المؤلفون: Makhaeva, G. F., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Lushchekina, S. V., Astakhova, T. Y., Timokhina, E. N., Serebryakova, O. G., Shchepochkin, A. V., Averkov, M. A., Utepova, I. A., Demina, N. S., Radchenko, E. V., Palyulin, V. A., Fisenko, V. P., Bachurin, S. O., Chupakhin, O. N., Charushin, V. N., Richardson, R. J.

المصدر: Frontiers in Pharmacology

مصطلحات موضوعية: 9-PHOSPHORYL-9,10-DIHYDROACRIDINES, 9-PHOSPHORYLACRIDINES, ACETYLCHOLINESTERASE, ALZHEIMER’S DISEASE, BUTYRYLCHOLINESTERASE, 9 PHOSPHORYL 9,10 DIHYDROACRIDINES, 9 PHOSPHORYLACRIDINES, ACRIDINE DERIVATIVE, AMYLOID BETA PROTEIN, ANTIOXIDANT, CARBOXYLESTERASE, CHOLINESTERASE, CHOLINESTERASE INHIBITOR, UNCLASSIFIED DRUG, ABTS RADICAL SCAVENGING ASSAY, ALZHEIMER DISEASE, ANTIOXIDANT ACTIVITY, ARTICLE, ASSAY, BLOOD BRAIN BARRIER, CARDIOTOXICITY, DRUG PENETRATION, ENZYME ACTIVITY, ENZYME INHIBITION, FERRIC REDUCING ANTIOXIDANT POWER, FERRIC REDUCING ANTIOXIDANT POWER ASSAY, FLUORESCENCE INTENSITY, HIGH TEMPERATURE PROCEDURES, HUMAN, IN VITRO STUDY

وصف الملف: application/pdf

العلاقة: Makhaeva, G, Kovaleva, N, Rudakova, E, Boltneva, N, Lushchekina, S, Astakhova, T, Timokhina, E, Serebryakova, O, Shchepochkin, A, Averkov, M, Utepova, I, Demina, N, Radchenko, E, Palyulin, V, Fisenko, VP, Bachurin, S, Chupakhin, O, Charushin, V & Richardson, R 2023, 'Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease', Frontiers in Pharmacology, Том. 14, 1219980. https://doi.org/10.3389/fphar.2023.1219980Test; Makhaeva, G., Kovaleva, N., Rudakova, E., Boltneva, N., Lushchekina, S., Astakhova, T., Timokhina, E., Serebryakova, O., Shchepochkin, A., Averkov, M., Utepova, I., Demina, N., Radchenko, E., Palyulin, V., Fisenko, V. P., Bachurin, S., Chupakhin, O., Charushin, V., & Richardson, R. (2023). Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease. Frontiers in Pharmacology, 14, [1219980]. https://doi.org/10.3389/fphar.2023.1219980Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169578072&doi=10.3389%2ffphar.2023.1219980&partnerID=40&md5=e5a9703fe921a2849ee1d5766d8a9381Test; https://www.frontiersin.org/articles/10.3389/fphar.2023.1219980/pdfTest; http://elar.urfu.ru/handle/10995/130756Test; 85169578072; 001057900600001

الإتاحة: https://doi.org/10.3389/fphar.2023.1219980Test
http://elar.urfu.ru/handle/10995/130756Test

المؤلفون: Burgart, Y. V., Elkina, N. A., Shchegolkov, E. V., Krasnykh, O. P., Makhaeva, G. F., Triandafilova, G. A., Solodnikov, S. Y., Boltneva, N. P., Rudakova, E. V., Kovaleva, N. V., Serebryakova, O. G., Ulitko, M. V., Borisevich, S. S., Gerasimova, N. A., Evstigneeva, N. P., Kozlov, S. A., Korolkova, Y. V., Minin, A. S., Belousova, A. V., Mozhaitsev, E. S., Klabukov, A. M., Saloutin, V. I.

المصدر: Molecules

مصطلحات موضوعية: 4-ARYLHYDRAZINYLIDENEPYRAZOL-3-ONES, ADME PROFILE, ANTIMICROBIAL ACTIVITY, ANTINOCICEPTIVE EFFECT, ANTIOXIDANT ACTIVITY, CARBOXYLESTERASE INHIBITOR, CYTOTOXICITY, TRPV1 RECEPTOR INHIBITOR, ANTIOXIDANT, DICLOFENAC, DRUG, CHEMISTRY, HUMAN, MOLECULAR DOCKING, ANTIOXIDANTS, HUMANS, MOLECULAR DOCKING SIMULATION, PHARMACEUTICAL PREPARATIONS

وصف الملف: application/pdf

العلاقة: Burgart, YV, Elkina, NA, Shchegolkov, EV, Krasnykh, OP, Makhaeva, GF, Triandafilova, GA, Solodnikov, SY, Boltneva, NP, Rudakova, EV, Kovaleva, NV, Serebryakova, OG, Ulitko, MV, Borisevich, SS, Gerasimova, NA, Evstigneeva, NP, Kozlov, SA, Korolkova, YV, Minin, AS, Belousova, AV, Mozhaitsev, ES, Klabukov, AM & Saloutin, VI 2023, 'Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals', Molecules, Том. 28, № 1, 59. https://doi.org/10.3390/molecules28010059Test; Burgart, Y. V., Elkina, N. A., Shchegolkov, E. V., Krasnykh, O. P., Makhaeva, G. F., Triandafilova, G. A., Solodnikov, S. Y., Boltneva, N. P., Rudakova, E. V., Kovaleva, N. V., Serebryakova, O. G., Ulitko, M. V., Borisevich, S. S., Gerasimova, N. A., Evstigneeva, N. P., Kozlov, S. A., Korolkova, Y. V., Minin, A. S., Belousova, A. V., . Saloutin, V. I. (2023). Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals. Molecules, 28(1), [59]. https://doi.org/10.3390/molecules28010059Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145721993&doi=10.3390%2fmolecules28010059&partnerID=40&md5=40abed089c93b2d2117287a0bae505d0Test; https://www.mdpi.com/1420-3049/28/1/59/pdf?version=1672046166Test; http://elar.urfu.ru/handle/10995/130503Test; 85145721993; 000910041900001

الإتاحة: https://doi.org/10.3390/molecules28010059Test
http://elar.urfu.ru/handle/10995/130503Test
https://www.mdpi.com/1420-3049/28/1/59/pdf?version=1672046166Test

المؤلفون: Makhaeva, G. F., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Grishchenko, M. V., Lushchekina, S. V., Astakhova, T. Y., Serebryakova, O. G., Timokhina, E. N., Zhilina, E. F., Shchegolkov, E. V., Ulitko, M. V., Radchenko, E. V., Palyulin, V. A., Burgart, Y. V., Saloutin, V. I., Bachurin, S. O., Richardson, R. J.

المصدر: International Journal of Molecular Sciences

مصطلحات موضوعية: ACETYLCHOLINESTERASE, ADMET PREDICTION, ALZHEIMER’S DISEASE, ANTIOXIDANT ACTIVITY, AΒ42 SELF-AGGREGATION, BUTYRYLCHOLINESTERASE, METAL CHELATION, PROPIDIUM DISPLACEMENT, SALICYLIC ACID DERIVATIVES, TACRINE CONJUGATES, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 2 METHYL N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYLIMINOMETHYL]PHENOL, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYLIMINOMETHYL]PHENOL, 2 [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYLIMINOMETHYL]PHENOL, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 4,5 DIFLUORO 2 HYDROXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)BUTYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)HEXYL]BENZAMIDE, 4,5 DIFLUORO 2 METHOXY N [4 (1,2,3,4 TETRAHYDROACRIDIN 9 YLAMINO)OCTYL]BENZAMIDE, AMYLOID BETA PROTEIN[1-42], ANTIOXIDANT, ASCORBIC ACID, CHELATING AGENT, CHOLINESTERASE, CHOLINESTERASE INHIBITOR, COPPER, DONEPEZIL

وصف الملف: application/pdf

العلاقة: Makhaeva, GF, Kovaleva, NV, Rudakova, EV, Boltneva, NP, Grishchenko, MV, Lushchekina, SV, Astakhova, TY, Serebryakova, OG, Timokhina, EN, Zhilina, EF, Shchegolkov, EV, Ulitko, MV, Radchenko, EV, Palyulin, VA, Burgart, YV, Saloutin, VI, Bachurin, SO & Richardson, RJ 2023, 'Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease', International Journal of Molecular Sciences, Том. 24, № 3, 2285. https://doi.org/10.3390/ijms24032285Test; Makhaeva, G. F., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Grishchenko, M. V., Lushchekina, S. V., Astakhova, T. Y., Serebryakova, O. G., Timokhina, E. N., Zhilina, E. F., Shchegolkov, E. V., Ulitko, M. V., Radchenko, E. V., Palyulin, V. A., Burgart, Y. V., Saloutin, V. I., Bachurin, S. O., & Richardson, R. J. (2023). Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease. International Journal of Molecular Sciences, 24(3), [2285]. https://doi.org/10.3390/ijms24032285Test; Final; All Open Access, Gold, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148003235&doi=10.3390%2fijms24032285&partnerID=40&md5=fe6438dda642e3160d82a1abfe2c8c8bTest; https://www.mdpi.com/1422-0067/24/3/2285/pdf?version=1675907905Test; http://elar.urfu.ru/handle/10995/130201Test; 85148003235; 000935706300001

الإتاحة: https://doi.org/10.3390/ijms24032285Test
http://elar.urfu.ru/handle/10995/130201Test
https://www.mdpi.com/1422-0067/24/3/2285/pdf?version=1675907905Test

المؤلفون: Burgart, Y. V., Makhaeva, G. F., Krasnykh, O. P., Borisevich, S. S., Agafonova, N. A., Kovaleva, N. V., Boltneva, N. P., Rudakova, E. V., Shchegolkov, E. V., Triandafilova, G. A., Gazizov, D. A., Serebryakova, O. G., Ulitko, M. V., Khursan, S. L., Saloutin, V. I., Richardson, R. J.

المصدر: Molecules

مصطلحات موضوعية: 4-AMINOPYRAZOL-5-OLS, 4-HYDROXYIMINOPYRAZOL-5-ONES, ANTIOXIDANTS, ANTIRADICAL AND FERRIC REDUCING ACTIVITY, EDARAVONE, QUANTUM-CHEMICAL CALCULATIONS, CHOLINESTERASE INHIBITORS, HUMANS, 2,2'-AZINO-DI-(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID, ANTIOXIDANT, CHOLINESTERASE INHIBITOR, NORPHENAZONE, CHEMISTRY, HUMAN

وصف الملف: application/pdf

العلاقة: Burgart, YV, Makhaeva, GF, Krasnykh, OP, Borisevich, SS, Agafonova, NA, Kovaleva, NV, Boltneva, NP, Rudakova, EV, Shchegolkov, EV, Triandafilova, GA, Gazizov, DA, Serebryakova, OG, Ulitko, MV, Khursan, SL, Saloutin, VI & Richardson, RJ 2022, 'Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity', Molecules, Том. 27, № 22, 7722. https://doi.org/10.3390/molecules27227722Test; Burgart, Y. V., Makhaeva, G. F., Krasnykh, O. P., Borisevich, S. S., Agafonova, N. A., Kovaleva, N. V., Boltneva, N. P., Rudakova, E. V., Shchegolkov, E. V., Triandafilova, G. A., Gazizov, D. A., Serebryakova, O. G., Ulitko, M. V., Khursan, S. L., Saloutin, V. I., & Richardson, R. J. (2022). Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity. Molecules, 27(22), [7722]. https://doi.org/10.3390/molecules27227722Test; Final; All Open Access; Gold Open Access; Green Open Access; https://www.mdpi.com/1420-3049/27/22/7722/pdf?version=1668585197Test; http://elar.urfu.ru/handle/10995/131329Test; 85142659494; 000887551600001

الإتاحة: https://doi.org/10.3390/molecules27227722Test
http://elar.urfu.ru/handle/10995/131329Test
https://www.mdpi.com/1420-3049/27/22/7722/pdf?version=1668585197Test

المؤلفون: Grishchenko, M. V., Makhaeva, G. F., Burgart, Ya. V., Boltneva, N. P., Rudakova, E. V., Zhilina, E. F., Shchegolkov, E. V., Kovaleva, N. V., Serebryakova, O. G., Saloutin, V. I., Charushin, V. N.

المصدر: Russian Chemical Bulletin; Dec2023, Vol. 72 Issue 12, p2994-3004, 11p

المؤلفون: Shchepochkin, A. V., Uglova, A. F., Utepova, I. A., Gradoblyanskaya, E. S., Averkov, M. A., Kovaleva, N. V., Rudakova, E. V., Boltneva, N. P., Serebryakova, O. G., Makhaeva, G. F., Charushin, V. N., Chupakhin, O. N.

المصدر: Doklady Chemistry; Apr2023, Vol. 509 Issue 2, p100-105, 6p

مصطلحات موضوعية: ACRIDINE derivatives, AMINE derivatives, CHEMICAL synthesis, NEURODEGENERATION, CHOLINESTERASES, ANTIOXIDANTS

المؤلفون: Shchegolkov, E. V., Boltneva, N. P., Burgart, Ya. V., Lushchekina, S. V., Serebryakova, O. G., Elkina, N. A., Rudakova, E. V., Perminova, A. N., Makhaeva, G. F., Saloutin, V. I.

المصدر: Russian Chemical Bulletin ; volume 71, issue 1, page 158-164 ; ISSN 1066-5285 1573-9171

مصطلحات موضوعية: General Chemistry

الإتاحة: https://doi.org/10.1007/s11172-022-3390-9Test

المؤلفون: Grishchenko, M. V., Elkina, N. A., Makhaeva, G. F., Burgart, Ya. V., Boltneva, N. P., Rudakova, E. V., Shchegolkov, E. V., Kovaleva, N. V., Serebryakova, O. G., Saloutin, V. I.

المصدر: Russian Journal of General Chemistry; Nov2022, Vol. 92 Issue 11, p2259-2266, 8p

مصطلحات موضوعية: TACRINE, BIOSYNTHESIS, MALONATES, ALZHEIMER'S disease, PROPIDIUM iodide, ACETYLCHOLINESTERASE inhibitors, MUSCARINIC receptors

المؤلفون: Elkina, N. A., Shchegolkov, E. V., Burgart, Ya. V., Saloutin, V. I., Boltneva, N. P., Serebryakova, O. G., Lushchekina, S. V., Makhaeva, G. F.

المصدر: Russian Chemical Bulletin ; volume 70, issue 3, page 567-572 ; ISSN 1066-5285 1573-9171

مصطلحات موضوعية: General Chemistry

الإتاحة: https://doi.org/10.1007/s11172-021-3126-2Test

المؤلفون: Makhaeva, G. F., Trofimova, T. P., Boltneva, N. P., Rudakova, E. V., Serebryakova, O. G., Lushchekina, S. V., Proshin, A. N., Bachurina, S. O.

المصدر: Russian Chemical Bulletin ; volume 66, issue 10, page 1897-1904 ; ISSN 1066-5285 1573-9171

مصطلحات موضوعية: General Chemistry

الإتاحة: https://doi.org/10.1007/s11172-017-1964-8Test