دورية أكاديمية
Systematic Review of Platelet-Rich Plasma for Low Back Pain
| العنوان: | Systematic Review of Platelet-Rich Plasma for Low Back Pain |
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| المؤلفون: | Silva Machado, Edilson, Soares, Fabiano Pasqualotto, Vianna de Abreu, Ernani, de Souza, Taís Amara da Costa, Meves, Robert, Grohs, Hans, Ambach, Mary A., Navani, Annu, de Castro, Renato Bevillaqua, DH, Pozza, Caldas, José Manuel Peixoto |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Technical University of Lisbon: UTL Repository / Universidade Técnica de Lisboa |
| مصطلحات موضوعية: | Platelet-rich Plasma, Low Back Pain, Discogenic Pain, Facet Pain, Orthobiologics, Regenerative Medicine, Spinal Injection, Epidural Injection |
| الوصف: | Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Machado, E.S.; Soares, F.P.; Vianna de Abreu, E.; de Souza, T.A.d.C.; Meves, R.; Grohs, H.; Ambach, M.A.; Navani, A.; de Castro, R.B.; Pozza, D.H.; et al. Systematic Review of Platelet-Rich Plasma for Low Back Pain. Biomedicines 2023, 11, 2404. https://doi.org/10.3390/biomedicines11092404Test; http://hdl.handle.net/10400.5/30403Test |
| DOI: | 10.3390/biomedicines11092404 |
| الإتاحة: | https://doi.org/10.3390/biomedicines11092404Test http://hdl.handle.net/10400.5/30403Test |
| حقوق: | openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.ABD911C5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biomedicines11092404 |
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