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1دورية أكاديمية
المؤلفون: Gary M. Chinigo, Emma L. McInturff, Scott W. Bagley, Richard W. Barnhart, David C. Blakemore, Lu Han, Taegyo Lee, Javier Magano, J. Christopher McWilliams, Sebastien Monfette, James J. Mousseau, Senliang Pan, Dylan Pedro, Hahdi H. Perfect, Jeffrey W. Raggon, Peter R. Rose, John Sagal, John I. Trujillo, Jared Van Haitsma, Michael G. Vetelino, Xiaojing Helen Yang
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Sociology, Immunology, Computational Biology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, two elaborated amines, sulfinimine addition reaction, sterically congested amine, low yield due, highlighted improvements made, early process development, target molecule, subsequent enablement, sequential substitution, previously suffered, poor regioselectivity, original synthesis, kilogram manufacture, key iodopyrazole, high stereocontrol, enablement efforts, efficient construction, diethyl squarate, crystalline api, campaign include
الإتاحة: https://doi.org/10.1021/acs.oprd.3c00451.s001Test
https://figshare.com/articles/journal_contribution/Early_Process_Development_of_PF-07054894_a_Squaramide-Based_Antagonist_of_C_C_Chemokine_Receptor_Type_6_CCR6_/25109284Test -
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المصدر: Chem.
مصطلحات موضوعية: General Chemical Engineering, Biochemistry (medical), Materials Chemistry, Environmental Chemistry, General Chemistry, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bc55362521e95a70ac4dccdd1697d47cTest
https://doi.org/10.1016/j.chempr.2023.04.008Test -
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المؤلفون: Qi Yukki Li, Samuel N. Gockel, Grace A. Lutovsky, Kimberly S. DeGlopper, Neil J. Baldwin, Mark W. Bundesmann, Joseph W. Tucker, Scott W. Bagley, Tehshik P. Yoon
المصدر: Nat Chem
مصطلحات موضوعية: Light, General Chemical Engineering, Carboxylic Acids, General Chemistry, Ligands, Oxidation-Reduction, Copper, Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d697ac258564214080ab5362fd1e1e0Test
https://doi.org/10.1038/s41557-021-00834-8Test -
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المؤلفون: David A. Griffith, David J. Edmonds, Jean-Philippe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, Jayesh C. Patel, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess
المصدر: Journal of medicinal chemistry. 65(12)
مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Animals, Humans, Hypoglycemic Agents, Peptides, Glucagon-Like Peptide-1 Receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff991134db369ff3aa7ceaecc2f6263eTest
https://pubmed.ncbi.nlm.nih.gov/35647711Test -
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المؤلفون: Shawn D. Doran, Jana Polivkova, James A. Southers, Scott W. Bagley, Kim Huard, Dilinie P. Fernando, Manthena V.S. Varma, David A. Beebe, David J. Edmonds, Robert L. Dow, Benjamin A. Thuma, Collin Crowley, William P. Esler, Trenton T. Ross, David A. Tess, Mark Niosi, Amit S. Kalgutkar, Jeffrey A. Pfefferkorn, Norimitsu Shirai, David A. Griffith, Shawn Cabral, Andrew H. Smith, Gregg D. Cappon, Vincent Mascitti, Matthew S. Dowling, Andre Shavnya, David Price, Ayman El-Kattan, Aaron C. Smith, Yi-an Bi, Spiros Liras, Xiaojing Helen Yang, Cathy Préville
المصدر: Journal of Medicinal Chemistry. 63:10879-10896
مصطلحات موضوعية: Pharmacology, 01 natural sciences, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, Non-alcoholic Fatty Liver Disease, Drug Discovery, medicine, Animals, Humans, Platelet, Enzyme Inhibitors, Fatty acid synthesis, 030304 developmental biology, 0303 health sciences, biology, Lipogenesis, Acetyl-CoA carboxylase, Lipid metabolism, 0104 chemical sciences, Pyruvate carboxylase, Organic anion-transporting polypeptide, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Liver, chemistry, biology.protein, Molecular Medicine, Bone marrow, Acetyl-CoA Carboxylase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07da4330450bd15b2bafcbaadc0cc94bTest
https://doi.org/10.1021/acs.jmedchem.0c00640Test -
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المؤلفون: J. Brent Kuzmiski, João M. Dias, Seungil Han, Chris Limberakis, David Price, David J. Edmonds, John M. Curto, Amit S. Kalgutkar, Daniel J. Lettiere, David A. Tess, Clare Buckeridge, Matthew C. Griffor, David R. Derksen, Alan M. Mathiowetz, Roger B. Ruggeri, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Yuhang Liu, Margaret S. Landis, David W. Piotrowski, V. Margaret Jackson, David A. Griffith, Jean-Phillipe Fortin
مصطلحات موضوعية: chemistry.chemical_classification, Agonist, Chemistry, medicine.drug_class, Insulin, medicine.medical_treatment, Endogeny, Peptide, Pharmacology, Small molecule, Glucagon-like peptide-1, Oral administration, medicine, Receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bfTest
https://doi.org/10.1101/2020.09.29.319483Test -
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المؤلفون: Rongbiao Tong, Daniel P. Canterbury, Xiayun Cheng, Alexandria P. Taylor, Guodong Zhao, Scott W. Bagley, Peter Mikochik
المصدر: Organic letters. 22(2)
مصطلحات موضوعية: chemistry, 010405 organic chemistry, Organic Chemistry, Substrate (chemistry), chemistry.chemical_element, Physical and Theoretical Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Palladium, Catalysis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b2ac8e7f4f8379a3d438d1f7230ce3Test
https://pubmed.ncbi.nlm.nih.gov/31880455Test -
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المؤلفون: Daniel W. Kung, James A. Southers, Shawn Cabral, Carmen N. Garcia-Irizarry, Aaron C. Smith, Colin R. Rose, Scott W. Bagley, David A. Griffith, David B. Damon
المصدر: The Journal of Organic Chemistry. 81:3509-3519
مصطلحات موضوعية: Nitrile, 010405 organic chemistry, Organic Chemistry, Azetidine, Alkylation, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Reductive amination, Pyrrolidine, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Organic chemistry, Piperidine, Enantiomer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7345ad0818e90d8d739ba260a4326126Test
https://doi.org/10.1021/acs.joc.5b02890Test -
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المؤلفون: Angela Wolford, Heather Eng, Yanwei Zhang, Suvi T. M. Orr, Kay Ahn, Daniel W. Widlicka, Carlin Okerberg, Amit S. Kalgutkar, Yingmei Qi, Samantha N. Spath, Paul D. Bonin, Dilinie P. Fernando, Aaron C. Smith, Tim F. Ryder, Karen Walters, Yan Zhang, David Hepworth, Wenhua Jiao, Joseph S. Warmus, Benjamin N. Rocke, Tristan S. Maurer, Daniel Merritt Bowles, Daniel W. Kung, Scott W. Bagley, Philip A. Carpino, Roger B. Ruggeri, Gang Xing, Leonard Buckbinder, Edward L. Conn, Matthew S. Dowling, Raman Sharma
المصدر: Journal of Medicinal Chemistry. 58:8513-8528
مصطلحات موضوعية: biology, Hypochlorous acid, Chemistry, Cytochrome P450, Pyrimidinones, chemistry.chemical_compound, Biochemistry, Cardiovascular Diseases, Oral administration, Myeloperoxidase, Acetamides, Drug Discovery, biology.protein, Animals, Humans, Molecular Medicine, Enzyme Inhibitors, Rats, Wistar, Lead compound, Acetamide, Peroxidase, Whole blood
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac30d6c8fa4af6183864fd024f9b6afTest
https://doi.org/10.1021/acs.jmedchem.5b00963Test -
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المؤلفون: Anthony Carlo, Matthew S. Dowling, Michael John Munchhof, Robert L. Dow, David Price, Aaron C. Smith, Donna N. Petersen, Athanasia Skoura, Christian Cortes, Allyn T. Londregan, Leonard Buckbinder, Jian Wang, Shenping Liu, Kristen Ford, Samit Kumar Bhattacharya, Paula M. Loria, David Hepworth, Cristiano Ruch Werneck Guimarães, Mark Ammirati, Alan M. Mathiowetz, Wenhua Jiao, Jennifer L. LaPerle, Scott W. Bagley, Ayman El-Kattan, Suvi T. M. Orr, Rebecca Conrad
المصدر: ACS Medicinal Chemistry Letters. 6:1128-1133
مصطلحات موضوعية: In vivo, Proof of concept, Organic Chemistry, Drug Discovery, Adipose tissue, Antidiabetic treatment, Kinome, Pharmacology, Biology, Protein kinase A, Biochemistry, Transferase inhibitor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c7dc48671313aa67336c68fdaefadeTest
https://doi.org/10.1021/acsmedchemlett.5b00215Test