المؤلفون: Qadri, Sami, Vartiainen, Emilia, Lahelma, Mari, Porthan, Kimmo, Tang, An, Idilman, Ilkay S, Runge, Jurgen H, Juuti, Anne, Penttilä, Anne K, Dabek, Juhani, Lehtimäki, Tiina E, Seppänen, Wenla, Arola, Johanna, Arkkila, Perttu, Stoker, Jaap, Karcaaltincaba, Musturay, Pavlides, Michael, Loomba, Rohit, Sirlin, Claude B, Tukiainen, Taru, Yki-Järvinen, Hannele

المصدر: JHEP Reports. 6(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Liver Disease, Digestive Diseases, Oral and gastrointestinal, Fatty liver, Metabolic dysfunction-associated steatotic liver disease, Magnetic resonance imaging, Magnetic resonance spectroscopy, Biopsy, Histology, Hepatocytes, Pathologists, Triglycerides, Transcriptome, Systematic review, Meta-analysis, Clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8vr8h6b9Test

المؤلفون: Luukkonen, Panu K., Porthan, Kimmo, Ahlholm, Noora, Rosqvist, Fredrik, Dufour, Sylvie, Zhang, Xian Man, Lehtimäki, Tiina E., Seppänen, Wenla, Orho-Melander, Marju, Hodson, Leanne, Petersen, Kitt Falk, Shulman, Gerald I., Yki-Järvinen, Hannele

المصدر: Cell Metabolism EpiHealth: Epidemiology for Health EXODIAB: Excellence of Diabetes Research in Sweden. 35(11):5-1896

مصطلحات موضوعية: GDF-15, ketogenic diet, mitochondrial dysfunction, NAD+, NADH, NAFLD, NASH, patatin-like phospholipase domain containing protein 3, redox, reductive stress, Medicin och hälsovetenskap, Klinisk medicin, Gastroenterologi, Medical and Health Sciences, Clinical Medicine, Gastroenterology and Hepatology

الوصول الحر: https://lup.lub.lu.se/record/95b1d0a2-c837-4af4-ad42-92fb48bad9ecTest
http://dx.doi.org/10.1016/j.cmet.2023.10.008Test

المؤلفون: Luukkonen, Panu K., Porthan, Kimmo, Ahlholm, Noora, Rosqvist, Fredrik, Dufour, Sylvie, Zhang, Xian Man, Lehtimäki, Tiina E., Seppänen, Wenla, Orho-Melander, Marju, Hodson, Leanne, Petersen, Kitt Falk, Shulman, Gerald I., Yki-Järvinen, Hannele

المساهمون: Department of Medicine, HUS Abdominal Center, HUS Helsinki and Uusimaa Hospital District, Clinicum, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, HUS Diagnostic Center, HUS Internal Medicine and Rehabilitation

مصطلحات موضوعية: GDF-15, ketogenic diet, mitochondrial dysfunction, NAD+, NADH, NAFLD, NASH, patatin-like phospholipase domain containing protein 3, redox, reductive stress, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: The authors wish to thank Aila Karioja-Kallio, Päivi Ihamuotila, Irina Smolgovsky, and John Stack for their excellent technical assistance. This study was supported by grants from the Academy of Finland ( 309263 to H.Y.-J. and 350545 P.K.L.), the Sigrid Jusélius Foundation (H.Y.-J. and P.K.L.), the Novo Nordisk Foundation ( NNF19OC0057503 to H.Y.-J. and NNF18OC0054504 to P.K.L.), U.S. Department of Health & Human Services , NIH/NIDDK ( R01 DK113984 and R01 DK119968 to G.I.S.), and the Yale Diabetes Research Center ( P30 DK045735 to G.I.S.). The participants for the research were partially recruited from THL Biobank (study number: THLBB2020_3). We thank all study participants for their generous participation in biobank research. The authors wish to thank Aila Karioja-Kallio, Päivi Ihamuotila, Irina Smolgovsky, and John Stack for their excellent technical assistance. This study was supported by grants from the Academy of Finland (309263 to H.Y.-J. and 350545 P.K.L.), the Sigrid Jusélius Foundation (H.Y.-J. and P.K.L.), the Novo Nordisk Foundation (NNF19OC0057503 to H.Y.-J. and NNF18OC0054504 to P.K.L.), U.S. Department of Health & Human Services, NIH/NIDDK (R01 DK113984 and R01 DK119968 to G.I.S.), and the Yale Diabetes Research Center (P30 DK045735 to G.I.S.). The participants for the research were partially recruited from THL Biobank (study number: THLBB2020_3). We thank all study participants for their generous participation in biobank research. Conceptualization, P.K.L. H.Y.-J. G.I.S. K.F.P. and L.H.; investigation, P.K.L. K.P. N.A. F.R. S.D. X.-M.Z. T.E.L. W.S. and M.O.-M.; writing – original draft, P.K.L.; writing – review & editing, P.K.L. K.P. N.A. F.R. S.D. X.-M.Z. T.E.L. W.S. M.O.-M. L.H. K.F.P. G.I.S. and H.Y.-J.; supervision, H.Y.-J. and G.I.S. The authors declare no competing interests.; Luukkonen , P K , Porthan , K , Ahlholm , N , Rosqvist , F , Dufour , S , Zhang , X M , Lehtimäki , T E , Seppänen , W , Orho-Melander , M , Hodson , L , Petersen , K F , Shulman , G I & Yki-Järvinen , H 2023 , ' The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans ' , Cell Metabolism , vol. 35 , no. 11 , pp. 1887-+ . https://doi.org/10.1016/j.cmet.2023.10.008Test; 85175563210; 57e8c66a-9f3c-4c46-a7ed-2caa588043a7; http://hdl.handle.net/10138/569331Test; 001109869300001

الإتاحة: http://hdl.handle.net/10138/569331Test

المؤلفون: Qadri, Sami, Vartiainen, Emilia, Lahelma, Mari, Porthan, Kimmo, Tang, An, Idilman, Ilkay S., Runge, Jurgen H., Juuti, Anne, Penttilä, Anne K., Dabek, Juhani, Lehtimäki, Tiina E., Seppänen, Wenla, Arola, Johanna, Arkkila, Perttu, Stoker, Jaap, Karcaaltincaba, Musturay, Pavlides, Michael, Loomba, Rohit, Sirlin, Claude B., Tukiainen, Taru, Yki-Järvinen, Hannele

المساهمون: Department of Medicine, HUS Internal Medicine and Rehabilitation, Institute for Molecular Medicine Finland, HUS Helsinki and Uusimaa Hospital District, HUS Abdominal Center, II kirurgian klinikka, Clinicum, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, HUS Diagnostic Center, HUSLAB, Department of Pathology, Gastroenterologian yksikkö, Genomics of Sex Differences, Molecular and Integrative Biosciences Research Programme, University of Helsinki

مصطلحات موضوعية: Biopsy, Fatty liver, Hepatocytes, Histology, Magnetic resonance imaging, Magnetic resonance spectroscopy, Meta-analysis, Metabolic dysfunction-associated steatotic liver disease, Pathologists, Systematic review, Transcriptome, Triglycerides, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: We gratefully acknowledge the volunteers for their help and thank Aila Karioja-Kallio and Päivi Ihamuotila for their excellent technical assistance. Fig. 5 was created with BioRender.com . Open access funded by Helsinki University Library. HYJ was supported by grants from the Academy of Finland (no. 309263 ), the Novo Nordisk Foundation , and the Sigrid Jusélius Foundation . SQ was supported by grants from the Orion Research Foundation , the Yrjö Jahnsson Foundation , the Maud Kuistila Memorial Foundation , the Emil Aaltonen Foundation , and the Finnish Medical Foundation . TT was supported by grants from the Academy of Finland (no. 315589 and no. 320129 ) and the Sigrid Jusélius Foundation . RL receives funding support from NCATS ( 5UL1TR001442 ), NIDDK ( U01DK061734 , U01DK130190 , R01DK106419 , R01DK121378 , R01DK124318 , P30DK120515 ), NHLBI ( P01HL147835 ), and NIAAA ( U01AA029019 ). AT was supported by a Senior Clinical Research Scholarship from the Fonds de recherche du Québec en Santé and Fondation de l'association des radiologistes du Québec Clinical Research Scholarship (FRQS-ARQ #298509). MP acknowledges support from the Oxford NIHR Biomedical Research Centre.; HYJ was supported by grants from the Academy of Finland (no. 309263),the Novo Nordisk Foundation, and the Sigrid Juselius Foundation. SQ wassupported by grants from the Orion Research Foundation, the YrjoeJahnsson Foundation, the Maud Kuistila Memorial Foundation, the EmilAaltonen Foundation, and the Finnish Medical Foundation. TT was supported by grants from the Academy of Finland (no. 315589 and no.320129) and the Sigrid Juselius Foundation. RL receives funding support from NCATS (5UL1TR001442), NIDDK (U01DK061734, U01DK130190,R01DK106419, R01DK121378, R01DK124318, P30DK120515), NHLBI(P01HL147835), and NIAAA (U01AA029019). AT was supported by a Senior Clinical Research Scholarship from the Fonds de recherche du Quebec en Sante and Fondation de l'association des radiologistes du Quebec Clinical Research Scholarship (FRQS-ARQ #298509). MP acknowledges support from the Oxford NIHR Biomedical Research Centre; Qadri , S , Vartiainen , E , Lahelma , M , Porthan , K , Tang , A , Idilman , I S , Runge , J H , Juuti , A , Penttilä , A K , Dabek , J , Lehtimäki , T E , Seppänen , W , Arola , J , Arkkila , P , Stoker , J , Karcaaltincaba , M , Pavlides , M , Loomba , R , Sirlin , C B , Tukiainen , T & Yki-Järvinen , H 2024 , ' Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction : A meta-analysis ' , JHEP reports , vol. 6 , no. 1 , 100928 . https://doi.org/10.1016/j.jhepr.2023.100928Test; ORCID: /0000-0001-9313-9324/work/150796814; 85178135995; 35d18e82-5721-4559-8981-f2f404c3a68e; http://hdl.handle.net/10138/568402Test; 001128626500001

الإتاحة: http://hdl.handle.net/10138/568402Test

المؤلفون: Vartiainen, Emilia, Yki-Järvinen, Hannele, Tukiainen, Taru, Sirlin, Claude B., Loomba, Rohit, Pavlides, Michael, Karcaaltincaba, Musturay, Stoker, Jaap, Arkkila, Perttu, Arola, Johanna, Seppänen, Wenla, Lehtimäki, Tiina E., Dabek, Juhani, Penttilä, Anne K., Juuti, Anne, Runge, Jurgen H., İDİLMAN, İLKAY SEDAKAT, Tang, An, Porthan, Kimmo, Lahelma, Mari, Qadri, Sami

العلاقة: 5e1ac102-8222-4d7d-a652-949fc399dc4a; https://avesis.hacettepe.edu.tr/publication/details/5e1ac102-8222-4d7d-a652-949fc399dc4a/oaiTest

الإتاحة: https://doi.org/10.1016/j.jhepr.2023.100928Test
https://avesis.hacettepe.edu.tr/publication/details/5e1ac102-8222-4d7d-a652-949fc399dc4a/oaiTest

المؤلفون: Qadri, Sami, Porthan, Kimmo, Juuti, Anne, Penttilä, Anne, Dabek, Juhani, Lehtimäki, Tiina E., Seppänen, Wenla, Arola, Johanna, Arkkila, Perttu, Yki-Järvinen, Hannele

المصدر: Journal of Hepatology ; volume 77, page S458 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(22)01246-6
https://api.elsevier.com/content/article/PII:S0168827822012466?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827822012466?httpAccept=text/plainTest

المؤلفون: Luukkonen, Panu, Porthan, Kimmo, Ahlholm, Noora, Rosqvist, Fredrik, Dufour, Sylvie, Zhang, Xian-Man, Dabek, Juhani, Lehtimäki, Tiina, Seppänen, Wenla, Orho-Melander, Marju, Hodson, Leanne, Petersen, Kitt Falk, Shulman, Gerald I., Yki-Järvinen, Hannele

المصدر: Journal of Hepatology ; volume 77, page S690-S691 ; ISSN 0168-8278

مصطلحات موضوعية: Hepatology

الإتاحة: https://doi.org/10.1016/s0168-8278Test(22)01698-1
https://api.elsevier.com/content/article/PII:S0168827822016981?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0168827822016981?httpAccept=text/plainTest