دورية أكاديمية
Vitamin D status as a predictor for liver transplant outcomes
| العنوان: | Vitamin D status as a predictor for liver transplant outcomes |
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| المؤلفون: | Fotros, Danial, Sohouli, Mohammadhassan, Yari, Zahra, Sakhdari, Hanie, Shafiekhani, Mojtaba, Nikoupour, Hamed, Jafarzadeh, Mohammad Amin, Jafari, Keynoosh, Afiatjoo, Seyedeh Sara, Fatemi, Seyed Amirreza, Amiri, Mahmoud, Eghlimi, Hesameddin, Rabbani, Amirhassan, Broumandnia, Nasrin, Mazdeh, Ghazaleh Mahdavi, Jafarian, Ali, Hekmatdoost, Azita |
| المصدر: | Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | It is well known that vitamin D plays a pivotal role in immune system modulation; however, its role in liver transplantation (LT) has not yet been well elucidated. This study aimed to assess the association between vitamin D status and LT outcomes. This retrospective cohort study was conducted on 335 registered cirrhotic patients with end-stage liver disease (ESLD) who underwent LT during 2019–2021 and had measurement of serum vitamin D before LT. The association of vitamin D levels before LT with the odds of acute cellular rejection (ACR) and risk mortality was assessed by applying logistic and cox regression, respectively. The mean MELD-Na and serum level of vitamin D were 20.39 ± 9.36 and 21.52 ± 15.28 ng/ml, respectively. In the final adjusted model, there was a significant association between vitamin D deficiency in the pre-transplant period and odds of ACR (odds ratio [OR] 2.69; 95% confidence interval [CI] 1.50–4.68). Although in the crude model, vitamin D deficiency in the pre-transplant period was significantly associated with an increased risk of mortality after two years of follow-up (Hazard ratio (HR) = 2.64, 95% CI 1.42–4.33), after adjustment for potential confounders, the association of vitamin D status and mortality became non-significant (HR = 1.46, 95% CI 0.71–3.00). The present study provides evidence that pre-transplant serum vitamin D levels may be a predictor for ACR in patients with cirrhosis undergoing LT. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-023-48496-5 |
| الإتاحة: | https://doi.org/10.1038/s41598-023-48496-5Test https://www.nature.com/articles/s41598-023-48496-5.pdfTest https://www.nature.com/articles/s41598-023-48496-5Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.A2E01FF3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-023-48496-5 |
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