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1دورية أكاديمية
المؤلفون: Linda Sundström, Susanna Myhre, Monika Sundqvist, Andrea Ahnmark, William McCoull, Piotr Raubo, Sam D Groombridge, Magnus Polla, Ann-Christin Nyström, Lisbeth Kristensson, Mats Någård, Maria Sörhede Winzell
المصدر: PLoS ONE, Vol 12, Iss 12, p e0189060 (2017)
وصف الملف: electronic resource
العلاقة: http://europepmc.org/articles/PMC5716539?pdf=renderTest; https://doaj.org/toc/1932-6203Test
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المؤلفون: Iain A. Cumming, Sébastien L. Degorce, Anna Aagaard, Erin L. Braybrooke, Nichola L. Davies, Coura R. Diène, Andrew J. Eatherton, Hannah R. Felstead, Sam D. Groombridge, Eva M. Lenz, Yunxia Li, Youfeng Nai, Stuart Pearson, Graeme R. Robb, James S. Scott, Oliver R. Steward, Chengyan Wu, Yafeng Xue, Lanping Zhang, Yanxiu Zhang
المصدر: Bioorganicmedicinal chemistry. 63
مصطلحات موضوعية: Structure-Activity Relationship, Interleukin-1 Receptor-Associated Kinases, Pyridones, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Molecular Conformation, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a392e9908e5c3f41f7d9cc5004c347Test
https://pubmed.ncbi.nlm.nih.gov/35439688Test -
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المؤلفون: Scott G. Lamont, Robert D. M. Davies, Christopher J. Morrow, Thomas A. Moss, Andrew Lister, Eric Gangl, Rodrigo J. Carbajo, Paul R. J. Davey, Craig S. Donald, James S. Scott, Tony Johnson, Sébastien L. Degorce, Jon Curwen, Mandy Lawson, Sam D. Groombridge, David Buttar, Radoslaw Polanski, Ryan Greenwood, Andrew Bailey, Jennifer H. Pink
المصدر: Journal of Medicinal Chemistry. 62:1593-1608
مصطلحات موضوعية: Male, Indazoles, Stereochemistry, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, SCID, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Indazole, Molecular Structure, Tetrahydroisoquinoline, Aryl, Estrogen Receptor alpha, Glutathione, Xenograft Model Antitumor Assays, In vitro, Rats, chemistry, MCF-7 Cells, Microsomes, Liver, Molecular Medicine, Estrogen Receptor Antagonists, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Tricyclic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c4372ee1b0b56453fd933c416388e4Test
https://doi.org/10.1021/acs.jmedchem.8b01837Test -
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المؤلفون: Keith Dillman, J. Elizabeth Pease, James E. Dowling, Nichola L. Davies, Rana Anjum, Robert D. M. Davies, Janet D. Culshaw, David R. Perkins, Dedong Wu, Julian A. Hudson, Sébastien L. Degorce, Jennifer H. Pink, Nicola Lindsay, Christopher Thomas Halsall, James S. Scott, Scott G. Lamont, Minhui Shen, Andrew D. Ferguson, Alan Rosen, Lisa Drew, Stacey Marden, Claire McWhirter, Sam D. Groombridge, Michele Mayo, Graeme R. Robb
المصدر: Journal of Medicinal Chemistry. 60:10071-10091
مصطلحات موضوعية: 0301 basic medicine, biology, Kinase, Mutant, medicine.disease, IRAK4, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Biochemistry, chemistry, immune system diseases, In vivo, hemic and lymphatic diseases, Ibrutinib, Drug Discovery, Cancer research, medicine, biology.protein, Molecular Medicine, Bruton's tyrosine kinase, Receptor, Diffuse large B-cell lymphoma
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7d9445739130c614b1133a78291bf074Test
https://doi.org/10.1021/acs.jmedchem.7b01290Test -
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المؤلفون: Yafeng Xue, Lisa Drew, Rana Anjum, Sébastien L. Degorce, Keith Dillman, James S. Scott, Christopher Thomas Halsall, Sam D. Groombridge, Stephen Stokes, Jennifer H. Pink, Eva M. Lenz, Nicola Lindsay, Michele Mayo, Graeme R. Robb
المصدر: Bioorganicmedicinal chemistry. 26(4)
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Mutant, Thiazines, Pharmaceutical Science, Molecular Dynamics Simulation, Biochemistry, Permeability, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, In vivo, hemic and lymphatic diseases, Drug Discovery, Low permeability, Bruton's tyrosine kinase, Animals, Humans, Pyrroles, Molecular Biology, Binding Sites, biology, Organic Chemistry, IRAK4, Combinatorial chemistry, Rats, 030104 developmental biology, Interleukin-1 Receptor-Associated Kinases, chemistry, Permeability (electromagnetism), 030220 oncology & carcinogenesis, Ibrutinib, Drug Design, Mutation, Myeloid Differentiation Factor 88, biology.protein, Hepatocytes, Molecular Medicine, Efflux, Lymphoma, Large B-Cell, Diffuse, Caco-2 Cells, Protein Kinases, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96a864f63d65def4ea1c7ab68158308Test
https://pubmed.ncbi.nlm.nih.gov/29398441Test -
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المؤلفون: James S, Scott, Sébastien L, Degorce, Rana, Anjum, Janet, Culshaw, Robert D M, Davies, Nichola L, Davies, Keith S, Dillman, James E, Dowling, Lisa, Drew, Andrew D, Ferguson, Sam D, Groombridge, Christopher T, Halsall, Julian A, Hudson, Scott, Lamont, Nicola A, Lindsay, Stacey K, Marden, Michele F, Mayo, J Elizabeth, Pease, David R, Perkins, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, Minhui, Shen, Claire, McWhirter, Dedong, Wu
المصدر: Journal of medicinal chemistry. 60(24)
مصطلحات موضوعية: Male, Magnetic Resonance Spectroscopy, Administration, Oral, Antineoplastic Agents, Mice, SCID, Crystallography, X-Ray, Xenograft Model Antitumor Assays, Structure-Activity Relationship, Dogs, Interleukin-1 Receptor-Associated Kinases, Pyrimidines, Cell Line, Tumor, Mutation, Myeloid Differentiation Factor 88, Animals, Humans, Female, Pyrroles, Lymphoma, Large B-Cell, Diffuse, Rats, Wistar, Protein Kinase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d0123c6a11a82f0bdcbd73931a51e9a3Test
https://pubmed.ncbi.nlm.nih.gov/29172502Test -
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المؤلفون: Stephen Stokes, Sébastien L. Degorce, Scott Boyd, Robert D. M. Davies, James S. Scott, Sam D. Groombridge
المصدر: Tetrahedron Letters. 57:152-154
مصطلحات موضوعية: Reaction sequence, 010405 organic chemistry, Chemistry, Pummerer rearrangement, Organic Chemistry, Drug Discovery, Organic chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::61748719e1bcd4c8a29667b1ec85108eTest
https://doi.org/10.1016/j.tetlet.2015.11.083Test -
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المؤلفون: Scott G. Lamont, Sam D. Groombridge, J. Lyman Feron, Craig S. Donald
المصدر: Tetrahedron Letters. 56:7165-7167
مصطلحات موضوعية: Indole test, chemistry.chemical_classification, Carbazole, Organic Chemistry, Regioselectivity, Benzothiophene, Alkylation, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Nitro, Organic chemistry, Benzofuran, Alkyl
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::69efde40ead5373228fbfa66cdc8a38bTest
https://doi.org/10.1016/j.tetlet.2015.11.036Test -
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المؤلفون: Lisbeth Kristensson, Maria Sörhede Winzell, Sam D. Groombridge, Piotr Raubo, Andrea Ahnmark, William McCoull, Monika Sundqvist, Susanna Myhre, Polla Magnus, Ann-Christin Nyström, Linda Sundström, Mats Någård
المصدر: PLoS ONE, Vol 12, Iss 12, p e0189060 (2017)
PLoS ONEمصطلحات موضوعية: Blood Glucose, 0301 basic medicine, Physiology, Oral Glucose Suppression Test, medicine.medical_treatment, lcsh:Medicine, Pharmacology, Biochemistry, Receptors, G-Protein-Coupled, Mice, Endocrinology, Glucose Metabolism, Drug Metabolism, Glucagon-Like Peptide 1, Insulin Secretion, Cyclic AMP, Medicine and Health Sciences, Insulin, lcsh:Science, beta-Arrestins, Glucose tolerance test, Multidisciplinary, medicine.diagnostic_test, Organic Compounds, Chemistry, Monosaccharides, Receptor antagonist, Physical Sciences, Carbohydrate Metabolism, Female, Signal Transduction, Research Article, Agonist, Cell Physiology, Gs alpha subunit, medicine.drug_class, Carbohydrates, CHO Cells, Carbohydrate metabolism, Cell Line, Islets of Langerhans, 03 medical and health sciences, Cricetulus, GTP-Binding Proteins, In vivo, medicine, Animals, Humans, Pharmacokinetics, Secretion, Diabetic Endocrinology, Endocrine Physiology, Beta-Arrestins, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, Cell Biology, Glucose Tolerance Test, Hormones, Cell Metabolism, Pharmacologic-Based Diagnostics, Mice, Inbred C57BL, Metabolism, Glucose, 030104 developmental biology, lcsh:Q, Physiological Processes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d403700840ffcd7ea5ecb0444d62da4bTest
http://europepmc.org/articles/PMC5716539?pdf=renderTest -
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المؤلفون: Frederick W. Goldberg, Andrew V. Turnbull, Joanne deSchoolmeester, Martin Wild, Graeme R. Robb, Paul D. Kemmitt, James S. Scott, Scott Boyd, John G. Swales, Tove Sjögren, Pablo Morentin Gutierrez, Sam D. Groombridge, Alexander G. Dossetter
المصدر: Journal of Medicinal Chemistry. 57:970-986
مصطلحات موضوعية: Blood Glucose, Cyclopropanes, Male, Models, Molecular, medicine.medical_treatment, Central nervous system, Mice, Obese, Adamantane, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, In vivo, Diabetes mellitus, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Potency, Structure–activity relationship, Metabolic Syndrome, Chemistry, Body Weight, Brain, Stereoisomerism, medicine.disease, Dietary Fats, Rats, Isoenzymes, Mice, Inbred C57BL, Thiazoles, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Liver, Pyrazoles, Molecular Medicine, Metabolic syndrome, Diet-induced obese
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3685bf6571883221c3da774cf39012Test
https://doi.org/10.1021/jm4016729Test