دورية أكاديمية
Genetic insights into resting heart rate and its role in cardiovascular disease.
| العنوان: | Genetic insights into resting heart rate and its role in cardiovascular disease. |
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| المؤلفون: | van de Vegte, YJ, Eppinga, RN, van der Ende, MY, Hagemeijer, YP, Mahendran, Y, Salfati, E, Smith, AV, Tan, VY, Arking, DE, Ntalla, I, Appel, EV, Schurmann, C, Brody, JA, Rueedi, R, Polasek, O, Sveinbjornsson, G, Lecoeur, C, Ladenvall, C, Zhao, JH, Isaacs, A, Wang, L, Luan, J, Hwang, S-J, Mononen, N, Auro, K, Jackson, AU, Bielak, LF, Zeng, L, Shah, N, Nethander, M, Campbell, A, Rankinen, T, Pechlivanis, S, Qi, L, Zhao, W, Rizzi, F, Tanaka, T, Robino, A, Cocca, M, Lange, L, Müller-Nurasyid, M, Roselli, C, Zhang, W, Kleber, ME, Guo, X, Lin, HJ, Pavani, F, Galesloot, TE, Noordam, R, Milaneschi, Y, Schraut, KE, den Hoed, M, Degenhardt, F, Trompet, S, van den Berg, ME, Pistis, G, Tham, Y-C, Weiss, S, Sim, XS, Li, HL, van der Most, PJ, Nolte, IM, Lyytikäinen, L-P, Said, MA, Witte, DR, Iribarren, C, Launer, L, Ring, SM, de Vries, PS, Sever, P, Linneberg, A, Bottinger, EP, Padmanabhan, S, Psaty, BM, Sotoodehnia, N, Kolcic, I, DCCT/EDIC Research Group, Arnar, DO, Gudbjartsson, DF, Holm, H, Balkau, B, Silva, CT, Newton-Cheh, CH, Nikus, K, Salo, P, Mohlke, KL, Peyser, PA, Schunkert, H, Lorentzon, M, Lahti, J, Rao, DC, Cornelis, MC, Faul, JD, Smith, JA, Stolarz-Skrzypek, K, Bandinelli, S, Concas, MP, Sinagra, G, Meitinger, T, Waldenberger, M, Sinner, MF, Strauch, K, Delgado, GE, Taylor, KD, Yao, J, Foco, L, Melander, O, de Graaf, J, de Mutsert, R, de Geus, EJC, Johansson, Å, Joshi, PK, Lind, L, Franke, A, Macfarlane, PW, Tarasov, KV, Tan, N, Felix, SB, Tai, E-S, Quek, DQ, Snieder, H, Ormel, J, Ingelsson, M, Lindgren, C, Morris, AP, Raitakari, OT, Hansen, T, Assimes, T, Gudnason, V, Timpson, NJ, Morrison, AC, Munroe, PB, Strachan, DP, Grarup, N, Loos, RJF, Heckbert, SR, Vollenweider, P, Hayward, C, Stefansson, K, Froguel, P, Groop, L, Wareham, NJ, van Duijn, CM, Feitosa, MF, O'Donnell, CJ, Kähönen, M, Perola, M, Boehnke, M, Kardia, SLR, Erdmann, J, Palmer, CNA, Ohlsson, C, Porteous, DJ, Eriksson, JG, Bouchard, C, Moebus, S, Kraft, P, Weir, DR, Cusi, D, Ferrucci, L, Ulivi, S, Girotto, G, Correa, A, Kääb, S, Peters, A, Chambers, JC, Kooner, JS, März, W, Rotter, JI, Hicks, AA, Smith, JG, Kiemeney, LALM, Mook-Kanamori, DO, Penninx, BWJH, Gyllensten, U, Wilson, JF, Burgess, S, Sundström, J, Lieb, W, Jukema, JW, Eijgelsheim, M, Lakatta, ELM, Cheng, C-Y, Dörr, M, Wong, T-Y, Sabanayagam, C, Oldehinkel, AJ, Riese, H, Lehtimäki, T, Verweij, N, van der Harst, P |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2023 |
| المجموعة: | St George's University of London: Repository |
| الوصف: | Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci. We prioritize 670 genes and in silico annotations point to their enrichment in cardiomyocytes and provide insights in their ECG signature. Two-sample Mendelian randomization analyses indicate that higher genetically predicted resting heart rate increases risk of dilated cardiomyopathy, but decreases risk of developing atrial fibrillation, ischemic stroke, and cardio-embolic stroke. We do not find evidence for a linear or non-linear genetic association between resting heart rate and all-cause mortality in contrast to our previous Mendelian randomization study. Systematic alteration of key differences between the current and previous Mendelian randomization study indicates that the most likely cause of the discrepancy between these studies arises from false positive findings in previous one-sample MR analyses caused by weak-instrument bias at lower P-value thresholds. The results extend our understanding of resting heart rate biology and give additional insights in its role in cardiovascular disease development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.ms-excel |
| اللغة: | English |
| العلاقة: | https://openaccess.sgul.ac.uk/id/eprint/115488/17/s41467-023-39521-2.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/22/41467_2023_39521_MOESM1_ESM.docxTest; https://openaccess.sgul.ac.uk/id/eprint/115488/24/41467_2023_39521_MOESM2_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/29/41467_2023_39521_MOESM3_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/34/41467_2023_39521_MOESM4_ESM.xlsxTest; https://openaccess.sgul.ac.uk/id/eprint/115488/35/41467_2023_39521_MOESM5_ESM.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/1/NCOMMS-22-22457C_Main_paper.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/6/NCOMMS-22-22457C_Figures.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/11/NCOMMS-22-22457C_Supplementary_Information.pdfTest; https://openaccess.sgul.ac.uk/id/eprint/115488/16/NCOMMS-22-22457C_Supplementary_Data.xlsxTest; van de Vegte, YJ; Eppinga, RN; van der Ende, MY; Hagemeijer, YP; Mahendran, Y; Salfati, E; Smith, AV; Tan, VY; Arking, DE; Ntalla, I; et al. van de Vegte, YJ; Eppinga, RN; van der Ende, MY; Hagemeijer, YP; Mahendran, Y; Salfati, E; Smith, AV; Tan, VY; Arking, DE; Ntalla, I; Appel, EV; Schurmann, C; Brody, JA; Rueedi, R; Polasek, O; Sveinbjornsson, G; Lecoeur, C; Ladenvall, C; Zhao, JH; Isaacs, A; Wang, L; Luan, J; Hwang, S-J; Mononen, N; Auro, K; Jackson, AU; Bielak, LF; Zeng, L; Shah, N; Nethander, M; Campbell, A; Rankinen, T; Pechlivanis, S; Qi, L; Zhao, W; Rizzi, F; Tanaka, T; Robino, A; Cocca, M; Lange, L; Müller-Nurasyid, M; Roselli, C; Zhang, W; Kleber, ME; Guo, X; Lin, HJ; Pavani, F; Galesloot, TE; Noordam, R; Milaneschi, Y; Schraut, KE; den Hoed, M; Degenhardt, F; Trompet, S; van den Berg, ME; Pistis, G; Tham, Y-C; Weiss, S; Sim, XS; Li, HL; van der Most, PJ; Nolte, IM; Lyytikäinen, L-P; Said, MA; Witte, DR; Iribarren, C; Launer, L; Ring, SM; de Vries, PS; Sever, P; Linneberg, A; Bottinger, EP; Padmanabhan, S; Psaty, BM; Sotoodehnia, N; Kolcic, I; DCCT/EDIC Research Group; Arnar, DO; Gudbjartsson, DF; Holm, H; Balkau, B; Silva, CT; Newton-Cheh, CH; Nikus, K; Salo, P; Mohlke, KL; Peyser, PA; Schunkert, H; Lorentzon, M; Lahti, J; Rao, DC; Cornelis, MC; Faul, JD; Smith, JA; Stolarz-Skrzypek, K; Bandinelli, S; Concas, MP; Sinagra, G; Meitinger, T; Waldenberger, M; Sinner, MF; Strauch, K; Delgado, GE; Taylor, KD; Yao, J; Foco, L; Melander, O; de Graaf, J; de Mutsert, R; de Geus, EJC; Johansson, Å; Joshi, PK; Lind, L; Franke, A; Macfarlane, PW; Tarasov, KV; Tan, N; Felix, SB; Tai, E-S; Quek, DQ; Snieder, H; Ormel, J; Ingelsson, M; Lindgren, C; Morris, AP; Raitakari, OT; Hansen, T; Assimes, T; Gudnason, V; Timpson, NJ; Morrison, AC; Munroe, PB; Strachan, DP; Grarup, N; Loos, RJF; Heckbert, SR; Vollenweider, P; Hayward, C; Stefansson, K; Froguel, P; Groop, L; Wareham, NJ; van Duijn, CM; Feitosa, MF; O'Donnell, CJ; Kähönen, M; Perola, M; Boehnke, M; Kardia, SLR; Erdmann, J; Palmer, CNA; Ohlsson, C; Porteous, DJ; Eriksson, JG; Bouchard, C; Moebus, S; Kraft, P; Weir, DR; Cusi, D; Ferrucci, L; Ulivi, S; Girotto, G; Correa, A; Kääb, S; Peters, A; Chambers, JC; Kooner, JS; März, W; Rotter, JI; Hicks, AA; Smith, JG; Kiemeney, LALM; Mook-Kanamori, DO; Penninx, BWJH; Gyllensten, U; Wilson, JF; Burgess, S; Sundström, J; Lieb, W; Jukema, JW; Eijgelsheim, M; Lakatta, ELM; Cheng, C-Y; Dörr, M; Wong, T-Y; Sabanayagam, C; Oldehinkel, AJ; Riese, H; Lehtimäki, T; Verweij, N; van der Harst, P (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nat Commun, 14 (1). p. 4646. ISSN 2041-1723 https://doi.org/10.1038/s41467-023-39521-2Test SGUL Authors: Strachan, David Peter |
| DOI: | 10.1038/s41467-023-39521-2 |
| الإتاحة: | https://doi.org/10.1038/s41467-023-39521-2Test https://openaccess.sgul.ac.uk/id/eprint/115488Test/ https://openaccess.sgul.ac.uk/id/eprint/115488/17/s41467-023-39521-2.pdfTest https://openaccess.sgul.ac.uk/id/eprint/115488/22/41467_2023_39521_MOESM1_ESM.docxTest https://openaccess.sgul.ac.uk/id/eprint/115488/24/41467_2023_39521_MOESM2_ESM.pdfTest https://openaccess.sgul.ac.uk/id/eprint/115488/29/41467_2023_39521_MOESM3_ESM.pdfTest https://openaccess.sgul.ac.uk/id/eprint/115488/34/41467_2023_39521_MOESM4_ESM.xlsxTest https://openaccess.sgul.ac.uk/id/eprint/115488/35/41467_2023_39521_MOESM5_ESM.pdfTest https://openaccess.sgul.ac.uk/id/eprint/115488/1/NCOMMS-22-22457C_Main_paper.pdfTest https://openaccess.sgul.ac.uk/id/eprint/115488/6/NCOMMS-22-22457C_Figures.pdfTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.2BF173B7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-39521-2 |
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