rejection. In irreversible chronic rejection, this seems to be the principal mode of action. However, our observation that there is expression of PAI-1 in areas of haemorrhage in severe acute vascular rejection may suggest an additional potentially protective role, if it were produced as a response to haemorrhage. |
| تدمد: | 1096-9896 0022-3417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7ac28e473f15cb26ea50d27ce684f4Test https://doi.org/10.1002/path.1711690410Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6b7ac28e473f15cb26ea50d27ce684f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969896 00223417 |
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