دورية أكاديمية
Multi-omics in thoracic aortic aneurysm: the complex road to the simplification
| العنوان: | Multi-omics in thoracic aortic aneurysm: the complex road to the simplification |
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| المؤلفون: | Sara Rega, Floriana Farina, Silvia Bouhuis, Silvia de Donato, Mattia Chiesa, Paolo Poggio, Laura Cavallotti, Giorgia Bonalumi, Ilaria Giambuzzi, Giulio Pompilio, Gianluca L. Perrucci |
| المصدر: | Cell & Bioscience, Vol 13, Iss 1, Pp 1-27 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Thoracic aortic aneurysm, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Abstract Background Thoracic aortic aneurysm (TAA) is a serious condition that affects the aorta, characterized by the dilation of its first segment. The causes of TAA (e.g., age, hypertension, genetic syndromes) are heterogeneous and contribute to the weakening of the aortic wall. This complexity makes treating this life-threatening aortopathy challenging, as there are currently no etiological therapy available, and pharmacological strategies, aimed at avoiding surgical aortic replacement, are merely palliative. Recent studies on novel therapies for TAA have focused on identifying biological targets and etiological mechanisms of the disease by using advanced -omics techniques, including epigenomics, transcriptomics, proteomics, and metabolomics approaches. Methods This review presents the latest findings from -omics approaches and underscores the importance of integrating multi-omics data to gain more comprehensive understanding of TAA. Results Literature suggests that the alterations in TAA mediators frequently involve members of pro-fibrotic process (i.e., TGF-β signaling pathways) or proteins associated with cell/extracellular structures (e.g., aggrecans). Further analyses often reported the importance in TAA of processes as inflammation (PCR, CD3, leukotriene compounds), oxidative stress (chromatin OXPHOS, fatty acids), mitochondrial respiration and glycolysis/gluconeogenesis (e.g., PPARs and HIF1a). Of note, more recent metabolomics studies added novel molecular markers to the list of TAA-specific detrimental mediators (proteoglycans). Conclusion It is increasingly clear that integrating data from different -omics branches, along with clinical data, is essential as well as complicated both to reveal hidden relevant information and to address complex diseases such as TAA. Importantly, recent progresses in metabolomics highlighted novel potential and unprecedented marks in TAA diagnosis and therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-3701 |
| العلاقة: | https://doaj.org/toc/2045-3701Test |
| DOI: | 10.1186/s13578-023-01080-w |
| الوصول الحر: | https://doaj.org/article/4141eb53329d41b296138e8550d9e87aTest |
| رقم الانضمام: | edsdoj.4141eb53329d41b296138e8550d9e87a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20453701 |
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| DOI: | 10.1186/s13578-023-01080-w |