المؤلفون: Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Sejberg, Jimmy, Honey, Mark A., Czodrowski, Paul, Stubbs, Mark, Poeschke, Oliver, Busch, Michael, Schneider, Richard, Schwartz, Daniel, Musil, Djordje, Burke, Rosemary, Urbahns, Klaus, Workman, Paul, Wienke, Dirk, Clarke, Paul A., Raynaud, Florence I., Eccles, Suzanne A., Esdar, Christina, Rohdich, Felix, Blagg, Julian

المصدر: 7 ; 6 ; 573 ; 578

مصطلحات موضوعية: CDK8, CDK19, mediator complex, kinase inhibitor, aldehyde oxidase

وصف الملف: application/PDF

العلاقة: Mallinger, A., Schiemann, K., Rink, C. Sejberg, J, Honey, M. A. et. al. (2014) 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19, ACS Medicinal Chemistry Letters, 7(6), pp. 573-578.; http://hdl.handle.net/2436/622516Test; ACS Medicinal Chemistry Letters

الإتاحة: https://doi.org/10.1021/acsmedchemlett.6b00022Test
http://hdl.handle.net/2436/622516Test

المؤلفون: Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I., Clarke, Paul A., Musil, Djordje, Schwarz, Daniel, Dale, Trevor Clive, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai

وصف الملف: application/pdf

العلاقة: https://orca.cardiff.ac.uk/id/eprint/96681/1/acs.jmedchem.6b00597.pdfTest; Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I., Clarke, Paul A., Musil, Djordje, Schwarz, Daniel, Dale, Trevor Clive https://orca.cardiff.ac.uk/view/cardiffauthors/A050728Q.htmlTest orcid:0000-0002-4880-9963 orcid:0000-0002-4880-9963, Urbahns, Klaus, Blagg, Julian and Schiemann, Kai 2016. Structure-based optimization of potent, selective, and orally bioavailable CDK8 inhibitors discovered by high-throughput screening. Journal of Medicinal Chemistry 59 (20) , pp. 9337-9349. 10.1021/acs.jmedchem.6b00597 https://doi.org/10.1021/acs.jmedchem.6b00597Test file https://orca.cardiff.ac.uk/id/eprint/96681/1/acs.jmedchem.6b00597.pdfTest

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b00597Test
https://orca.cardiff.ac.uk/id/eprint/96681Test/
https://orca.cardiff.ac.uk/id/eprint/96681/1/acs.jmedchem.6b00597.pdfTest

المؤلفون: Clarke, Paul A., Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stefanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phllip, Hobbs, Stephen M., Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C., Eccles, Suzanne A., Hecht, Stefan, Urbahns, Klaus, Workman, Paul, Wienke, Dirk

وصف الملف: application/pdf

العلاقة: https://orca.cardiff.ac.uk/id/eprint/96966/1/elife-20722-v3.pdfTest; Clarke, Paul A., Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stefanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken orcid:0000-0001-6622-9009 orcid:0000-0001-6622-9009, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phllip, Hobbs, Stephen M., Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C. https://orca.cardiff.ac.uk/view/cardiffauthors/A050728Q.htmlTest orcid:0000-0002-4880-9963 orcid:0000-0002-4880-9963, Eccles, Suzanne A., Hecht, Stefan, Urbahns, Klaus, Workman, Paul and Wienke, Dirk 2016. Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases. eLife 5 , e20722. 10.7554/eLife.20722 https://doi.org/10.7554/eLife.20722Test file https://orca.cardiff.ac.uk/id/eprint/96966/1/elife-20722-v3.pdfTest

الإتاحة: https://doi.org/10.7554/eLife.20722Test
https://orca.cardiff.ac.uk/id/eprint/96966Test/
https://orca.cardiff.ac.uk/id/eprint/96966/1/elife-20722-v3.pdfTest

المؤلفون: Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A., Esdar, Christina, Raynaud, Florence I., Eccles, Suzanne A., Rohdich, Felix, Blagg, Julian

المساهمون: Cancer Research UK, Royal Marsden NHS Foundation Trust

المصدر: Journal of Medicinal Chemistry ; volume 59, issue 3, page 1078-1101 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.5b01685Test

المؤلفون: Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T., Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A., Eccles, Suzanne A., Stieber, Frank, Schiemann, Kai, Blagg, Julian

المساهمون: Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 58, issue 4, page 1717-1735 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/jm501436mTest