دورية أكاديمية
Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering
| العنوان: | Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering |
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| المؤلفون: | Fatemehsadat Mousavinasab, Ronika karimi, Sima Taheri, Fatemeh Ahmadvand, Saameh Sanaaee, Sajad Najafi, Masood Soltani Halvaii, Alireza Haghgoo, Marzieh Zamany, Jamal Majidpoor, Mina Khosravifar, Mohammad Baniasadi, Mehrdad Talebi, Abolfazl Movafagh, Seyed Mohsen Aghaei-Zarch, Nastaran Khorram, Poopak Farnia, Kambiz Kalhor |
| المصدر: | Cancer Cell International, Vol 23, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Microbiome, Genetic Engineering, Inflammatory diseases, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Recent developments in sequencing technology and analytical approaches have allowed researchers to show that the healthy gut microbiome is very varied and capable of performing a wide range of tasks. The importance of gut microbiota in controlling immunological, neurological, and endocrine function is becoming well-recognized. Thereby, numerous inflammatory diseases, including those that impact the gastrointestinal system, as well as less obvious ones, including Rheumatoid arthritis (RA), cancer, gestational diabetes (GD), type 1 diabetes (T1D), and type 2 diabetes (T2D), have been linked to dysbiotic gut microbiota. Microbiome engineering is a rapidly evolving frontier for solutions to improve human health. Microbiome engineering seeks to improve the function of an ecosystem by manipulating the composition of microbes. Thereby, generating potential therapies against metabolic, inflammatory, and immunological diseases will be possible through microbiome engineering. This essay first provides an overview of the traditional technological instruments that might be used for microbiome engineering, such as Fecal Microbiota Transplantation (FMT), prebiotics, and probiotics. Moreover, we will also discuss experimental genetic methods such as Metagenomic Alteration of Gut microbiome by In situ Conjugation (MAGIC), Bacteriophage, and Conjugative plasmids in manipulating intestinal microbiota. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2867 |
| العلاقة: | https://doaj.org/toc/1475-2867Test |
| DOI: | 10.1186/s12935-023-03095-2 |
| الوصول الحر: | https://doaj.org/article/641e2c3abf0c4781a0569ccd663edb1bTest |
| رقم الانضمام: | edsdoj.641e2c3abf0c4781a0569ccd663edb1b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14752867 |
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| DOI: | 10.1186/s12935-023-03095-2 |