التفاصيل البيبلوغرافية
| العنوان: |
Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults:results from a meta-analysis and exploratory meta-regression analysis |
| المؤلفون: |
Veronese, N. (Nicola), Cereda, E. (Emanuele), Stubbs, B. (Brendon), Solmi, M. (Marco), Luchini, C. (Claudio), Manzato, E. (Enzo), Sergi, G. (Giuseppe), Manu, P. (Peter), Harris, T. (Tamara), Fontana, L. (Luigi), Strandberg, T. (Timo), Amieva, H. (Helene), Dumurgier, J. (Julien), Elbaz, A. (Alexis), Tzourio, C. (Christophe), Eicholzer, M. (Monika), Rohrmann, S. (Sabine), Moretti, C. (Claudio), D’Ascenzo, F. (Fabrizio), Quadri, G. (Giorgio), Polidoro, A. (Alessandro), Lourenço, R. A. (Roberto Alves), Moreira, V. G. (Virgilio Garcia), Sanchis, J. (Juan), Scotti, V. (Valeria), Maggi, S. (Stefania), Correll, C. U. (Christoph U.) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2017 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
Frailty, cardiovascular disease, meta-analysis |
| الوصف: |
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18–2.45]; I² = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07–1.36]; I² = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2019091928791Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2017 Elsevier B.V. Allr ights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0Test/. ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.7B388431 |
| قاعدة البيانات: |
BASE |
