المؤلفون: Lawrence, Rosalie, Shoemaker, Sophie, Deal, Aniliese, Sangwan, Smriti, Anand, Aditya, Wang, Lan, Walter, Peter, Marqusee, Susan

المصدر: Nature Chemical Biology. 20(4)

مصطلحات موضوعية: Eukaryotic Initiation Factor-2B, Allosteric Regulation, Cryoelectron Microscopy, Guanine Nucleotide Exchange Factors, Signal Transduction, Phosphorylation

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1tm3k65rTest

المؤلفون: Azumaya, Caleigh M, Braxton, Julian R, Brilot, Axel F, Gupta, Meghna, Li, Fei, Lopez, Kyle E, Melo, Arthur, Merz, Gregory E, Moss, Frank, Paulino, Joana, Pospiech, Thomas H, Pourmal, Sergei, Puchades, Cristina, Rizo, Alexandrea N, Smith, Amber M, Sun, Ming, Thomas, Paul V, Wang, Feng, Yu, Zanlin, Asarnow, Daniel, Campbell, Melody G, Chio, Cynthia M, Chio, Un Seng, Dickinson, Miles Sasha, Diwanji, Devan, Faust, Bryan, Hoppe, Nick, Jin, Mingliang, Li, Junrui, Liu, Yanxin, Nguyen, Henry C, Sangwan, Smriti, Trenker, Raphael, Trinidad, Donovan, Tse, Eric, Zhang, Kaihua, Zhou, Fengbo, Billesboelle, Christian, Bowen, Alisa, Li, Yen-Li, Nguyen, Phuong, Nowotny, Carlos, Safari, Mali, Schaefer, Kaitlin, Tsui, Tsz Kin Martin, Whitis, Natalie, Zhao, Jianhua, Kim, Kate, Moritz, Michelle, Owens, Tristan W, Peters, Jessica K, Biel, Justin, Deshpande, Ishan, Herrera, Nadia, Kratochvil, Huong T, Liu, Xi, Schulze-Gahmen, Ursula, Young, Iris D, Chen, Jen, Diallo, Amy, Doan, Loan, Flores, Sebastian, Lam, Victor L, Li, Yang, Lo, Megan, Thwin, Aye C, Titus, Erron W, Zhang, Yang, Bulkley, David

المصدر: Nature Chemical Biology. 17(1)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Biodefense, Vaccine Related, Clinical Research, Prevention, Lung, Emerging Infectious Diseases, Infectious Diseases, Pneumonia & Influenza, Pneumonia, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Animals, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Antibody, Chlorocebus aethiops, Cryoelectron Microscopy, HEK293 Cells, Humans, Models, Molecular, Peptide Library, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, SARS-CoV-2, Single-Chain Antibodies, Spike Glycoprotein, Coronavirus, Vero Cells, QCRG Structural Biology Consortium, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8zr984wfTest

المؤلفون: Schoof, Michael, Faust, Bryan, Saunders, Reuben A, Sangwan, Smriti, Rezelj, Veronica, Hoppe, Nick, Boone, Morgane, Billesbølle, Christian B, Puchades, Cristina, Azumaya, Caleigh M, Kratochvil, Huong T, Zimanyi, Marcell, Deshpande, Ishan, Liang, Jiahao, Dickinson, Sasha, Nguyen, Henry C, Chio, Cynthia M, Merz, Gregory E, Thompson, Michael C, Diwanji, Devan, Schaefer, Kaitlin, Anand, Aditya A, Dobzinski, Niv, Zha, Beth Shoshana, Simoneau, Camille R, Leon, Kristoffer, White, Kris M, Chio, Un Seng, Gupta, Meghna, Jin, Mingliang, Li, Fei, Liu, Yanxin, Zhang, Kaihua, Bulkley, David, Sun, Ming, Smith, Amber M, Rizo, Alexandrea N, Moss, Frank, Brilot, Axel F, Pourmal, Sergei, Trenker, Raphael, Pospiech, Thomas, Gupta, Sayan, Barsi-Rhyne, Benjamin, Belyy, Vladislav, Barile-Hill, Andrew W, Nock, Silke, Liu, Yuwei, Krogan, Nevan J, Ralston, Corie Y, Swaney, Danielle L, García-Sastre, Adolfo, Ott, Melanie, Vignuzzi, Marco, Walter, Peter, Manglik, Aashish, Braxton, Julian R, Lopez, Kyle E, Melo, Arthur, Paulino, Joana, Pospiech, Thomas H, Thomas, Paul V, Wang, Feng, Yu, Zanlin, Dickinson, Miles Sasha, Asarnow, Daniel, Campbell, Melody G, Li, Junrui, Tsui, Tsz Kin Martin, Trinidad, Donovan, Tse, Eric, Zhou, Fengbo, Herrera, Nadia, Schulze-Gahmen, Ursula

المصدر: Science. 370(6523)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Lung, Vaccine Related, Prevention, Infectious Diseases, Pneumonia, Pneumonia & Influenza, Biodefense, Emerging Infectious Diseases, Angiotensin-Converting Enzyme 2, Animals, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Chlorocebus aethiops, Cryoelectron Microscopy, Humans, Neutralization Tests, Protein Binding, Protein Stability, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus, Vero Cells, QCRG Structural Biology Consortium, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1ks1d323Test
https://escholarship.org/content/qt1ks1d323/qt1ks1d323.pdfTest

المؤلفون: Sangwan, Smriti, Sahay, Shruti, Murray, Kevin A, Morgan, Sophie, Guenther, Elizabeth L, Jiang, Lin, Williams, Christopher K, Vinters, Harry V, Goedert, Michel, Eisenberg, David S

مصطلحات موضوعية: Humans, Parkinson Disease, alpha-Synuclein, HEK293 Cells, Protein Aggregates, Protein Aggregation, Pathological, Parkinson's disease, alpha-synuclein, biochemistry, chemical biology, human, inhibitor design, seeding, Neurosciences, Neurodegenerative, Aging, Dementia, Brain Disorders, Acquired Cognitive Impairment, Prevention, Parkinson's Disease, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Neurological, Biochemistry and Cell Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7mq2t05xTest

المؤلفون: Lawrence, Rosalie E., Shoemaker, Sophie R., Deal, Aniliese, Sangwan, Smriti, Anand, Aditya A., Wang, Lan, Marqusee, Susan, Walter, Peter

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences, Jane Coffin Childs Memorial Fund for Medical Research, Jane Coffin Childs/Howard Hughes Medical Institute Postdoctoral Fellowship, Helen Hay Whitney Foundation Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute, Calico Life Sciences LLC George and Judy Marcus Family Foundation

المصدر: Nature Chemical Biology ; ISSN 1552-4450 1552-4469

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1038/s41589-023-01453-9Test
https://www.nature.com/articles/s41589-023-01453-9.pdfTest
https://www.nature.com/articles/s41589-023-01453-9Test

المؤلفون: D., Thanh, Sangwan, Smriti, de Almeida, Natália EC, Ilitchev, Alexandre I, Giammona, Maxwell, Sawaya, Michael R, Buratto, Steven K, Eisenberg, David S, Bowers, Michael T

المصدر: Protein Science. 27(7)

مصطلحات موضوعية: Analytical Chemistry, Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease, Dementia, Acquired Cognitive Impairment, Aging, Neurodegenerative, Brain Disorders, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Neurological, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Peptides, Crystallography, X-Ray, Humans, Magnetic Resonance Spectroscopy, Microscopy, Atomic Force, Models, Molecular, Mutation, Protein Structure, Secondary, amyloid, aggregation, co-assembly, ion-mobility mass spectrometry, X-ray crystallography, Computation Theory and Mathematics, Other Information and Computing Sciences, Biophysics, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3590w44jTest

المؤلفون: Sangwan, Smriti, Zhao, Anni, Adams, Katrina L, Jayson, Christina K, Sawaya, Michael R, Guenther, Elizabeth L, Pan, Albert C, Ngo, Jennifer, Moore, Destaye M, Soriaga, Angela B, D., Thanh, Goldschmidt, Lukasz, Nelson, Rebecca, Bowers, Michael T, Koehler, Carla M, Shaw, David E, Novitch, Bennett G, Eisenberg, David S

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(33)

مصطلحات موضوعية: ALS, Rare Diseases, Neurodegenerative, Brain Disorders, Neurosciences, Neurological, Amyotrophic Lateral Sclerosis, Animals, Crystallography, X-Ray, Mice, Motor Neurons, Mutation, Protein Conformation, beta-Strand, Superoxide Dismutase-1, oligomer, SOD1

الوصول الحر: https://escholarship.org/uc/item/93n8t49zTest

المؤلفون: Rodriguez, Jose A, Ivanova, Magdalena I, Sawaya, Michael R, Cascio, Duilio, Reyes, Francis E, Shi, Dan, Sangwan, Smriti, Guenther, Elizabeth L, Johnson, Lisa M, Zhang, Meng, Jiang, Lin, Arbing, Mark A, Nannenga, Brent L, Hattne, Johan, Whitelegge, Julian, Brewster, Aaron S, Messerschmidt, Marc, Boutet, Sébastien, Sauter, Nicholas K, Gonen, Tamir, Eisenberg, David S

المصدر: Nature. 525(7570)

مصطلحات موضوعية: Lewy Bodies, Humans, Parkinson Disease, Amyloid, Cryoelectron Microscopy, Protein Structure, Tertiary, Electrons, Scattering, Radiation, Models, Molecular, alpha-Synuclein, Nanoparticles, Acquired Cognitive Impairment, Dementia, Parkinson's Disease, Neurosciences, Neurodegenerative, Brain Disorders, General Science & Technology

الوصول الحر: https://escholarship.org/uc/item/7760k1zbTest

المؤلفون: D., Thanh, LaPointe, Nichole E, Sangwan, Smriti, Teplow, David B, Feinstein, Stuart C, Sawaya, Michael R, Eisenberg, David S, Bowers, Michael T

المصدر: The Journal of Physical Chemistry B. 118(26)

مصطلحات موضوعية: Alzheimer's Disease, Brain Disorders, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Aging, Dementia, Amino Acid Sequence, Amyloid, Crystallography, X-Ray, Enkephalins, Mass Spectrometry, Microscopy, Electron, Transmission, Molecular Dynamics Simulation, Nanostructures, Protein Structure, Secondary, Protein Structure, Tertiary, Physical Sciences, Chemical Sciences, Engineering

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/208864zkTest

المؤلفون: Do, Thanh D, LaPointe, Nichole E, Sangwan, Smriti, Teplow, David B, Feinstein, Stuart C, Sawaya, Michael R, Eisenberg, David S, Bowers, Michael T

المصدر: The journal of physical chemistry. B. 118(26)

مصطلحات موضوعية: Amyloid, Enkephalins, Microscopy, Electron, Transmission, Crystallography, X-Ray, Amino Acid Sequence, Protein Structure, Secondary, Protein Structure, Tertiary, Nanostructures, Mass Spectrometry, Molecular Dynamics Simulation, Chemical Sciences, Engineering, Physical Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/208864zkTest