SARS‐CoV‐2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions
| العنوان: | SARS‐CoV‐2 outbreak in Iran: The dynamics of the epidemic and evidence on two independent introductions |
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| المؤلفون: | Gholam Abbas Kaydani, Seyedeh Elham Mortazavi, Seyed Amir Momeni, Talat Mokhtari-Azad, Fatemeh Aghakhani Moghadam, Hanieh Behravan, Mohammad Khazeni, Azarakhsh Azaran, Zakiye Mokhames, Farhad Jeddi, Ebrahim Kord, Seyed Mohammad Hashemi-Shahri, Azam Ghaziasadi, Alijan Tabarraei, Fatemeh Ghodratpour, Masood Ziaee, Ali Jafarpour, Jila Yavarian, Abdolvahab Moradi, Azar Hadadi, Zohreh Fattahi, Hossein Najmabadi, Shokouh Ghafari, Issa Jahanzad, Reza Malekzadeh, Marzieh Mohseni, Farid Yousefi, Shahram Habibzadeh, Seyed Mohammad Jazayeri, Khadijeh Jalalvand, Saber Soltani, Kimia Kahrizi, Alireza Soleimani, Sadegh Ali Azimi, Reza Najafipour, Alireza Abdollahi, Fatemeh Keshavarzi |
| المصدر: | Transboundary and Emerging Diseases |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Most recent common ancestor, 040301 veterinary sciences, viruses, Lineage (evolution), Zoology, Genome, Viral, Iran, Biology, SARS‐CoV‐2, Virus, Disease Outbreaks, law.invention, 0403 veterinary science, phylogenetic study, 03 medical and health sciences, COVID‐19, law, Pandemic, Animals, Phylogeny, 030304 developmental biology, whole genome sequencing, 0303 health sciences, Genetic diversity, General Veterinary, General Immunology and Microbiology, SARS-CoV-2, COVID-19, Outbreak, Original Articles, 04 agricultural and veterinary sciences, General Medicine, Transmission (mechanics), Mutation (genetic algorithm), Original Article |
| الوصف: | The SARS‐CoV‐2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence. While Iran was among the first countries confronted with rapid spread of virus in February 2020, no real‐time SARS‐CoV‐2 whole‐genome tracking in early phase of outbreak was performed in the country. To address this issue, we provided 50 whole‐genome sequences of viral isolates ascertained from different geographical locations in Iran during March–July 2020. The corresponding analysis on origins, transmission dynamics and genetic diversity of SARS‐CoV‐2 virus, represented at least two introductions of the virus into the country, constructing two major clusters defined as B.4 and B.1*. The first entry of the virus might have occurred around very late 2019/early 2020, as suggested by the time to the most recent common ancestor, followed by a rapid community transmission that led to dominancy of B.4 lineage in early epidemic till the end of June. Gradually, reduction in dominancy of B.4 occurred possibly as a result of other entries of the virus, followed by surge of B.1* lineages, as of mid‐May. Remarkably, variation tracking of the virus indicated the increase in frequency of D614G mutation, along with B.1* lineages, which showed continuity till October 2020. The increase in frequency of D614G mutation and B.1* lineages from mid‐May onwards predicts a rapid viral transmission that may push the country into a critical health situation followed by a considerable change in composition of viral lineages circulating in the country. |
| تدمد: | 1865-1682 1865-1674 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c82245f4fea38cae05cc1b94f251910Test https://doi.org/10.1111/tbed.14104Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c82245f4fea38cae05cc1b94f251910 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18651682 18651674 |
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