دورية أكاديمية
Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation
| العنوان: | Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation |
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| المؤلفون: | Toshiro Seki, Rikio Suzuki, Shino Ohshima, Yoshiyuki Manabe, Shion Onoue, Yuki Hoshino, Atsushi Yasuda, Ryoji Ito, Hiroshi Kawada, Hitoshi Ishimoto, Takashi Shiina, Yoshie Kametani |
| المصدر: | Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101710- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Progesterone, Liposome, B cell lymphoma, Myeloma, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Progesterone suppresses several ancient pathways in a concentration-dependent manner. Based on these characteristics, progesterone is considered a candidate anticancer drug. However, the concentration of progesterone used for therapy should be higher than the physiological concentration, which makes it difficult to develop progesterone-based anticancer drugs. We previously developed liposome-encapsulated progesterone (Lipo-P4) with enhanced anticancer effects, which strongly suppressed triple-negative breast cancer cell proliferation in humanized mice. In this study, we aimed to clarify whether Lipo-P4 effectively suppresses the proliferation of B-lineage cancer cells. We selected six B-cell lymphoma and two myeloma cell lines, and analyzed their surface markers using flow cytometry. Next, we prepared liposome-encapsulated progesterone and examined its effect on cell proliferation in these B-lineage cancer cells, three ovarian clear cell carcinoma cell lines, two prostate carcinoma cell lines, and one triple-negative breast cancer adenocarcinoma cell line. Lipo-P4 suppressed the proliferation of all cancer cell lines. All B-lineage cell lines, except for the HT line, were more susceptible than the other cell types, regardless of the expression of differentiation markers. Empty liposomes did not suppress cell proliferation. These results suggest that progesterone encapsulated in liposomes efficiently inhibits the proliferation of B-lineage cells and may become an anticancer drug candidate for B-lineage cancers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-5808 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405580824000748Test; https://doaj.org/toc/2405-5808Test |
| DOI: | 10.1016/j.bbrep.2024.101710 |
| الوصول الحر: | https://doaj.org/article/566f11c0dfc24920a789291ca8bcf57dTest |
| رقم الانضمام: | edsdoj.566f11c0dfc24920a789291ca8bcf57d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24055808 |
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| DOI: | 10.1016/j.bbrep.2024.101710 |