المؤلفون: Pavlic, A., Poelman, H., Wasilewski, G., Wichapong, K., Lux, P., Maassen, C., Lutgens, E., Schurgers, L.J., Reutelingsperger, C.P., Nicolaes, G.A.F.

المصدر: Pavlic , A , Poelman , H , Wasilewski , G , Wichapong , K , Lux , P , Maassen , C , Lutgens , E , Schurgers , L J , Reutelingsperger , C P & Nicolaes , G A F 2023 , ' Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification ' , International Journal of Molecular Sciences , vol. 24 , no. 3 , 2027 . https://doi.org/10.3390/ijms24032027Test

مصطلحات موضوعية: drug discovery, virtual ligand screening, vascular calcification, SMPD3, nSMase2, small molecules, extracellular vesicles, C2 DOMAIN, DISCOVERY, DESIGN, PREDICTION, PRECISION, MECHANISM, DOCKING, CALCIUM, DISEASE, SURFLEX

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/a0fa20a7-7d28-4977-a1c7-9c1f65721721Test

الإتاحة: https://doi.org/10.3390/ijms24032027Test
https://cris.maastrichtuniversity.nl/en/publications/a0fa20a7-7d28-4977-a1c7-9c1f65721721Test

المؤلفون: van Kuijk, K., McCracken, I.R., Tillie, R.J.H.A., Asselberghs, S.E.J., Kheder, D.A., Muitjens, S., Jin, H., Taylor, R.S., Schreur, R.W., Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M.J., Temmerman, L., Kirkwoord, P.M., Luyten, J., Li, Y.M., Noels, H., Goossens, P., Wilson-Kanamori, J.R., Schurgers, L.J., Shen, Y.H., Mees, B.M.E., Biessen, E.A.L., Henderson, N.C., Kramann, R., Baker, A.H., Sluimer, J.C.

المصدر: van Kuijk , K , McCracken , I R , Tillie , R J H A , Asselberghs , S E J , Kheder , D A , Muitjens , S , Jin , H , Taylor , R S , Schreur , R W , Kuppe , C , Dobie , R , Ramachandran , P , Gijbels , M J , Temmerman , L , Kirkwoord , P M , Luyten , J , Li , Y M , Noels , H , Goossens , P , Wilson-Kanamori , J R , Schurgers , L J , ....

مصطلحات موضوعية: Adventitia, Fibroblasts, Heterogeneity, Atherosclerosis, Single-cell RNA-seq, LYSYL OXIDASE, SMOOTH-MUSCLE, VEIN GRAFTS, HYPERTENSION, ENZYME

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/ca4a6756-3f2a-4932-a5d2-324750d362c0Test

الإتاحة: https://doi.org/10.1093/cvr/cvad016Test
https://cris.maastrichtuniversity.nl/en/publications/ca4a6756-3f2a-4932-a5d2-324750d362c0Test

المؤلفون: van den Akker, G.G.H., Steijns, J.S.J.J., Stassen, R.H.M.J., Wasilewski, G.B., Peeters, L.C.W., Wijnands, K.A.P., Schurgers, L.J., Caron, M.M.J., van Rhijn, L.W., Welting, T.J.M.

المساهمون: Dutch Arthritis Association, H2020 Marie Skłodowska-Curie Actions, Horizon 2020, European Commission, Norges Forskningsråd, ReumaNederland, Stichting De Weijerhorst

المصدر: Osteoarthritis and Cartilage ; volume 31, issue 6, page 727-740 ; ISSN 1063-4584

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biomedical Engineering, Rheumatology

الإتاحة: https://doi.org/10.1016/j.joca.2022.11.007Test
https://api.elsevier.com/content/article/PII:S1063458422009311?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1063458422009311?httpAccept=text/plainTest

المؤلفون: van der Laan, K.W.F., Reesink, K.D., van der Bruggen, M.M., Jaminon, A.M.G., Schurgers, L.J., Megens, R.T.A., Huberts, W., Delhaas, T., Spronck, B.

المصدر: van der Laan , K W F , Reesink , K D , van der Bruggen , M M , Jaminon , A M G , Schurgers , L J , Megens , R T A , Huberts , W , Delhaas , T & Spronck , B 2022 , ' Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy ' , Frontiers in physiology , vol. 12 , 814434 . https://doi.org/10.3389/fphys.2021.814434Test

مصطلحات موضوعية: cell content characterization, image analysis, nucleus segmentation, spectral clustering, cell density distribution, vascular smooth muscle cell apoptosis, APOPTOSIS, MECHANISMS

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/05914876-d5b8-4699-a4fa-0a7741d491e1Test

الإتاحة: https://doi.org/10.3389/fphys.2021.814434Test
https://cris.maastrichtuniversity.nl/en/publications/05914876-d5b8-4699-a4fa-0a7741d491e1Test

المؤلفون: van den Akker, G.G., Steijns, J.S., Stassen, R.H., Wasilewski, G.B., Wijnands, K.A., Schurgers, L.J., Caron, M.M., van Rhijn, L.W., Welting, T.J.

المصدر: Osteoarthritis and Cartilage ; volume 30, page S70-S71 ; ISSN 1063-4584

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biomedical Engineering, Rheumatology

الإتاحة: https://doi.org/10.1016/j.joca.2022.02.084Test
https://api.elsevier.com/content/article/PII:S1063458422001182?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1063458422001182?httpAccept=text/plainTest

المؤلفون: Akbulut, A.C., Wasilewski, G.B., Rapp, N., Forin, F., Singer, H., Czogalla-Nitsche, K.J., Schurgers, L.J.

المصدر: Akbulut , A C , Wasilewski , G B , Rapp , N , Forin , F , Singer , H , Czogalla-Nitsche , K J & Schurgers , L J 2021 , ' Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells ' , Frontiers in Cell and Developmental Biology , vol. 8 , 618760 . https://doi.org/10.3389/fcell.2020.618760Test

مصطلحات موضوعية: menaquinone-7, mesenchymal stem cells, osteogenesis, pluripotent stem cells, vitamin k

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/cbecacd7-752d-4a5e-ab17-34a1b4b1ac42Test

الإتاحة: https://doi.org/10.3389/fcell.2020.618760Test
https://cris.maastrichtuniversity.nl/en/publications/cbecacd7-752d-4a5e-ab17-34a1b4b1ac42Test

المؤلفون: Kaesler, N., Schurgers, L.J., Floege, J.

المصدر: Kaesler , N , Schurgers , L J & Floege , J 2021 , ' Vitamin K and cardiovascular complications in chronic kidney disease patients ' , Kidney International , vol. 100 , no. 5 , pp. 1023-1036 . https://doi.org/10.1016/j.kint.2021.06.037Test

مصطلحات موضوعية: calcification, cardiovascular disease, lipoproteins, matrix Gla protein, vitamin K, MATRIX GLA-PROTEIN, ORAL ANTICOAGULANT TREATMENT, GAMMA-CARBOXYGLUTAMIC ACID, CORONARY-HEART-DISEASE, VASCULAR CALCIFICATION, HEMODIALYSIS-PATIENTS, DIETARY-INTAKE, MENAQUINONE-7 SUPPLEMENTATION, DEPENDENT CARBOXYLATION, PLASMA PHYLLOQUINONE

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.kint.2021.06.037Test
https://cris.maastrichtuniversity.nl/en/publications/1b71c438-eead-40b3-b8c7-5d3cc785819cTest
https://cris.maastrichtuniversity.nl/ws/files/77859090/Schurgers_2021_Vitamin_K_and_cardiovascular_complications.pdfTest

المؤلفون: Rapp, N., Brandenburg, V.M., Kaesler, N., Bakker, S.J.L., Stohr, R., Schuh, A., Evenepoel, P., Schurgers, L.J.

المصدر: Rapp , N , Brandenburg , V M , Kaesler , N , Bakker , S J L , Stohr , R , Schuh , A , Evenepoel , P & Schurgers , L J 2021 , ' Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk ' , Nutrients , vol. 13 , no. 10 , 3490 . https://doi.org/10.3390/nu13103490Test

مصطلحات موضوعية: vitamin K, vitamin K dependent proteins, cardiovascular disease, dp-ucMGP, PIVKA-II, chronic kidney disease, calciphylaxis, MATRIX GLA-PROTEIN, HEMODIALYSIS-PATIENTS, DEPENDENT CARBOXYLATION, CALCIFICATION, SUPPLEMENTATION, CALCIUM, DEFICIENCY, EXPRESSION, PREVENTION

الإتاحة: https://doi.org/10.3390/nu13103490Test
https://cris.maastrichtuniversity.nl/en/publications/5e11f6cf-53a3-433d-9922-47ee674db3acTest

المؤلفون: Hariri, E., Kassis, N., Iskandar, J.P., Schurgers, L.J., Saad, A., Abdelfattah, O., Bansal, A., Isogai, T., Harb, S.C., Kapadia, S.

المصدر: Hariri , E , Kassis , N , Iskandar , J P , Schurgers , L J , Saad , A , Abdelfattah , O , Bansal , A , Isogai , T , Harb , S C & Kapadia , S 2021 , ' Vitamin K-2-a neglected player in cardiovascular health: a narrative review ' , Open Heart , vol. 8 , no. 2 , e001715 . https://doi.org/10.1136/openhrt-2021-001715Test

مصطلحات موضوعية: coronary vessels, atherosclerosis, heart valve diseases, pharmacology, clinical, biomarkers, MATRIX-GLA-PROTEIN, PHOSPHATE-INDUCED CALCIFICATION, GAMMA-CARBOXYGLUTAMIC ACID, CORONARY-ARTERY-DISEASE, K-DEPENDENT PROTECTION, CHRONIC KIDNEY-DISEASE, VASCULAR CALCIFICATION, MENAQUINONE-7 SUPPLEMENTATION, ANNULAR CALCIFICATION, HEMODIALYSIS-PATIENTS

الإتاحة: https://doi.org/10.1136/openhrt-2021-001715Test
https://cris.maastrichtuniversity.nl/en/publications/63a57381-ba58-4a3f-ba61-bb28aee9f2bcTest

المؤلفون: Jaminon, A.M.G., Akbulut, A.C., Rapp, N., Kramann, R., Biessen, E.A.L., Temmerman, L., Mees, B., Brandenburg, V., Dzhanaev, R., Jahnen-Dechent, W., Floege, J., Uitto, J., Reutelingsperger, C.P., Schurgers, L.J.

المصدر: Jaminon , A M G , Akbulut , A C , Rapp , N , Kramann , R , Biessen , E A L , Temmerman , L , Mees , B , Brandenburg , V , Dzhanaev , R , Jahnen-Dechent , W , Floege , J , Uitto , J , Reutelingsperger , C P & Schurgers , L J 2021 , ' Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity ' , Cells , vol. 10 , no. 8 , 2097 . https://doi.org/10.3390/cells10082097Test

مصطلحات موضوعية: vascular calcification, vascular smooth muscle cells, BioHybrid, fetuin-A, matrix Gla protein, vitamin K, vitamin K antagonist, cardiovascular disease, CORONARY-ARTERY CALCIFICATION, CHRONIC KIDNEY-DISEASE, ALL-CAUSE MORTALITY, CARDIOVASCULAR EVENTS, RENAL-DISEASE, CALCIUM, HEMODIALYSIS, PROGRESSION, SURVIVAL, RISK

الإتاحة: https://doi.org/10.3390/cells10082097Test
https://cris.maastrichtuniversity.nl/en/publications/990d81d0-ee14-4743-a23d-95b11b4c4167Test