دورية أكاديمية
Deuterated Arachidonic Acid Ameliorates Lipopolysaccharide-Induced Lung Damage in Mice
| العنوان: | Deuterated Arachidonic Acid Ameliorates Lipopolysaccharide-Induced Lung Damage in Mice |
|---|---|
| المؤلفون: | Molchanova, AY, Rjabceva, SN, Melik-Kasumov, TB, Pestov, NB, Angelova, PR, Shmanai, VV, Sharko, OL, Bekish, AV, James, G, Park, HG, Udalova, IA, Brenna, JT, Shchepinov, MS |
| المصدر: | Antioxidants , 11 (4) , Article 681. (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | lung, acute respiratory distress syndrome, arachidonic acid, D-PUFA, eicosanoids, isotope effect |
| الوصف: | Arachidonic acid (ARA) is a major component of lipid bilayers as well as the key substrate for the eicosanoid cascades. ARA is readily oxidized, and its non-enzymatic and enzymatic oxidation products induce inflammatory responses in nearly all tissues, including lung tissues. Deuteration at bis-allylic positions substantially decreases the overall rate of ARA oxidation when hydrogen abstraction is an initiating event. To compare the effects of dosing of arachidonic acid (H-ARA) and its bis-allylic hexadeuterated form (D-ARA) on lungs in conventionally healthy mice and in an acute lung injury model, mice were dosed with H-ARA or D-ARA for six weeks through dietary supplementation and then challenged with intranasal lipopolysaccharide (LPS) for subsequent analysis of bronchoalveolar lavage fluid and lung tissue. Dosing on D-ARA resulted in successful incorporation of D-ARA into various tissues. D-ARA significantly reduced LPS-induced adverse effects on alveolar septal thickness and the bronchoalveolar area. Oral deuterated ARA is taken up efficiently and protects against adverse LPS-induced pathology. This suggests novel therapeutic avenues for reducing lung damage during severe infections and other pathological conditions with inflammation in the pulmonary system and other inflammatory diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10147520/1/antioxidants-11-00681.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10147520Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10147520/1/antioxidants-11-00681.pdfTest https://discovery.ucl.ac.uk/id/eprint/10147520Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.C92B5A1E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |