A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility
| العنوان: | A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility |
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| المؤلفون: | Samara Rabelo Medeiros, Debra J. Palmer, Jessica Metcalfe, Samantha Zanelli, Nicolas Halloin, Susan L. Prescott, Patricia Macchiaverni, Valérie Verhasselt, Chrystelle Bonnart, Meri K. Tulic, Jon Genuneit, Akila Rekima, Samah Rekima |
| المساهمون: | School of Molecular Sciences, The University of Western Australia (UWA), Institut National de la Santé et de la Recherche Médicale (INSERM), Telethon KIDS Institute, Université de Nice Sophia-Antipolis (UNSA), Worldwide Universities Network, Partenaires INRAE, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire LTEE, Universidade Federal de Minas Gerais, University of Western Australia, ProdInra, Migration, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA) |
| المصدر: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2020, pp.1-25. ⟨10.1016/j.jaci.2019.12.912⟩ Journal of Allergy and Clinical Immunology, 2020, pp.1-25. ⟨10.1016/j.jaci.2019.12.912⟩ |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Dermatophagoides pteronyssinus, Administration, Oral, 0302 clinical medicine, Pregnancy, Lactation, Intestine, Small, Immunology and Allergy, 2. Zero hunger, Mice, Inbred BALB C, biology, Innate lymphoid cell, 3. Good health, Cysteine Endopeptidases, Milk, medicine.anatomical_structure, Female, Disease Susceptibility, Adult, Ovalbumin, Immunology, Mice, Transgenic, Breast milk, Arthropod Proteins, House dust mite, 03 medical and health sciences, Double-Blind Method, Food allergy, medicine, Animals, Humans, Antigens, Dermatophagoides, Egg Hypersensitivity, food allergy, business.industry, Infant, Newborn, protease, Allergens, Immunoglobulin E, Interleukin-33, biology.organism_classification, medicine.disease, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, 030228 respiratory system, breast-feeding, Egg allergy, biology.protein, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Breast feeding |
| الوصف: | International audience; Background: Successful prevention of food allergy requires the identification of the factors adversely affecting the capacity to develop oral tolerance to food antigen in early life. Objectives: This study sought to determine whether oral exposure to Dermatophagoides pteronyssinus through breast milk affects gut mucosal immunity with long-term effects on IgE-mediated food allergy susceptibility. Methods: Gut immunity was explored in 2-week-old mice breast-fed by mothers exposed to D pteronyssinus, protease-inactivated D pteronyssinus, or to PBS during lactation. We further analyzed oral tolerance to a bystander food allergen, ovalbumin (OVA). In a proof-of-concept study, Der p 1 and OVA levels were determined in 100 human breast milk samples and the association with prevalence of IgE-mediated egg allergy at 1 year was assessed. Results: Increased permeability, IL-33 levels, type 2 innate lymphoid cell activation, and TH2 cell differentiation were found in gut mucosa of mice nursed by mothers exposed to D pteronyssinus compared with PBS. This pro-TH2 gut mucosal environment inhibited the induction of antigen-specific FoxP3 regulatory T cells and the prevention of food allergy by OVA exposure through breast milk. In contrast, protease-inactivated D pteronyssinus had no effect on offspring gut mucosal immunity. Based on the presence of Der p 1 and/or OVA in human breast milk, we identified groups of lactating mothers, which mirror the ones found in mice to be responsible for different egg allergy risk. Conclusions: This study highlights an unpredicted potential risk factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk, which disrupt gut immune homeostasis and prevents oral tolerance induction to bystander food antigen through their protease activity. © 2020 American Academy of Allergy, Asthma & Immunology |
| تدمد: | 0091-6749 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e81e863bce2ec4775c2d1f844ca1fa7Test https://doi.org/10.1016/j.jaci.2019.12.912Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9e81e863bce2ec4775c2d1f844ca1fa7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00916749 |
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