دورية أكاديمية
Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws—a case series
| العنوان: | Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws—a case series |
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| المؤلفون: | Dos Anjos, RS, De Pádua Walfrido, GN, De Hollanda Valente, RO, Gueiros, LA, Carvalho, AAT, Patel, P, Porter, S, Leão, JC, Silva, IHM |
| المصدر: | Supportive Care in Cancer , 29 pp. 3311-3317. (2021) |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Osteoradionecrosis, Pentoxifylline, Radiotherapy, Tocopherol |
| الوصف: | Background: The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws. / Methods: Twenty-five patients diagnosed with osteoradionecrosis of the jaws treated with pentoxifylline 400 mg + tocopherol 400 mg three times daily (tid) were evaluated. Clinical records and image tests were reviewed. All patients were previously submitted to head and neck radiation therapy and presented with a clinical and radiographic diagnosis of osteoradionecrosis of the jaws. / Results: Following therapy with pentoxifylline and tocopherol, 76% (19/25) of the patients showed complete mucosal healing, in which 47.3% (9/19) did not undergo sequestrectomy. From this particular group, 77.7% (7/9) were in stage I and 33.3% (3/9) used the protocol for up to 3 months. Among those who underwent to sequestrectomy, complete mucosal healing was observed in 52.7% (10/19). Among these, 60% (6/10) were in stage I and 100% of the patients were using the protocol for more than 3 months. In all other patients, partial healing of the mucosa was observed since they presented advanced disease. These represented 24% of the sample (6/25), 66.6% (4/6) were in stage III, and 60% (4/6) used the protocol for over 6 months. / Conclusion: Pentoxifylline and tocopherol may provide effective management of osteoradionecrosis of the jaws, and the association with sequestrectomy may avoid major surgical procedures. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10113589/3/Porter_ORN_Pento_Final_accepted%20loaed.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10113589Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10113589/3/Porter_ORN_Pento_Final_accepted%20loaed.pdfTest https://discovery.ucl.ac.uk/id/eprint/10113589Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.D9A1217 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |