دورية أكاديمية
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
| العنوان: | Immobility-associated thromboprotection is conserved across mammalian species from bear to human |
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| المؤلفون: | Thienel, Manuela, Müller-Reif, Johannes B., Zhang, Zhe, Ehreiser, Vincent, Huth, Judith, Shchurovska, Khrystyna, Kilani, Badr, Schweizer, Lisa, Geyer, Philipp E., Zwiebel, Maximilian, Novotny, Julia, Lüsebrink, Enzo, Little, Gemma, Orban, Martin, Nicolai, Leo, El Nemr, Shaza, Titova, Anna, Spannagl, Michael, Kindberg, Jonas, Evans, Alina L., Mach, Orpheus, Vogel, Matthias, Tiedt, Steffen, Ormanns, Steffen, Kessler, Barbara, Dueck, Anne, Friebe, Andrea, Jørgensen, Peter Godsk, Majzoub-Altweck, Monir, Blutke, Andreas, Polzin, Amin, Stark, Konstantin, Kääb, Stefan, Maier, Doris, Gibbins, Jonathan M., Limper, Ulrich, Frobert, Ole, Mann, Matthias, Massberg, Steffen, Petzold, Tobias |
| المصدر: | Thienel , M , Müller-Reif , J B , Zhang , Z , Ehreiser , V , Huth , J , Shchurovska , K , Kilani , B , Schweizer , L , Geyer , P E , Zwiebel , M , Novotny , J , Lüsebrink , E , Little , G , Orban , M , Nicolai , L , El Nemr , S , Titova , A , Spannagl , M , Kindberg , J , Evans , A L , Mach , O , Vogel , M , Tiedt , S , Ormanns , S .... |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| الوصف: | Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry–based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/0e570ef2-33f6-4aed-a159-fc19393ce14bTest |
| DOI: | 10.1126/science.abo5044 |
| الإتاحة: | https://doi.org/10.1126/science.abo5044Test https://pure.au.dk/portal/en/publications/0e570ef2-33f6-4aed-a159-fc19393ce14bTest http://www.scopus.com/inward/record.url?scp=85152454110&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6A78B7DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/science.abo5044 |
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