يعرض 1 - 10 نتائج من 12 نتيجة بحث عن '"Shikang Liang"', وقت الاستعلام: 1.05s تنقيح النتائج
  1. 1
    Human DNA-dependent protein kinase activation mechanism

    المؤلفون: Shikang Liang, Tom Blundell

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom L [0000-0002-2708-8992], Apollo - University of Cambridge Repository, Blundell, Tom L. [0000-0002-2708-8992]

    مصطلحات موضوعية: DNA-Binding Proteins, DNA Repair, Structural Biology, Humans, Nuclear Proteins, Antigens, Nuclear, DNA-Activated Protein Kinase, DNA, Protein Serine-Threonine Kinases, Phosphorylation, Ligands, Molecular Biology, Protein Kinases

    وصف الملف: application/pdf; application/zip; text/xml

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1820efe6dcd9293a1c78701ff1d9ab95Test
    https://www.repository.cam.ac.uk/handle/1810/345133Test


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  2. 2
    Human DNA-dependent protein kinase activation mechanism

    المؤلفون: Shikang, Liang, Tom L, Blundell

    المصدر: Nature structuralmolecular biology.

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::90471d16f4d1297be1df0fe40495bd47Test
    https://pubmed.ncbi.nlm.nih.gov/36604499Test


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  3. 3
    Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

    المؤلفون: Shikang Liang, Sherine E. Thomas, Amanda K. Chaplin, Steven W. Hardwick, Dimitri Y. Chirgadze, Tom L. Blundell

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Hardwick, Steven W [0000-0001-9246-1864], Chirgadze, Dimitri Y [0000-0001-9942-0993], Blundell, Tom L [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    المصدر: Nature

    مصطلحات موضوعية: Multidisciplinary, DNA End-Joining Repair, DNA Repair, Small molecules, Cryoelectron Microscopy, Drug development, Kinases, DNA, DNA-Activated Protein Kinase, Article, Pyridazines, enzymes and coenzymes (carbohydrates), Adenosine Triphosphate, Catalytic Domain, Quinazolines, Humans, biological phenomena, cell phenomena, and immunity, Holoenzymes, Ku Autoantigen, HeLa Cells

    وصف الملف: application/pdf; application/zip; text/xml

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a9bdc5d634211cba0305d19a9b7de2Test
    https://www.repository.cam.ac.uk/handle/1810/333353Test


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  4. 4
    Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

    المؤلفون: Shikang Liang, Tom L. Blundell, Amanda K. Chaplin, Aleš Hnízda, Antonia Kefala Stavridi, Robert Appleby

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    المصدر: Progress in Biophysics and Molecular Biology

    مصطلحات موضوعية: Materials science, DNA End-Joining Repair, Spatial organisation, DNA Repair, Cryo-electron microscopy, DNA repair, Double-strand breaks, 030303 biophysics, Biophysics, KBM, Ku-binding motif, Computational biology, Article, 03 medical and health sciences, chemistry.chemical_compound, DNA-PK, DNA-dependent protein kinase, PAXX, Paralog of XRCC4 and XLF, XLF, XRCC4-Like Factor, Stages, Strings, Humans, DSB, double-strand break, DNA Breaks, Double-Stranded, Orchestration (computing), vWA, von Willebrand factor type A, cryo-EM, cryo-electron microscopy, PTIP, Pax transcription-activation-domain interacting protein, Molecular Biology, NHEJ, Cryo-EM, IR, ionising radiation, Scaffolds, 0303 health sciences, 53BP1, p53-binding protein 1, Cryoelectron Microscopy, X-ray diffraction, Non-homologous end joining, enzymes and coenzymes (carbohydrates), chemistry, DNA-PKcs, DNA-PK catalytic subunit, NHEJ, non-homologous end joining, X-ray crystallography, PNKP, polynucleotide kinase, APLF, aprataxin and PNKP-like factor, BRCT, BRCA1 C-Terminus domain, lncRNA, long noncoding RNA, HR, homologous recombination, DNA, CTR, C-terminal region

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca43e6e448ffae277c09ed2c9f19bd34Test
    https://www.repository.cam.ac.uk/handle/1810/316479Test


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  5. 5
    Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

    المؤلفون: Antonia Kefala Stavridi, Virginie Ropars, Shikang Liang, Amanda K. Chaplin, Jean-Baptiste Charbonnier, Dimitri Y. Chirgadze, Steven W. Hardwick, Noah J Goff, Tom L. Blundell, Taiana Maia de Oliveira, Katheryn Meek, Christopher J. Buehl

    المساهمون: Hardwick, Steven [0000-0001-9246-1864], Liang, Shikang [0000-0002-6930-7882], Chirgadze, Dima [0000-0001-9942-0993], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    مصطلحات موضوعية: DNA End-Joining Repair, DNA Repair, DNA repair, DNA damage, long-range synaptic complexes, Apoptosis, DNA-Activated Protein Kinase, Biology, non-homologous end joining, DNA-PK, chemistry.chemical_compound, DNA Ligase ATP, Humans, DNA Breaks, Double-Stranded, Phosphorylation, Molecular Biology, Ku Autoantigen, NHEJ, chemistry.chemical_classification, DNA ligase, Ku70, fungi, Cryoelectron Microscopy, Cell Biology, DNA repair protein XRCC4, Cell biology, Non-homologous end joining, DNA-Binding Proteins, enzymes and coenzymes (carbohydrates), DNA Repair Enzymes, chemistry, Multiprotein Complexes, cryo-EM, DNA, DNA Damage

    وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff291ec26fc79784cdf65b31e9d37f60Test


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  6. 6
    Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

    المؤلفون: Shikang Liang, Tom L. Blundell, Robert Appleby, Antonia Kefala Stavridi, Amanda K. Chaplin

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    المصدر: Essays in Biochemistry

    مصطلحات موضوعية: DNA End-Joining Repair, Computer science, DNA repair, Druggability, Cancer therapy, Biophysics, Cell Death & Injury, Computational biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, therapeutics, structural biology, Humans, DNA Breaks, Double-Stranded, multicomponent systems, Protein Interaction Maps, Binding site, Molecular Biology, Review Articles, 030304 developmental biology, Cancer, 0303 health sciences, DNA-repair, Pharmacology & Toxicology, Double Strand Break Repair, Non-homologous end joining, enzymes and coenzymes (carbohydrates), Structural biology, chemistry, 030220 oncology & carcinogenesis, embryonic structures, DNA

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2742056c52362d3481a470e01d449884Test


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  7. 7
    Dimers of DNA-PK create a stage for DNA double-strand break repair

    المؤلفون: Taiana Maia de Oliveira, Lee R Cooper, Antonia Kefala Stavridi, Amanda K. Chaplin, Tom L. Blundell, Shikang Liang, Aleš Hnízda, Dimitri Y. Chirgadze, Steven W. Hardwick

    المساهمون: Blundell, Tom L [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    مصطلحات موضوعية: DNA End-Joining Repair, Ku Autoantigen, Molecular Conformation, DNA-Activated Protein Kinase, Crystallography, X-Ray, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dna genetics, Structural Biology, Humans, DNA Breaks, Double-Stranded, Amino Acid Sequence, Molecular Biology, Peptide sequence, 030304 developmental biology, 0303 health sciences, Cryoelectron Microscopy, DNA, Molecular biology, Double Strand Break Repair, chemistry, Dna breaks, Double stranded, Dimerization, 030217 neurology & neurosurgery

    وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f304c752084a53735a663b170fd4efTest
    https://www.repository.cam.ac.uk/handle/1810/309624Test


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  8. 8
    Mechanism of efficient double-strand break repair by a long non-coding RNA

    المؤلفون: Shujuan Fang, Ruiqiong Ye, Aleš Hnízda, Roopa Thapar, Isaac Forrester, Chunru Lin, Linda Lee, Susan P. Lees-Miller, Heather Villarreal, Su S. Maw, Terence R. Strick, Miaw Sheue Tsai, Anthony J. Davis, Michal Hammel, Cheng-Cao Sun, Jing L. Wang, John A. Tainer, Shikang Liang, Tom L. Blundell, Ke Liang

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    المصدر: Nucleic acids research, vol 49, iss 2
    Nucleic acids research, vol 48, iss 19
    Nucleic Acids Research

    مصطلحات موضوعية: Ku80, DNA End-Joining Repair, DNA repair, AcademicSubjects/SCI00010, Biology, Genome Integrity, Repair and Replication, chemistry.chemical_compound, 03 medical and health sciences, Double-Stranded, Information and Computing Sciences, Genetics, Humans, DNA Breaks, Double-Stranded, Ku Autoantigen, 030304 developmental biology, Cancer, Ku70, 0303 health sciences, 030302 biochemistry & molecular biology, DNA Breaks, RNA, Biological Sciences, Double Strand Break Repair, Long non-coding RNA, Cell biology, DNA-Binding Proteins, chemistry, Hela Cells, RNA, Long Noncoding, Long Noncoding, Protein Multimerization, Corrigendum, DNA, Environmental Sciences, HeLa Cells, Protein Binding, Developmental Biology

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b781589855c1cecba86e0d9403f5e987Test
    https://escholarship.org/uc/item/2vn6m49tTest


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  9. 9
    Dimers of DNA-PK create a stage for DNA double-strand break repair

    المؤلفون: Amanda K, Chaplin, Steven W, Hardwick, Shikang, Liang, Antonia, Kefala Stavridi, Ales, Hnizda, Lee R, Cooper, Taiana Maia, De Oliveira, Dimitri Y, Chirgadze, Tom L, Blundell

    المصدر: Nature structuralmolecular biology. 28(1)

    مصطلحات موضوعية: DNA End-Joining Repair, Cryoelectron Microscopy, Molecular Conformation, Humans, DNA Breaks, Double-Stranded, Amino Acid Sequence, DNA, DNA-Activated Protein Kinase, Crystallography, X-Ray, Dimerization, Ku Autoantigen

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::9dcae09b6964d175267406ba6837a8bfTest
    https://pubmed.ncbi.nlm.nih.gov/33077952Test


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  10. 10
    Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways

    المؤلفون: Qian Wu, Takashi Ochi, Tom L. Blundell, Dimitri Y. Chirgadze, Juha T. Huiskonen, Shikang Liang

    المساهمون: Liang, Shikang [0000-0002-6930-7882], Chirgadze, Dima [0000-0001-9942-0993], Blundell, Tom [0000-0002-2708-8992], Apollo - University of Cambridge Repository

    مصطلحات موضوعية: DNA End-Joining Repair, DNA damage, DNA repair, Biophysics, DNA-Activated Protein Kinase, Crystallography, X-Ray, DNA-PK, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein Domains, Animals, Humans, Molecular Biology, DNA-PKcs, NHEJ, 030304 developmental biology, Cryo-EM, X-ray crystallography, 0303 health sciences, Ku70, Cryoelectron Microscopy, DNA replication, Synapsis, Ku70/80, chemistry, DSBs, 030217 neurology & neurosurgery, DNA

    وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96892b8c0ae658ab4149f3b9c93e4bdTest


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