التفاصيل البيبلوغرافية
| العنوان: |
Brain Tumor Microenvironment and Angiogenesis in Melanoma Brain Metastases |
| المؤلفون: |
Trembath, Dimitri G., Davis, Eric S., Rao, Shanti, Bradler, Evan, Saada, Angelica F., Midkiff, Bentley R., Snavely, Anna C., Ewend, Matthew G., Collichio, Frances A., Lee, Carrie B., Karachaliou, Georgia-Sofia, Ayvali, Fatih, Ollila, David W., Krauze, Michal T., Kirkwood, John M., Vincent, Benjamin G., Nikolaishvilli-Feinberg, Nana, Moschos, Stergios J. |
| المساهمون: |
National Cancer Institute |
| المصدر: |
Frontiers in Oncology ; volume 10 ; ISSN 2234-943X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Cancer Research, Oncology |
| الوصف: |
Background High tumor-infiltrating lymphocytes (TILs) and hemorrhage are important prognostic factors in patients who have undergone craniotomy for melanoma brain metastases (MBM) before 2011 at the University of Pittsburgh Medical Center (UPMC). We have investigated the prognostic or predictive role of these histopathologic factors in a more contemporary craniotomy cohort from the University of North Carolina at Chapel Hill (UNC-CH). We have also sought to understand better how various immune cell subsets, angiogenic factors, and blood vessels may be associated with clinical and radiographic features in MBM. Methods Brain tumors from the UPMC and UNC-CH patient cohorts were (re)analyzed by standard histopathology, tumor tissue imaging, and gene expression profiling. Variables were associated with overall survival (OS) and radiographic features. Results The patient subgroup with high TILs in craniotomy specimens and subsequent treatment with immune checkpoint inhibitors (ICIs, n=7) trended to have longer OS compared to the subgroup with high TILs and no treatment with ICIs (n=11, p=0.059). Bleeding was significantly associated with tumor volume before craniotomy, high melanoma-specific expression of basic fibroblast growth factor (bFGF), and high density of CD31+αSMA- blood vessels. Brain tumors with high versus low peritumoral edema before craniotomy had low (17%) versus high (41%) incidence of brisk TILs. Melanoma-specific expression of the vascular endothelial growth factor (VEGF) was comparable to VEGF expression by TILs and was not associated with any particular prognostic, radiographic, or histopathologic features. A gene signature associated with gamma delta (gd) T cells was significantly higher in intracranial than same-patient extracranial metastases and primary melanoma. However, gdT cell density in MBM was not prognostic. Conclusions ICIs may provide greater clinical benefit in patients with brisk TILs in MBM. Intratumoral hemorrhage in brain metastases, a significant clinical problem, is not merely ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fonc.2020.604213 |
| DOI: |
10.3389/fonc.2020.604213/full |
| الإتاحة: |
https://doi.org/10.3389/fonc.2020.604213Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.45C24B40 |
| قاعدة البيانات: |
BASE |
