التفاصيل البيبلوغرافية
| العنوان: |
Copper Sulfide Nanoassemblies for Catalytic and Photoresponsive Eradication of Bacteria from Infected Wounds |
| المؤلفون: |
Amit Nain (8739654), Shih-Chun Wei (2080663), Yu-Feng Lin (141727), Yu-Ting Tseng (1564129), Ranju Prasad Mandal (10144520), Yu-Fen Huang (1699075), Chih-Ching Huang (1609990), Fan-Gang Tseng (1660861), Huan-Tsung Chang (1437532) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Microbiology, Pharmacology, Cancer, Infectious Diseases, Virology, Space Science, Chemical Sciences not elsewhere classified, BSA gel-like structures, hydrogen peroxide, hydroxyl radicals, CPO, methicillin-resistant Staphylococcu., sulfur source, antimicrobial response, surface vacancies, 1 min, copper peroxide, Infected Wounds Bovine serum albumin, Photoresponsive Eradication, photothermal properties, catalyze singlet oxygen, NIR laser irradiation, NIR illumination, photothermal inactivation, photothermal treatment, infection site, H 2 O 2 |
| الوصف: |
Bovine serum albumin (BSA)-encapsulated copper sulfide nanocrystals (CuS NCs) were prepared by heating an alkaline solution containing copper ions and BSA without an additional sulfur source. At a high BSA concentration (0.8 mM), nanoassembly of the as-formed CuS NCs occurs to form BSA–CuS NCs as a result of the formation of BSA gel-like structures. In addition to their intrinsic photothermal properties, the BSA–CuS NCs possess rich surface vacancies and thus exhibit enzyme-like and photodynamic activities. Spontaneous generation of hydrogen peroxide (H 2 O 2 ) led to the in situ formation of copper peroxide (CPO) nanodots on the BSA–CuS NCs to catalyze singlet oxygen radical generation. The antimicrobial response was enhanced by >60-fold upon NIR laser irradiation, which was ascribed to the combined effect of the photodynamic and photothermal inactivation of bacteria. Furthermore, BSA–CuS NCs were transdermally administered onto a methicillin-resistant Staphylococcus aureus-infected wound and eradicated >99% of bacteria in just 1 min under NIR illumination due to the additional peroxidase-like activity of BSA–CuS NCs, transforming H 2 O 2 at the infection site into hydroxyl radicals and thus increasing the synergistic effect from photodynamic and photothermal treatment. The BSA–CuS NCs exhibited insignificant in vitro cytotoxicity and hemolysis and thus can serve as highly biocompatible bactericides in preclinical applications to effectively eradicate bacteria. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Copper_Sulfide_Nanoassemblies_for_Catalytic_and_Photoresponsive_Eradication_of_Bacteria_from_Infected_Wounds/14035643Test |
| DOI: |
10.1021/acsami.0c18999.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsami.0c18999.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.D1C9C4BB |
| قاعدة البيانات: |
BASE |
