المؤلفون: Lee, Joyce V, Housley, Filomena, Yau, Christina, Nakagawa, Rachel, Winkler, Juliane, Anttila, Johanna M, Munne, Pauliina M, Savelius, Mariel, Houlahan, Kathleen E, Van de Mark, Daniel, Hemmati, Golzar, Hernandez, Grace A, Zhang, Yibing, Samson, Susan, Baas, Carole, Kok, Marleen, Esserman, Laura J, van ‘t Veer, Laura J, Rugo, Hope S, Curtis, Christina, Klefström, Juha, Matloubian, Mehrdad, Goga, Andrei

المصدر: Nature Communications. 13(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Vaccine Related, Cancer, Breast Cancer, Immunization, Animals, B7-H1 Antigen, Humans, Immune Checkpoint Inhibitors, Immune Evasion, Immunotherapy, Mice, Proto-Oncogene Proteins c-myc, Signal Transduction, Triple Negative Breast Neoplasms

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0d40s5d3Test

المؤلفون: Joyce V. Lee, Filomena Housley, Christina Yau, Rachel Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina M. Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark, Golzar Hemmati, Grace A. Hernandez, Yibing Zhang, Susan Samson, Carole Baas, Laura J. Esserman, Laura J. van ‘t Veer, Hope S. Rugo, Christina Curtis, Juha Klefström, Mehrdad Matloubian, Andrei Goga

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/5ba305a5a1f9497c9247af3f00c75befTest

المؤلفون: Nordling, Esa, Kivistö, Mari, Martin, Marjatta, Rissanen , Päivi, Savelius-Koski, Eija, Soronen, Kari

المساهمون: Martin, Marjatta, Soronen, Kari

المصدر: Nordling , E , Kivistö , M , Martin , M , Rissanen , P , Savelius-Koski , E & Soronen , K 2022 , Mielenterveys- ja päihdepalvelujen asiakaslähtöisyys terveydenhuollon järjestämissuunnitelmissa . julkaisussa M Martin & K Soronen (toim) , Toipumisorientaatio mielenterveyspalveluissa . Lapin yliopisto , Lapin yliopiston yhteiskuntatieteellisiä julkaisuja. Sarja C. Työpapereita , Nro 8 , Sivut 123-139 . < https://urn.fi/URN:ISBN:978-952-337-321-1Test >

مصطلحات موضوعية: /dk/atira/pure/person/fieldofscience2010/5/14/6, Kuntoutus, /dk/atira/pure/person/fieldofscience2010/5/14/5, Sosiaalityö

الإتاحة: https://research.ulapland.fi/fi/publications/1930b4f8-c2ea-4106-a2e0-df05663a10f5Test
https://urn.fi/URN:ISBN:978-952-337-321-1Test

المؤلفون: Joyce V. Lee, Filomena Housley, Christina Yau, Rachel Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina M. Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark, Golzar Hemmati, Grace A. Hernandez, Yibing Zhang, Susan Samson, Carole Baas, Marleen Kok, Laura J. Esserman, Laura J. van ‘t Veer, Hope S. Rugo, Christina Curtis, Juha Klefström, Mehrdad Matloubian, Andrei Goga

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/c4c95fa626f54c138a7df8b82c363e2cTest

المؤلفون: Lee, Joyce, Housley, Filomena, Yau, Christina, Nakagawa, Rachel, Winkler, Juliane, Anttila, Johanna M., Munne, Pauliina M., Savelius, Mariel, Houlahan, Kathleen E., Van de Mark, Daniel, Hemmati, Golzar, Hernandez, Grace A., Zhang, Yibing, Samson, Susan, Baas, Carole, Esserman, Laura J., van 't Veer, Laura J., Rugo, Hope S., Curtis, Christina, Klefström, Juha, Matloubian, Mehrdad, Goga, Andrei

المساهمون: CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, HUS Comprehensive Cancer Center

مصطلحات موضوعية: COMPREHENSIVE MOLECULAR PORTRAITS, CLASS-I, ACQUIRED-RESISTANCE, GENE-EXPRESSION, ONCOGENE, PD-L1, MUTATIONS, TUMORS, IDENTIFICATION, ACTIVATION, Cancers

وصف الملف: application/pdf

العلاقة: This work was supported by the US National Institutes of Health 1R01CA223817 (A.G.), F32CA243548 (J.V.L.), T32CA108462 (to J.V.L.); the CDMRP Breast Cancer Research Program W81XWH-16-1-0603 (A.G.) and W81XWH-21-1-0774 (A.G., J.K.); the Breast Cancer Research Foundation (H.S.R.); METAvivor Research Award (A.G.); The Mark Foundation Endeavor Awards (A.G.); The Gazarian Family Endowment (A.G.) and the National Science Foundation #1650113 (to R.N.). We acknowledge the PFCC (RRID:SCR_018206) for assistance generating flow cytometry data. Research reported here was supported in part by the DRC Center Grant NIH P30 DK063720. We thank all of the patients who volunteered to participate in the I-SPY 2 TRIAL.; Lee , J , Housley , F , Yau , C , Nakagawa , R , Winkler , J , Anttila , J M , Munne , P M , Savelius , M , Houlahan , K E , Van de Mark , D , Hemmati , G , Hernandez , G A , Zhang , Y , Samson , S , Baas , C , Esserman , L J , van 't Veer , L J , Rugo , H S , Curtis , C , Klefström , J , Matloubian , M & Goga , A 2022 , ' Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer ' , Nature Communications , vol. 13 , no. 1 , 3671 . https://doi.org/10.1038/s41467-022-31238-yTest; ORCID: /0000-0002-9720-9964/work/156645869; http://hdl.handle.net/10138/346480Test; f07047aa-7774-4b3d-9e9b-95717a63619d; 000818961600008

الإتاحة: http://hdl.handle.net/10138/346480Test

المؤلفون: Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/d3f1f919795e44fe8702e5ba84a712b6Test

المؤلفون: Haikala, Heidi M., Anttila, Johanna M., Marques, Elsa, Raatikainen, Tiina, Ilander, Mette, Hakanen, Henna, Ala-Hongisto, Hanna, Savelius, Mariel, Balboa, Diego, Von Eyss, Bjoern, Eskelinen, Vilja, Munne, Pauliina, Nieminen, Anni I., Otonkoski, Timo, Schüler, Julia, Laajala, Teemu D., Aittokallio, Tero, Sihto, Harri, Mattson, Johanna, Heikkilä, Päivi, Leidenius, Marjut, Joensuu, Heikki, Mustjoki, Satu, Kovanen, Panu, Eilers, Martin, Leverson, Joel D., Klefström, Juha

المساهمون: Translational Cancer Biology (TCB) Research Programme, Research Programs Unit, University of Helsinki, Medicum, CAN-PRO - Translational Cancer Medicine Program, Integrins in immunity, Department of Clinical Chemistry and Hematology, Clinicum, Department of Oncology, Centre of Excellence in Stem Cell Metabolism, Timo Pyry Juhani Otonkoski / Principal Investigator, Research Programme for Molecular Neurology, Juha Klefström / Principal Investigator, Biosciences, Institute of Biotechnology, STEMM - Stem Cells and Metabolism Research Program, Institute for Molecular Medicine Finland, Tero Aittokallio / Principal Investigator, Department of Pathology, II kirurgian klinikka, Department of Surgery, Heikki Joensuu / Principal Investigator, Hematologian yksikkö, HUSLAB, HUS Children and Adolescents, HUS Comprehensive Cancer Center

مصطلحات موضوعية: IN-VIVO EFFICACY, C-MYC, GENE-EXPRESSION, BREAST-CANCER, METFORMIN, ACTIVATION, MECHANISMS, ABT-737, BCL-2, BIM, 3111 Biomedicine, 3122 Cancers

وصف الملف: application/pdf

العلاقة: We thank Biomedicum Functional Genomics Unit (FuGu), Biomedicum Imaging Unit (BIU), University of Helsinki Language services, and Biomedicum FACS Core for services, Tarja Valimaki and Maiju Merisalo-Soikkeli for technical support, Prof. Kari Alitalo and Pauliina Kallio (University of Helsinki) for providing advice and reagents for mouse experiments, Anne Lehtonen (AbbVie Oy) for commenting the manuscript, and Johanna Englund for help with the experiments. This work was funded by the Academy of Finland, TEKES and the Finnish Cancer Organizations; H.M.H. was funded by the Integrative Life Sciences Doctoral Program (ILS), DSHealth doctoral school, Biomedicum Helsinki Foundation, Orion-Farmos Foundation, Emil Aaltonen Foundation, and the Inkeri & Mauri Vanska Foundation. S.M. and M.I. were funded by the Finnish Cancer Institute, Sigrid Juselius Foundation, Finnish special governmental subsidy for health sciences, research, and training (EVO-funding).; Haikala , H M , Anttila , J M , Marques , E , Raatikainen , T , Ilander , M , Hakanen , H , Ala-Hongisto , H , Savelius , M , Balboa , D , Von Eyss , B , Eskelinen , V , Munne , P , Nieminen , A I , Otonkoski , T , Schüler , J , Laajala , T D , Aittokallio , T , Sihto , H , Mattson , J , Heikkilä , P , Leidenius , M , Joensuu , H , Mustjoki , S , Kovanen , P , Eilers , M , Leverson , J D & Klefström , J 2019 , ' Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy ' , Nature Communications , vol. 10 , 620 . https://doi.org/10.1038/s41467-019-08541-2Test; ORCID: /0000-0003-0281-2507/work/55348826; ORCID: /0000-0002-0886-9769/work/55352310; ORCID: /0000-0002-0816-8241/work/55353373; ORCID: /0000-0003-0249-3374/work/63350527; ORCID: /0000-0001-5265-5509/work/116550031; ORCID: /0000-0001-8999-6040/work/147391055; ORCID: /0000-0002-9720-9964/work/156645864; http://hdl.handle.net/10138/300047Test; 8a475917-513b-45d5-bcfd-f32c4654305d; 85061155012; 000457862200005

الإتاحة: http://hdl.handle.net/10138/300047Test

المؤلفون: Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

مصطلحات موضوعية: Science

العلاقة: https://doi.org/10.1038/s41467-019-08956-xTest; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/be938228d9c14a09b1d43012150cc2cdTest

الإتاحة: https://doi.org/10.1038/s41467-019-08956-xTest
https://doaj.org/article/be938228d9c14a09b1d43012150cc2cdTest

المؤلفون: Haikala, Heidi M., Anttila, Johanna M., Marques, Elsa, Raatikainen, Tiina, Ilander, Mette, Hakanen, Henna, Ala-Hongisto, Hanna, Savelius, Mariel, Balboa, Diego, Von Eyss, Bjoern, Eskelinen, Vilja, Munne, Pauliina, Nieminen, Anni I., Otonkoski, Timo, Schüler, Julia, Laajala, Teemu D., Aittokallio, Tero, Sihto, Harri, Mattson, Johanna, Heikkilä, Päivi, Leidenius, Marjut, Joensuu, Heikki, Mustjoki, Satu, Kovanen, Panu, Eilers, Martin, Leverson, Joel D., Klefström, Juha

المصدر: Nature Communications ; volume 10, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41467-019-08956-xTest
https://www.nature.com/articles/s41467-019-08956-x.pdfTest
https://www.nature.com/articles/s41467-019-08956-xTest

المؤلفون: Greenlees, PT, Amzal, N, Butler, PA, Cann, KJ, Cocks, JFC, Hawcroft, D, Jones, GD, Page, RD, Andreev, A, Enqvists, T, Fallon, P, Gall, B, Guttormsen, M, Helariutta, K, Hessberger, PP, Hoellinger, F, Jones, P, Julin, R, Juutinen, S, Kankaanpää, H, Kettunen, H, Kuusiniemi, P, Leino, M, Messelt, S, Muikku, M, Savelius, A, Schiller, A, Siem, S, Trzaska, WH, Tveter, T, Uusitalo, J

المصدر: Acta Physica Polonica B. 30(3)

مصطلحات موضوعية: Nuclear & Particles Physics, Mathematical Sciences, Physical Sciences

الوصول الحر: https://escholarship.org/uc/item/5m30b33zTest