نتائج البحث - "Sandra Olthof"

1

The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation

المؤلفون: Albertina Ausema, Martha Ritsema, Gerald de Haan, Leonid Bystrykh, Ronald van Os, Sandra Olthof, Gerwin Huls, Vincent van den Boom, Marta A. Walasek

المساهمون: Faculteit Medische Wetenschappen/UMCG, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)

المصدر: Blood
Blood, 119(13), 3050-3059. AMER SOC HEMATOLOGY
Blood; Vol 119
Blood, 119, 13, pp. 3050-9
Blood, 119, 3050-9

مصطلحات موضوعية: CHROMATIN, Time Factors, Immunology, FATE, Drug Evaluation, Preclinical, Biology, Cell fate determination, Lithium, Granulocyte-Macrophage Progenitor Cells, Biochemistry, Cell therapy, 03 medical and health sciences, Mice, 0302 clinical medicine, Translational research [ONCOL 3], Animals, Drug Interactions, Myeloid Cells, Progenitor cell, PLURIPOTENT, Cells, Cultured, 030304 developmental biology, Progenitor, 0303 health sciences, Valproic Acid, PROLIFERATION, Cell Differentiation, IN-VITRO, EXPANSION, Cell Biology, Hematology, Hematopoietic Stem Cells, GENE, Cell biology, Hematopoiesis, Endothelial stem cell, Mice, Inbred C57BL, SELF-RENEWAL, Haematopoiesis, Drug Combinations, Phenotype, 030220 oncology & carcinogenesis, lipids (amino acids, peptides, and proteins), Female, TRANSCRIPTION FACTOR GATA-2, Stem cell, STEM-CELLS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2110809ca5565f0eb445bbdab7ef1b2Test

2

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

المؤلفون: Gerald de Haan, Jaring Schreuder, Brad Dykstra, Sandra Olthof, Martha Ritsema

المساهمون: Faculteit Medische Wetenschappen/UMCG, Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2691-2703. ROCKEFELLER UNIV PRESS

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb829aff3d3044db1f056ba9f2419bTest
https://doi.org/10.1084/jem.20111490Test

3

Auto-SCT induces a phenotypic shift from CMP to GMP progenitors, reduces clonogenic potential and enhances in vitro and in vivo cycling activity defined by F-18-FLT PET scanning

المؤلفون: Jan Jacob Schuringa, Edo Vellenga, Ali Agool, Carolien M. Woolthuis, Sandra Olthof, Riemer H. J. A. Slart, G. Huls, W. M. Smid

المساهمون: Faculteit Medische Wetenschappen/UMCG, University of Groningen, Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Vascular Ageing Programme (VAP), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR)

المصدر: Bone marrow transplantation, 46(1), 110-115. Nature Publishing Group

مصطلحات موضوعية: Adult, Pathology, medicine.medical_specialty, Myeloid, Lymphoma, CD34, Antigens, CD34, Biology, Transplantation, Autologous, auto-SCT, Colony-Forming Units Assay, Bone Marrow, Granulocyte-Macrophage Progenitor Cells, In vivo, medicine, Humans, Tissue Distribution, Whole Body Imaging, Progenitor cell, Clonogenic assay, Myeloid Progenitor Cells, STAT5, Transplantation, progenitor subsets, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Cell cycle, Molecular biology, BM defects, BONE-MARROW-TRANSPLANTATION, Dideoxynucleosides, Molecular Imaging, Haematopoiesis, Phenotype, medicine.anatomical_structure, surgical procedures, operative, ENGRAFTMENT, CORD-BLOOD-CELLS, Positron-Emission Tomography, cell cycle, Radiopharmaceuticals, Stem cell, INJECTION, HIGH-DOSE THERAPY, Follow-Up Studies, F-18-FLT PET

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8381f7a19e5cd053d7963f812f9d5eTest
https://hdl.handle.net/11370/5332e88c-696d-44fc-8491-df4161c19476Test

4

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells

المؤلفون: Sarah J. Horton, Aleksandra Rizo, Gerald de Haan, Bert Dontje, Ronald van Os, Edo Vellenga, Albertina Ausema, Sandra Olthof, Vincent van den Boom, Jan Jacob Schuringa

المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)

المصدر: Blood, 116(22), 4621-4630. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Myeloid, Immunology, Fusion Proteins, bcr-abl, Gene Expression, ENFORCED EXPRESSION, Antigens, CD34, Mice, SCID, Biology, PHILADELPHIA-CHROMOSOME, Philadelphia chromosome, Biochemistry, Mice, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Proto-Oncogene Proteins, hemic and lymphatic diseases, Tumor Cells, Cultured, MYELOPROLIFERATIVE DISEASE, medicine, Animals, Humans, HEMATOPOIETIC STEM-CELLS, CHRONIC MYELOID-LEUKEMIA, Cell Proliferation, ACUTE LYMPHOBLASTIC-LEUKEMIA, Polycomb Repressive Complex 1, Severe combined immunodeficiency, Gene Expression Regulation, Leukemic, CHRONIC MYELOGENOUS LEUKEMIA, breakpoint cluster region, Nuclear Proteins, STEM/PROGENITOR CELLS, Myeloid leukemia, Cancer, IMPAIRS SELF-RENEWAL, Cell Biology, Hematology, Fetal Blood, Hematopoietic Stem Cells, medicine.disease, Repressor Proteins, Leukemia, Cell Transformation, Neoplastic, medicine.anatomical_structure, IMMUNODEFICIENT MICE, Cancer research, Female, Chronic myelogenous leukemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7088617c19e4b47f468ec8efec55d767Test
https://doi.org/10.1182/blood-2010-02-270660Test

5

Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells

المؤلفون: Sandra Olthof, Monika R. Tyl, Edo Vellenga, Gwenny M. Fuhler, A. Lyndsay Drayer, Nel R. Blom

المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: European Journal of Haematology, 83(3), 235-245. Wiley

مصطلحات موضوعية: Programmed cell death, KINASE-B, Genetic Vectors, Green Fluorescent Proteins, INHIBITION, Bone Marrow Cells, mTORC1, Biology, Mechanistic Target of Rapamycin Complex 1, mTORC2, Rictor, ACTIVATION, Humans, Progenitor cell, RNA, Small Interfering, PHOSPHORYLATION, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Cell Proliferation, PROGENITORS, Cell growth, TOR Serine-Threonine Kinases, RPTOR, THROMBOPOIETIN-INDUCED PROLIFERATION, Proteins, Hematology, General Medicine, Regulatory-Associated Protein of mTOR, Flow Cytometry, CD34(+) CELLS, Cell biology, Raptor, Intracellular signal transduction, Phosphotransferases (Alcohol Group Acceptor), Rapamycin-Insensitive Companion of mTOR Protein, Gene Expression Regulation, MAMMALIAN TARGET, RIBOSOMAL-PROTEIN S6, Multiprotein Complexes, Carrier Proteins, RAPAMYCIN, Megakaryocytes, megakaryopoiesis, signal transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ccfac970830f3c89afaf18ac44d0f8Test
https://doi.org/10.1111/j.1600-0609.2009.01263.xTest

6

Plant Sterols Cause Macrothrombocytopenia in a Mouse Model of Sitosterolemia

المؤلفون: Gerald de Haan, Sandra Olthof, A. Lyndsay Drayer, Ido P. Kema, Vincent W. Bloks, Pieter J. J. Sauer, Nel R. Blom, Folkert Kuipers, Janine K. Kruit, Edo Vellenga

المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM)

المصدر: The Journal of Biological Chemistry, 283(10), 6281-6287. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

مصطلحات موضوعية: Blood Platelets, medicine.medical_specialty, BILIARY CHOLESTEROL SECRETION, Lipoproteins, ABCG5, ABCG8, Biology, Biochemistry, Lipid Metabolism, Inborn Errors, RED-BLOOD-CELLS, Mice, Megakaryocyte, Internal medicine, medicine, Animals, Platelet, ATP Binding Cassette Transporter, Subfamily G, Member 5, Liver X receptor, Molecular Biology, DIETARY-CHOLESTEROL, Bone Marrow Transplantation, Cell Size, Mice, Knockout, Platelet Count, PARENTERAL-NUTRITION, ATP Binding Cassette Transporter, Subfamily G, Member 8, Cell Biology, medicine.disease, Sitosterols, Thrombocytopenia, Sterol, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, IDIOPATHIC THROMBOCYTOPENIC PURPURA, Intestinal Absorption, Inborn error of metabolism, XANTHOMATOSIS, ATP-Binding Cassette Transporters, Bone marrow, LIVER-X-RECEPTOR, BETA-SITOSTEROLEMIA, Megakaryocytes, Sitosterolemia

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc76d544f8a30d3007e1eaffbf6bed7Test
https://doi.org/10.1074/jbc.m706689200Test

7

Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell–derived factor-1–induced migration of CD34+ cells from patients with myelodysplasia

المؤلفون: Jan Jacob Schuringa, Gwenny M. Fuhler, Edo Vellenga, Sandra Olthof, Paul J. Coffer, A. Lyndsay Drayer

المساهمون: University of Groningen, Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)

المصدر: Blood, 111(1), 359-368. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Adult, rho GTP-Binding Proteins, Stromal cell, MAP Kinase Signaling System, Polymers, Immunology, Antigens, CD34, HL-60 Cells, NEUTROPHIL CHEMOTAXIS, Biochemistry, Phosphatidylinositol 3-Kinases, Cell Movement, Humans, SIGNAL-REGULATED KINASE, RESPIRATORY BURST, Stromal cell-derived factor 1, Neural Tube Defects, Progenitor cell, PHOSPHORYLATION, Protein kinase B, Aged, Aged, 80 and over, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, ROLES, Phosphoinositide 3-kinase, biology, Kinase, STEM/PROGENITOR CELLS, Cell Biology, Hematology, Middle Aged, Actins, Chemokine CXCL12, rac GTP-Binding Proteins, HEMATOPOIETIC PROGENITOR CELLS, Cell biology, biology.protein, Cancer research, PHOSPHATIDYLINOSITOL 3-KINASE, Stem cell, Signal transduction, MEDIATED INTERACTION, Proto-Oncogene Proteins c-akt, STEM-CELLS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82e1f2ae84f402850460f0719827f2aTest
https://doi.org/10.1182/blood-2006-11-060632Test

8

Mammalian target of rapamycin is required for thrombopoietin-induced proliferation of megakaryocyte progenitors

المؤلفون: A. Lyndsay Drayer, Sandra Olthof, Edo Vellenga

المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: STEM CELLS, 24(1), 105-114. Wiley-Blackwell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f291aca41bb745ed0312f9ac296206Test
https://doi.org/10.1634/stemcells.2005-0062Test

9

Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells

المؤلفون: Sandra Olthof, Alice Gerrits, Leonid Bystrykh, Martha Ritsema, Gerald de Haan, Ellen Weersing, Marta A. Walasek, Erik Zwart, Ronald van Os

المساهمون: Faculteit Medische Wetenschappen/UMCG, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL)

المصدر: Blood, 119(2), 377-387. AMER SOC HEMATOLOGY

مصطلحات موضوعية: EXPRESSION, Male, Cell type, Immunology, Biology, FREQUENCY, Real-Time Polymerase Chain Reaction, Biochemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, Erythroid Cells, Animals, Myeloid Cells, Progenitor cell, Gene, Cells, Cultured, 030304 developmental biology, Oligonucleotide Array Sequence Analysis, NUMBERS, 0303 health sciences, Gene Expression Profiling, PROLIFERATION, ALLOPHENIC MICE, Cell Biology, Hematology, Hematopoietic Stem Cells, Molecular biology, Gene expression profiling, Transplantation, Mice, Inbred C57BL, Haematopoiesis, MicroRNAs, DIFFERENTIATION, 030220 oncology & carcinogenesis, Mice, Inbred CBA, POPULATIONS, Female, Stem cell, STEM-CELLS, LEUKEMIA, GENOMICS, Biomarkers, Genetic screen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42a239ebe2e58ec2fc363f688519e61Test
https://pubmed.ncbi.nlm.nih.gov/22123844Test

10

Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis

المؤلفون: Gerald de Haan, Sandra Olthof, Edo Vellenga, Aleksandra Rizo, Jan Jacob Schuringa, Lina Han

المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)

المصدر: Blood, 114(8), 1498-1505. AMER SOC HEMATOLOGY

مصطلحات موضوعية: Stromal cell, Immunology, Cell, Antigens, CD34, Apoptosis, macromolecular substances, ACUTE MYELOID-LEUKEMIA, Biology, Biochemistry, Proto-Oncogene Proteins, medicine, Humans, HEMATOPOIETIC STEM-CELLS, RNA, Small Interfering, Progenitor cell, OXIDATIVE STRESS, Cells, Cultured, Cell Proliferation, Polycomb Repressive Complex 1, LONG-TERM MAINTENANCE, Blood Cells, POLYCOMB-GROUP GENE, MOLECULAR MARKER, DEVELOPMENTAL REGULATORS, Infant, Newborn, Nuclear Proteins, STEM/PROGENITOR CELLS, MOUSE DEVELOPMENT, Cell Biology, Hematology, Fetal Blood, Hematopoietic Stem Cells, medicine.disease, Blood Cell Count, Repressor Proteins, Endothelial stem cell, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Cord blood, Cancer research, RNA Interference, Bone marrow, Stem cell, Reactive Oxygen Species, HISTONE METHYLTRANSFERASE ACTIVITY

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8656012db4dbcd013d62ead485a48beTest
https://research.rug.nl/en/publications/0bdc6730-75b6-409d-aeab-ed0423bebe50Test

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