المؤلفون: Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossmann, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Guebeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/380bf3f0f3d44554830c4469d686c355Test

المؤلفون: Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Gaetano Marrone, Sebastian Grossmann, Ujjwal Neogi, Belete Tegbaru, Anders Sönnerborg

المصدر: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: HIV-1 drug resistance, Near-full length genome, Genome wide association, Antiretroviral therapy, Countrywide HIV cohort, Ethiopia, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12879-019-4196-8Test; https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/b0587b4c4d184371a73a8239506ae58eTest

المؤلفون: Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe

المصدر: Molecular Systems Biology, Vol 15, Iss 5, Pp n/a-n/a (2019)

مصطلحات موضوعية: bivalent promoter, DNA methylation, enhancer, gene regulatory networks, histone modifications, Biology (General), QH301-705.5, Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1744-4292Test

الوصول الحر: https://doaj.org/article/d531e1d3965044bc9b7dc0b0a7049c9aTest

المؤلفون: Belete Tegbaru, Gaetano Marrone, Sebastian Grossmann, Solomon Gebre-Selassie, Anders Sönnerborg, Daniel Fekade, Amare Worku Kalu, Ujjwal Neogi, Nigus Fikrie Telele

المصدر: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Infectious Diseases

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Genotype, Anti-HIV Agents, 030106 microbiology, HIV Infections, Genome-wide association study, HIV Integrase, Drug resistance, lcsh:Infectious and parasitic diseases, Cohort Studies, Near-full length genome, 03 medical and health sciences, Zidovudine, 0302 clinical medicine, Medical microbiology, Internal medicine, Drug Resistance, Viral, medicine, Humans, lcsh:RC109-216, Treatment Failure, 030212 general & internal medicine, Tenofovir, business.industry, virus diseases, Countrywide HIV cohort, Antiretroviral therapy, Reverse transcriptase, 3. Good health, Infectious Diseases, Parasitology, Mutation, Cohort, HIV-1, Genome wide association, Reverse Transcriptase Inhibitors, Female, Ethiopia, business, HIV-1 drug resistance, Research Article, Genome-Wide Association Study, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad3fb2bff3d1cf722480eec11b2f7fTest
http://link.springer.com/article/10.1186/s12879-019-4196-8Test

المؤلفون: Elisa Laurenti, Anthony R. Green, Michael R. Stratton, Nina F. Øbro, Mairi Shepherd, Henry Lee-Six, Sebastian Grossmann, Kevin J. Dawson, Inigo Martincorena, David G. Kent, Robert J. Osborne, Peter J. Campbell, Brian J. P. Huntly, Laura O’Neill, Elizabeth Anderson, Miriam Belmonte

المساهمون: Shepherd, Mairi [0000-0002-4328-9882], Huntly, Brian [0000-0003-0312-161X], Laurenti, Elisa [0000-0002-9917-9092], Green, Tony [0000-0002-9795-0218], Kent, David [0000-0001-7871-8811], Apollo - University of Cambridge Repository

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Time Factors, Cell division, Somatic cell, DNA Mutational Analysis, Population, Embryonic Development, Cell Count, Biology, medicine.disease_cause, Article, 03 medical and health sciences, medicine, Humans, Cell Lineage, Lymphocytes, education, health care economics and organizations, Progenitor, education.field_of_study, Mutation, Blood Cells, Multidisciplinary, Genome, Human, Bayes Theorem, Middle Aged, Hematopoietic Stem Cells, Clone Cells, Hematopoiesis, 3. Good health, Cell biology, Adult Stem Cells, Haematopoiesis, 030104 developmental biology, Stem cell, Cell Division, Granulocytes, Adult stem cell

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e59697b90528b553cc0b3747803db9Test
https://doi.org/10.1038/s41586-018-0497-0Test

المؤلفون: Laura O’Neill, Laura Wilson, Peter J. Campbell, Sebastian Grossmann, Michael R. Stratton, Thierry Voet, Rakesh Heer, Luiza Moore, Inigo Martincorena, Yvette Hooks

المصدر: Cell stem cell. 28(7)

مصطلحات موضوعية: SELECTION, Adult, Male, Aging, Somatic cell, BENIGN, Clone (cell biology), Biology, medicine.disease_cause, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Cell & Tissue Engineering, REVEALS, Genetics, medicine, Humans, BASAL, HETEROGENEITY, Phylogeny, 030304 developmental biology, 0303 health sciences, Mutation, Science & Technology, IDENTIFICATION, ORIGIN, Stem Cells, Cell Biology, LINEAGE, Middle Aged, medicine.disease, Embryonic stem cell, CANCER, Epithelium, medicine.anatomical_structure, EPITHELIAL STEM-CELL, Cancer research, Molecular Medicine, Stem cell, Life Sciences & Biomedicine, 030217 neurology & neurosurgery

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7449ed611537b5efec1b24a6009b0766Test
https://pubmed.ncbi.nlm.nih.gov/34214437Test

المؤلفون: Sabrina Kugler, Fabian Erdel, Sebastian Großmann, Jose M. Muiño, Daniele Tavernari, Lara Klett, Sandra D Koser, Martin Vingron, Daniel Remondini, Marc Zapatka, Jan-Philipp Mallm, Rainer König, Stephan Stilgenbauer, Peter Lichter, Karsten Rippe, Benedikt Brors, Vladimir B. Teif, Alexandra M Poos, Sabrina Schumacher, Naveed Ishaque, Murat Iskar, Daniel Mertens

المساهمون: Mallm J.-P., Iskar M., Ishaque N., Klett L.C., Kugler S.J., Muino J.M., Teif V.B., Poos A.M., Grossmann S., Erdel F., Tavernari D., Koser S.D., Schumacher S., Brors B., Konig R., Remondini D., Vingron M., Stilgenbauer S., Lichter P., Zapatka M., Mertens D., Rippe K.

المصدر: Molecular Systems Biology, Vol 15, Iss 5, Pp n/a-n/a (2019)
Molecular Systems Biology
Molecular Systems Biology, vol. 15, no. 5, pp. e8339

مصطلحات موضوعية: CCCTC-Binding Factor, Medicine (General), DNS, Amino Acid Motifs, gene regulatory network, Chromatin, Epigenetics, Genomics & Functional Genomics, Gene regulatory networks, Histones, 0302 clinical medicine, hemic and lymphatic diseases, Biology (General), Promoter Regions, Genetic, Chronisch-lymphatische Leuk��mie, Cancer, 0303 health sciences, DNA methylation, biology, Gene Expression Regulation, Leukemic, histone modifications, Applied Mathematics, Articles, Middle Aged, Chromatin, 3. Good health, Cell biology, Enhancer Elements, Genetic, Histone, Computational Theory and Mathematics, Genome-Scale & Integrative Biology, Chronisch-lymphatische Leukämie, Histone deacetylase activity, General Agricultural and Biological Sciences, Protein Binding, Information Systems, QH301-705.5, bivalent promoter, enhancer, gene regulatory networks, Down-Regulation, Article, Histone Deacetylases, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, R5-920, Humans, Nucleosome, Epigenetics, ddc:610, Enhancer, Aged, 030304 developmental biology, Binding Sites, General Immunology and Microbiology, DNA, Leukemia, Lymphocytic, Chronic, B-Cell, Methylierung, CTCF, Trans-Activators, biology.protein, DDC 610 / Medicine & health, 030217 neurology & neurosurgery

وصف الملف: application/pdf; ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98673e115bf3ab7f66dc50c8fb7b7c0cTest

المؤلفون: David C. Wedge, Michael R. Stratton, Kevin J. Dawson, Sebastian Grossmann, Peter J. Campbell, Jonathan S. Brammeld, Ilias Georgakopoulos-Soares, Young Seok Ju, Sarah O’Meara, Keiran Raine, Calli Latimer, Francesco Iorio, Bee Ling Ng, Burcak Otlu, Kathryn Beal, Jorge Zamora, Adam Butler, Shriram G. Bhosle, Bernardo Rodriguez-Martin, Jennifer Graham, Jon W. Teague, Mark Maddison, Elizabeth Anderson, Nikita Patel, Ludmil B. Alexandrov, Ultan McDermott, Mathew J. Garnett, David Jones, Ching Chiek Koh, Andrew Menzies, Stacey Price, Laura O’Neill, Serena Nik-Zainal, Mia Petljak, Jose M. C. Tubio

المساهمون: Nik-Zainal Abidin, Serena [0000-0001-5054-1727], Apollo - University of Cambridge Repository, Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física

المصدر: Cell
Petljak, M, Alexandrov, L B, Brammeld, J S, Price, S, Wedge, D C, Grossmann, S, Dawson, K J, Ju, Y S, Iorio, F, Tubio, J M C, Koh, C C, Georgakopoulos-Soares, I, Rodríguez-Martín, B, Otlu, B, O'Meara, S, Butler, A P, Menzies, A, Bhosle, S G, Raine, K, Jones, D R, Teague, J W, Beal, K, Latimer, C, O'Neill, L, Zamora, J, Anderson, E, Patel, N, Maddison, M, Ng, B L, Graham, J, Garnett, M J, McDermott, U, Nik-Zainal, S, Campbell, P J & Stratton, M R 2019, ' Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis ', Cell . https://doi.org/10.1016/j.cell.2019.02.012Test
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

مصطلحات موضوعية: APOBEC, Mutation rate, DNA Copy Number Variations, Mutational signatures, Somatic hypermutation, mutational signatures, Biology, Article, General Biochemistry, Genetics and Molecular Biology, episodic mutagenesis, 03 medical and health sciences, 0302 clinical medicine, APOBEC Deaminases, Ultraviolet light, Humans, Exome, Proteogenomics, 030304 developmental biology, Genetics, Human cancer cell, 0303 health sciences, cancer cell lines, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Mutagenesis, APOBEC deaminases, Cytidine deaminase, Thoracic Neoplasms, 3. Good health, xenografts, Mutation, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef46c3ac8f2812db476d77816fba4765Test
https://www.repository.cam.ac.uk/handle/1810/291718Test

المؤلفون: Getachew Aderaye, Wondwossen Amogne, Ujjwal Neogi, Anders Sönnerborg, Irene Bontell, Lars Lindquist, Sebastian Grossmann

المصدر: AIDS Research and Human Retroviruses. 32:471-474

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Genome, Viral, Microbial Sensitivity Tests, Biology, medicine.disease_cause, gag Gene Products, Human Immunodeficiency Virus, Genome, 03 medical and health sciences, Phylogenetics, Virology, Drug Resistance, Viral, Genotype, medicine, Humans, Phylogeny, Tropism, Subgenomic mRNA, Genetics, Polymorphism, Genetic, Base Sequence, Geography, Phylogenetic tree, Sequence Analysis, RNA, env Gene Products, Human Immunodeficiency Virus, virus diseases, 030104 developmental biology, Infectious Diseases, Geographical cluster, pol Gene Products, Human Immunodeficiency Virus, HIV-1, RNA, Viral, Female, Ethiopia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd00ac06c707f39a01ae78769e3dfad9Test
https://doi.org/10.1089/aid.2015.0380Test

المؤلفون: Nobuo Sasaki, Niels Smakman, Joost van Gorp, Howard Lightfoot, Sebastian Grossmann, Marc van de Wetering, Matthew D. Young, Ludmil B. Alexandrov, Henry Lee-Six, David A. Egan, Hans Clevers, Stephen J. Gamble, Michael R. Stratton, Sam Behjati, Apollo Pronk, Thomas J. Mitchell, Peter J. Campbell, Sophie F. Roerink, Elizabeth Anderson, Chris Alder

المساهمون: Mitchell, Thomas [0000-0003-0761-9503], Apollo - University of Cambridge Repository, Hubrecht Institute for Developmental Biology and Stem Cell Research

المصدر: Nature, 556(7702), 457-462. Nature Publishing Group
Nature, 556(7702), 437. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, Evolution, Colorectal cancer, DNA Mutational Analysis, Antineoplastic Agents, Biology, medicine.disease_cause, Evolution, Molecular, 03 medical and health sciences, Germline mutation, Single-cell analysis, Mutation Rate, medicine, Humans, Intestinal Mucosa, General, Cell Proliferation, Neoplastic, Mutation, Multidisciplinary, Molecular, Cancer, Colorectal Neoplasms/drug therapy, DNA Methylation, medicine.disease, Clone Cells, Gene Expression Regulation, Neoplastic, Intestines, Organoids, Clone Cells/drug effects, 030104 developmental biology, Gene Expression Regulation, Cancer cell, DNA methylation, Cancer research, Neoplastic cell, Organoids/cytology, Single-Cell Analysis, Colorectal Neoplasms, Transcriptome, Antineoplastic Agents/pharmacology, Intestinal Mucosa/metabolism, Intestines/cytology

وصف الملف: application/msword; image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86095edf3cb2089e7a0f52c05acb987cTest
https://www.repository.cam.ac.uk/handle/1810/273566Test