دورية
Abstract 11957: Lipid Transfer to High Density Lipoproteins is Impaired and Cholesteryl Ester Transfer Protein Plasma Concentration is Diminished in Patients With Peripheral Arterial Disease
| العنوان: | Abstract 11957: Lipid Transfer to High Density Lipoproteins is Impaired and Cholesteryl Ester Transfer Protein Plasma Concentration is Diminished in Patients With Peripheral Arterial Disease |
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| المؤلفون: | Lopes, Natalia M, Ribeiro, Fl?vio R, Azevedo, Carolina H, Tavoni, Thauany M, Sarges, Erica S, Freitas, Fatima R, Albuquerque, Camila, Kalil, Roberto, Maranhao, Raul C |
| المصدر: | Circulation (Ovid); November 2019, Vol. 140 Issue: Supplement 1 pA11957-A11957, 1p |
| مستخلص: | Introduction:Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis, associated with higher risks of coronary artery disease. PAD is characterized by diminished HDL-C levels and a less frequent increase in the LDL-C and triglycerides levels. Although the HDL-C levels is one of the most important predictors of cardiovascular disease, the evaluation of the HDL functional aspects may add much more to the overall comprehension of the HDL impact on atherogenesis. In this context, lipid transfer from other lipoprotein classes to HDL are important players in the metabolism and function of this lipoprotein.Hypothesis:To examine the lipid transfers to HDL and the causes of the HDL diminishment in PAD is very important to prevent the disease and to develop new therapeutic targets.Methods:Patients with PAD (n=29, 69?11 yrs, 19 men) and volunteers without PAD (n=21, 68?7 yrs, 11 men) were enrolled. Lipid transfer was performed by incubating plasma with a donor nanoparticle containing radioactivity unesterified (UC) and esterified-cholesterol (EC), phospholipids (PL) and triglycerides (TG), followed by chemical precipitation and radioactive count.Results:PAD patients had lower HDL-C (40?11 vs 50?15 mg/dL; p<0.01) than controls. LDL-C and triglycerides levels were unchanged. Transfers of UC (4.82?1.37 vs 6.60?1.25%; p<0.001), EC (3.35?1.06 vs 4.12?0.89%; p<0.01), and TG (4.22?0.59 vs 5.66?1.05%; p<0.001) were lower in PAD patients, and transfer of PL was unchanged. PAD patients had lower CETP (1.18?0.80 vs 1.63?0.70 ?g/mL; p<0.05). LCAT did not differ in the two groups.Conclusions:Among the classical lipid risk factors, low HDL-C was the actual marker of PAD, since LDL-C and triglycerides were not different from the controls. Both transfers to HDL of UC and EC were decreased in PAD, as compared to controls, together with lower concentration of CETP, the protein that facilitates the lipid transfers. This indicates that the HDL metabolism is disturbed in PAD, possibly affecting the reverse cholesterol transport that largely depends on those lipid fluxes. Also, the results suggest that the capacity of HDL for cholesterol esterification is hampered in PAD due to diminished UC transfer to the lipoprotein, despite normal LCAT levels. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00097322 15244539 |
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| DOI: | 10.1161/circ.140.suppl_1.11957 |