Simultaneous inhibition of PD-1 and LAG-3: the future of immunotherapy?
| العنوان: | Simultaneous inhibition of PD-1 and LAG-3: the future of immunotherapy? |
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| المؤلفون: | Sasha-Jane Abi-Aad, Joseph Zouein, Antoine Chartouni, Nabih Naim, Hampig Raphael Kourie |
| المصدر: | Immunotherapy. 15:611-618 |
| بيانات النشر: | Future Medicine Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Oncology, Immunology, Immunology and Allergy |
| الوصف: | Immunotherapy has improved the prognosis of many cancers, yet a large number of patients have demonstrated resistance to current immune checkpoint inhibitors. LAG-3 is an immune checkpoint expressed on tumor-infiltrating lymphocytes CD4+ and CD8+, Tregs and other immune cells. Coexpression of PD-1 and LAG-3 in solid or hematological cancers is generally associated with a poor prognosis and may be responsible for immunotherapy resistance. Dual inhibition therapy in the RELATIVITY-047 trial significantly improved progression-free survival in metastatic melanoma. This article discusses the presence of a possible synergistic interaction between LAG-3 and PD-1 in the tumor microenvironment and the utility of targeting both immune checkpoint inhibitors as an effective way to bypass resistance and increase treatment efficacy. |
| تدمد: | 1750-7448 1750-743X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::10839ca5231ffd0e04f64701fcee500dTest https://doi.org/10.2217/imt-2022-0185Test |
| رقم الانضمام: | edsair.doi...........10839ca5231ffd0e04f64701fcee500d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17507448 1750743X |
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