التفاصيل البيبلوغرافية
| العنوان: |
LADA prevalence estimation and insulin dependency during follow-up |
| المؤلفون: |
Yongsoo Park, Jungtaek Woo, Munsuk Nam, Leejin Park, Sangmo Hong, Young-Seol Kim, Sehyun Baik, Kwan Woo Lee |
| المصدر: |
Diabetes/metabolism research and reviews. 27(8) |
| سنة النشر: |
2011 |
| مصطلحات موضوعية: |
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Type 2 diabetes, Zinc Transporter 8, Endocrinology, Insulin resistance, Asian People, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Prevalence, Humans, Insulin, Prospective Studies, education, Cation Transport Proteins, Aged, Autoantibodies, education.field_of_study, Korea, business.industry, Glutamate Decarboxylase, Incidence (epidemiology), Autoantibody, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Immunology, Cohort, Disease Progression, Female, Insulin Resistance, business, Follow-Up Studies |
| الوصف: |
Background Latent autoimmune diabetes in adults (LADA) is a form of autoimmune-mediated diabetes in adults, usually defined by GAD autoantibody positivity. Few epidemiological surveys on LADA in Asians did not come to a conclusive answer regarding prevalence and incidence, because of different criteria used in patient ascertainment. Methods We estimated LADA prevalence in a recent type 2 diabetes cohort by the positivity of circulating autoantibodies to pancreatic islet cell antigens (GAD, IA-2 and zinc transporter 8 (ZnT8)) applying a comparable Caucasian criteria. We then observed the development of insulin dependency prospectively for 36 months. Results Applying the European NIRAD LADA group criteria, we found a high prevalence of LADA (4.4%) in Korean patients with phenotypic type 2 diabetes. This high prevalence of LADA in Korea is noteworthy since the previous population-based LADA prevalence survey reported low prevalence (1.7%). When we consider the low-titre GAD antibodies and the low prevalence of multiple autoantibodies, however, increased LADA prevalence does not necessarily mean increase in future insulin dependency. After 36 months of follow-up, only 3 of 39 patients who were initially classified as LADA have become insulin-dependent. Those three were all positive for multiple autoantibodies (GAD, IA-2 and zinc transporter 8 antibody). Other features of insulin secretion or insulin resistance did not determine future insulin necessity. Conclusions Although the LADA prevalence estimated by anti-GAD positivity appeared to increase, the true insulin dependency evidenced by multiple antibody positivity did not increase in Korea. Copyright © 2011 John Wiley & Sons, Ltd. |
| تدمد: |
1520-7560 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ca3049e39d7646af1561159b6d3e0bTest
https://pubmed.ncbi.nlm.nih.gov/22069296Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....13ca3049e39d7646af1561159b6d3e0b |
| قاعدة البيانات: |
OpenAIRE |
