دورية أكاديمية
One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients
| العنوان: | One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients |
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| المؤلفون: | Piñana, Jose Luis, Vazquez, Lourdes, Calabuig, Marisa, López-Corral, Lucia, Martin Martin, Gabriel Andrés, Villalon, Lucia, Sanz-Linares, Gabriel, Conesa-Garcia, Venancio, Sanchez-Salinas, Andrés, Gago, Beatriz, Facal, Ana, Risco Gálvez, Irene, Olave, Maria T., Espigado, Ildefonso, Lopez-Jimenez, Javier, Hernández-Rivas, Jose Ángel, Avendaño-Pita, Alejandro, Arroyo, Ignacio, Ferrer, Elena, García-Cadenas, Irene, González-Santillana, Clara, Roldán-Pérez, Alicia, Ferrer, Blanca, Guerreiro, Manuel, Suarez-Lledó, Maria, Camara, Angela, Campos-Beltrán, Diana, Navarro, David, Cedillo, Ángel, Sureda, Anna, Solano Vercet, Carlos, Spanish Hematopoietic Stem Cell Transplantation Ce, Martino, Rodrigo |
| سنة النشر: | 2023 |
| المجموعة: | Universitat de València: Roderic - Repositorio de contenido libre |
| مصطلحات موضوعية: | Malalties transmissibles |
| الوصف: | The long-term clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has been little explored. A prospective multicenter registry-based cohort study conducted from December 2020 to July 2022 by the Spanish Transplant and Cell Therapy group, was used to analyze the relationship of antibody response over time after full vaccination (at 3-6 weeks, 3, 6 and 12 months) (2 doses) and of booster doses with breakthrough SARS-CoV-2 infection in 1551 patients with hematological disorders. At a median follow-up of 388 days after complete immunization, 266 out of 1551 (17%) developed breakthrough SARS-CoV-2 infection at median of 86 days (range 7-391) after full vaccination. The cumulative incidence was 18% [95% confidence interval (C.I.), 16-20%]. Multivariate analysis identified higher incidence in chronic lymphocytic leukemia patients (29%) and with the use of corticosteroids (24.5%), whereas female sex (15.5%) and more than 1 year after last therapy (14%) were associated with a lower incidence (p < 0.05 for all comparisons). Median antibody titers at different time points were significantly lower in breakthrough cases than in non-cases. A serological titer cut-off of 250 BAU/mL was predictive of breakthrough infection and its severity. SARS-CoV-2 infection-related mortality was encouragingly low (1.9%) in our series. Our study describes the incidence of and risk factors for COVID-19 breakthrough infections during the initial vaccination and booster doses in the 2021 to mid-2022 period. The level of antibody titers at any time after 2-dose vaccination is strongly linked with protection against both breakthrough infection and severe disease, even with the Omicron SARS-CoV-2 variant. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Blood Cancer Journal, 2023, vol. 13, num. 1; Piñana, Jose Luis Vazquez, Lourdes Calabuig, Marisa López-Corral, Lucia Martin Martin, Gabriel Andrés Villalon, Lucia Sanz-Linares, Gabriel Conesa-Garcia, Venancio Sanchez-Salinas, Andrés Gago, Beatriz Facal, Ana Risco Gálvez, Irene Olave, Maria T. Espigado, Ildefonso Lopez-Jimenez, Javier Hernández-Rivas, Jose Ángel Avendaño-Pita, Alejandro Arroyo, Ignacio Ferrer, Elena García-Cadenas, Irene González-Santillana, Clara Roldán-Pérez, Alicia Ferrer, Blanca Guerreiro, Manuel Suarez-Lledó, Maria Camara, Angela Campos-Beltrán, Diana Navarro, David Cedillo, Ángel Sureda, Anna Solano Vercet, Carlos Spanish Hematopoietic Stem Cell Transplantation Ce Martino, Rodrigo 2023 One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients Blood Cancer Journal 13 1; https://hdl.handle.net/10550/84914Test; 156239 |
| DOI: | 10.1038/s41408-022-00778-3 |
| الإتاحة: | https://doi.org/10.1038/s41408-022-00778-3Test https://hdl.handle.net/10550/84914Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.7D647D21 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41408-022-00778-3 |
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