التفاصيل البيبلوغرافية
| العنوان: |
Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe 3 O 4 @PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound |
| المؤلفون: |
Chieh-Wei Chung (11937761), Bo-Wen Liao (11937764), Shu-Wei Huang (170521), Show-Jen Chiou (2315878), Cheng-Han Chang (4776042), Sheng-Ju Lin (8890493), Bo-Hao Chen (3371339), Wei-Ling Liu (378597), Shang-Hsiu Hu (2294941), Yu-Chun Chuang (1620862), Chia-Her Lin (840308), I-Jui Hsu (1733785), Chao-Min Cheng (267550), Chieh-Cheng Huang (2607580), Tsai-Te Lu (1975147) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Biotechnology, Cancer, Computational Biology, Space Science, Chemical Sciences not elsewhere classified, triggered bactericidal effect, subsequent collagen formation, novel therapeutic approach, location -/ concentration, dependent physiological function, cardio ) vascular, >- thioglycerol )(, >- glycolic acid, infected cutaneous wound, alternating magnetic field, positive staphylococcus aureus, obtained conjugates within, negative escherichia coli, 4 , 3 , 2 , magnetic responsive release, magnetic responsive, wound healing, magnetic hyperthermia |
| الوصف: |
Nitric oxide (NO) is an essential endogenous signaling molecule regulating multifaceted physiological functions in the (cardio)vascular, neuronal, and immune systems. Due to the short half-life and location-/concentration-dependent physiological function of NO, translational application of NO as a novel therapeutic approach, however, awaits a strategy for spatiotemporal control on the delivery of NO. Inspired by the magnetic hyperthermia and magneto-triggered drug release featured by Fe 3 O 4 conjugates, in this study, we aim to develop a magnetic responsive NO-release material (MagNORM) featuring dual NO-release phases, namely, burst and steady release, for the selective activation of NO-related physiology and treatment of bacteria-infected cutaneous wound. After conjugation of NO-delivery [Fe(μ- S -thioglycerol)(NO) 2 ] 2 with a metal–organic framework (MOF)-derived porous Fe 3 O 4 @C, encapsulation of obtained conjugates within the thermo-responsive poly(lactic- co -glycolic acid) (PLGA) microsphere completes the assembly of MagNORM. Through continuous/pulsatile/no application of the alternating magnetic field (AMF) to MagNORM, moreover, burst/intermittent/slow release of NO from MagNORM demonstrates the AMF as an ON/OFF switch for temporal control on the delivery of NO. Under continuous application of the AMF, in particular, burst release of NO from MagNORM triggers an effective anti-bacterial activity against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). In addition to the magneto-triggered bactericidal effect of MagNORM against E. coli-infected cutaneous wound in mice, of importance, steady release of NO from MagNORM without the AMF promotes the subsequent collagen formation and wound healing in mice. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Magnetic_Responsive_Release_of_Nitric_Oxide_from_an_MOF-Derived_Fe_sub_3_sub_O_sub_4_sub_PLGA_Microsphere_for_the_Treatment_of_Bacteria-Infected_Cutaneous_Wound/19071647Test |
| DOI: |
10.1021/acsami.1c20802.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsami.1c20802.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.CD9150F5 |
| قاعدة البيانات: |
BASE |
