دورية أكاديمية
Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms
| العنوان: | Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms |
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| المؤلفون: | Bozena Smolkova, Agapi Kataki, Julie Earl, Ignacio Ruz-Caracuel, Marina Cihova, Maria Urbanova, Verona Buocikova, Sandra Tamargo, Vita Rovite, Helvijs Niedra, Joerg Schrader, Yvonne Kohl |
| سنة النشر: | 2022 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Pancreatic neuroendocrine neoplasms, Liquid biopsy, Circulating tumor cells, Circulating tumor DNA, Exosomes, Micro RNA, Preclinical models |
| الوصف: | Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for their management. The main clinical obstacles are the high rate of patients diagnosed at advanced stages, lack of prognostic markers for early detection of disease recurrence in resected patients, significant limitations in identifying those who will benefit from adjuvant therapy, and timely recognition of treatment response. Therefore, the discovery of new prognostic and predictive markers is necessary for patient stratification and clinical management. Liquid biopsy, which has revolutionized the field of clinical oncology, is extremely under-investigated in pNENs. This review highlights its potential and the recent advances in related technologies, as candidates for the delivery of the new tools that can help to refine pNEN diagnosis and to personalize treatment. In addition, the opportunities and limitations of available preclinical research models with regard to biomarker research are discussed in light of pNEN clinical needs. ; The authors acknowledge the Latvian Biomedical Research and Study Centre as well as the Genome Database of the Latvian Population for providing infrastructure and support. This research has received funding from the TRANSCAN-2 program ERA-NET JTC 2017 "Translational research on rare cancers" within the project NExT (Federal Ministry of Education and Research, Germany/ 01KT1910; Slovak Academy of Sciences, Slovakia/ NExT-0711; The Foundation for the support of the Applied Scientific Research and Technology in Asturias, Spain/ IDI/2019/000002; Ministry of Education, Research and Religious Affairs - General Secretariat for Research and Technology, Greece/ Τ9ЕРА3-00012; State Education Development Agency, Latvia/ 1.1.1.5/ ERANET/20/03) and from the European Union's Horizon 2020 research and innovation program under grant agreement No 857381 / VISION, the Spanish Biomedical Research Network in Cancer CIBERONC (CB16/12/00446) and from the Slovak Research and Development Agency (APVV-21-0197, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/grantAgreement/EC/H2020/857381/; https://zenodo.org/communities/vision-h2020Test; https://zenodo.org/record/7621338Test; https://doi.org/10.1016/j.critrevonc.2022.103865Test; oai:zenodo.org:7621338 |
| DOI: | 10.1016/j.critrevonc.2022.103865 |
| الإتاحة: | https://doi.org/10.1016/j.critrevonc.2022.103865Test https://zenodo.org/record/7621338Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.86868C2B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.critrevonc.2022.103865 |
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