المؤلفون: Christian Nilewski, Sharada Labadie, Binqing Wei, Sushant Malhotra, Steven Do, Lewis Gazzard, Li Liu, Cheng Shao, Jeremy Murray, Yevgeniy Izrayelit, Amy Gustafson, Nicholas F. Endres, Fang Ma, Xin Ye, Jun Zou, Marie Evangelista

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, targeting certain p, switch ii pocket, loop mutant proteins, identified decades ago, gdp state via, clinically validated strategy, selective reversible inhibitors, particular kras g12c, kras mutant proteins, d13 side chain, d13 residue relative, wt kras, kras g13d, kras <, selective inhibition, target selectively, subnanomolar binding, solvent exposure, salt bridge, recent progress, ongoing challenge, conformational flexibility

العلاقة: https://figshare.com/articles/journal_contribution/Structure-Based_Design_and_Evaluation_of_Reversible_KRAS_G13D_Inhibitors/24755604Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00478.s001Test
https://figshare.com/articles/journal_contribution/Structure-Based_Design_and_Evaluation_of_Reversible_KRAS_G13D_Inhibitors/24755604Test

المؤلفون: Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Fulvestrant, 010405 organic chemistry, Chemistry, Organic Chemistry, Azetidine, Uterus, Antagonist, Estrogen receptor, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Breast cancer, medicine.anatomical_structure, Drug Discovery, medicine, Cancer research, Estrogen receptor alpha, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42f6062f9f361a3f700a527fd2a8dcTest
https://doi.org/10.1021/acsmedchemlett.0c00224Test

المؤلفون: Yanzhou Liu, Sharada Labadie, Karine Thai, Jessica M. Grandner, Brendan T. Parr

المصدر: The Journal of organic chemistry. 86(20)

مصطلحات موضوعية: Enyne, Molecular Structure, Chemistry, Pyridones, Organic Chemistry, Iminium, Ring (chemistry), Combinatorial chemistry, Amides, Catalysis, chemistry.chemical_compound, Cyclization, Yield (chemistry), Amide, Amine gas treating

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d4fa6cf6faedbc8c5582c0a58e9570Test
https://pubmed.ncbi.nlm.nih.gov/34337936Test

المؤلفون: Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini

المصدر: Journal of medicinal chemistry. 64(16)

مصطلحات موضوعية: Phases of clinical research, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, Breast cancer, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Dosing, Molecular Structure, Chemistry, Antagonist, Estrogen Receptor alpha, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, Macaca fascicularis, Cell culture, Cancer research, MCF-7 Cells, Molecular Medicine, Female, Estrogen Receptor Antagonists, Carbolines

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710Test
https://pubmed.ncbi.nlm.nih.gov/34251202Test

المؤلفون: Keira Garland, Richard Pastor, Gauri Deshmukh, Min Xu, Emily J. Hanan, Paul Gibbons, Yi-Chen Chen, Susan L. Gloor, Sharookh B. Kapadia, Homer Pantua, Sharada Labadie, Rongbao Hua, Yiming Xu, Marie-Gabrielle Braun, Yuhong Fu, Craig Stivala, Xiongcai Liu, Georgette Castanedo, Jonathan Cheong, Daniels Blake, Hao Zheng, Daniel J. Burdick, Yun-Xing Cheng

المصدر: Bioorganicmedicinal chemistry letters. 30(20)

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Antibiotics, Pharmaceutical Science, Microbial Sensitivity Tests, Lipoprotein signal peptidase, 01 natural sciences, Biochemistry, Unmet needs, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Escherichia coli, Molecular Biology, Gram, Depsipeptide, Signal peptidase, Natural product, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, 0104 chemical sciences, Anti-Bacterial Agents, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182cd264e9ec08564bbb5c07f04cdf6dTest
https://pubmed.ncbi.nlm.nih.gov/32768648Test

المؤلفون: Mike Reichelt, Inna Zilberleyb, Hans E. Purkey, Hoangdung Ho, Benjamin D. Sellers, Maureen Beresini, Jian Payandeh, Vishal Verma, Natalie K. Garcia, Yvonne Franke, Yan Lu, Till Maurer, James R. Kiefer, Angela Oh, John G. Quinn, Aaron T. Wecksler, Yiming Xu, Mary Kate Alexander, Man-Wah Tan, Anh Miu, Stephanie Shriver, Christopher M. Koth, Jun Liang, Christine Tam, Mireille Nishiyama, Sharada Labadie, Michael F. T. Koehler, Kevin R Clark, Huiyong Hu, Jian Wang, Lan Wang, Cary D. Austin

المصدر: Nature. 557:196-201

مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, 0301 basic medicine, Protein family, 030106 microbiology, Allosteric regulation, ATP-binding cassette transporter, Crystallography, X-Ray, 03 medical and health sciences, Allosteric Regulation, Bacterial Proteins, Protein Domains, Escherichia coli, Inner membrane, ABC Transporter Inhibition, Lipid Transport, Binding Sites, Multidisciplinary, Dose-Response Relationship, Drug, Chemistry, Transporter, Hydrocarbons, Transmembrane protein, Anti-Bacterial Agents, 030104 developmental biology, Quinolines, Biophysics, ATP-Binding Cassette Transporters

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdded180233b15f2f4abb1c64264d81Test
https://doi.org/10.1038/s41586-018-0083-5Test

المؤلفون: Kuen Yeap, Birong Zhang, Jae H. Chang, Lori Friedman, Nick Ray, Jiangpeng Liao, Xiaojing Wang, Amy Sambrone, Jun Li, Yu Zhong, Ellen Ingalla, Jason R. Zbieg, Daniel F. Ortwine, Vidhi Mody, John S. Wai, Tao Wang, Maia Vinogradova, Sharada Labadie, Steven J. Hartman, Tracy Kleinheinz, Nev McLean, Tommy Lai, Simon Charles Goodacre, Deepak Sampath, Jun Liang, Fabien Roussel, James R. Kiefer, Ciara Metcalfe, Xiaoping Zheng, Yingqing Ran, Michelle Nannini, Robert A. Blake

المصدر: Bioorganic & Medicinal Chemistry Letters. 50:128335

مصطلحات موضوعية: Drug, Protein Conformation, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Pharmacology, Biochemistry, Mice, Route of administration, Breast cancer, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Fulvestrant, Chemistry, Organic Chemistry, Antagonist, medicine.disease, Xenograft Model Antitumor Assays, Bioavailability, Receptors, Estrogen, MCF-7 Cells, Molecular Medicine, Female, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4ca868520e02822732a1114f5f125cTest
https://doi.org/10.1016/j.bmcl.2021.128335Test

المؤلفون: Yichin Liu, Peter S. Dragovich, Daniel F. Ortwine, Birong Zhang, Richard D. Cummings, Jun Liang, Yingqing Ran, Marie Classon, Sharada Labadie, Tommy Lai, Weifeng Mao, Victor S. Gehling, Bianca M. Liederer, Erica Van der Porten, Jean-Christophe Harmange, Till Mauer, Le An, Xiaoping Zheng, Jiangpeng Liao, James R. Kiefer, Maia Vinogradova, Snahel Patel, Patrick Trojer, Gauri Deshmukh, Amy Gustafson, Lesley J. Murray

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2974-2981

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Cmax, Administration, Oral, Biological Availability, Pharmaceutical Science, Plasma protein binding, Pharmacology, Pyrazole, 01 natural sciences, Biochemistry, Pyrrolidine, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potency, Enzyme Inhibitors, Molecular Biology, Cell potency, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, High-Throughput Screening Assays, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Lipophilicity, Microsomes, Liver, Pyrazoles, Molecular Medicine, Retinoblastoma-Binding Protein 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55347996293ce1a7c7b826ca989d0efTest
https://doi.org/10.1016/j.bmcl.2017.05.016Test

المؤلفون: Charles Z. Ding, Laurent Salphati, Hans E. Purkey, HongXiu Ge, Qin Yue, Antonio G. DiPasquale, Charles Eigenbrot, Qunh Ho, Kwong Wah Lai, Thomas O'Brien, Sharada Labadie, Zhongguo Chen, David A. Peterson, Shiva Malek, Laura Corson, Wenfeng Liu, Mark Ultsch, Jinhua Chen, Anna Hitz, Yajing Liu, Kirk Robarge, Jodie Pang, Chiho Li, Peter S. Dragovich, Binqing Wei, Shuguang Ma, Huihui Zhang, Steve Sideris, Zhenting Gao, Marie Evangelista, Ivana Yen, Aihe Zhou, Benjamin Fauber

المصدر: ACS Medicinal Chemistry Letters. 7:896-901

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Organic Chemistry, Cell, Biology, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Enzyme, chemistry, Cell culture, 030220 oncology & carcinogenesis, Lactate dehydrogenase, Drug Discovery, medicine, Glycolysis, IC50

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0532bd0e9287d033f18781fd7cf755Test
https://doi.org/10.1021/acsmedchemlett.6b00190Test

المؤلفون: Yichin Liu, Xiaoping Zheng, Lesley J. Murray, Marie Classon, Birong Zhang, Erica Van der Porten, Amy Gustafson, Jiangpeng Liao, Maia Vinogradova, Jean-Christophe Harmange, Weifeng Mao, Bianca M. Liederer, Tommy Lai, Sharada Labadie, Patrick Trojer, Richard D. Cummings, Victor S. Gehling, Gauri Deshmukh, James R. Kiefer, Peter S. Dragovich, Daniel F. Ortwine, Jun Liang

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4036-4041

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Cell, Cmax, Administration, Oral, Pharmaceutical Science, Pyrimidinones, Molecular Dynamics Simulation, Pharmacology, Crystallography, X-Ray, Biochemistry, Histones, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Binding site, Molecular Biology, EC50, Binding Sites, Chemistry, Organic Chemistry, Rats, Bioavailability, 030104 developmental biology, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Microsomes, Liver, Pyrazoles, Molecular Medicine, Female, Retinoblastoma-Binding Protein 2, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca2fc00b367f08650c72962e0d79153Test
https://doi.org/10.1016/j.bmcl.2016.06.078Test