Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review

التفاصيل البيبلوغرافية
العنوان: Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review
المؤلفون: Jihye Lee, Hee-Seop Lee, Seong-Ho Lee, Dmitriy Smolensky
المصدر: International Immunopharmacology
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: ERK, Extracellular signal-Regulated Kinase, HPU, Helicobactor Pylori Urease, IR, Ischemia/reperfusion, iNOS, Inducible Nitric Oxide Synthase, PERK, Protein kinase R-like Endoplasmic Reticulum Kinase, Alcohol, C/EBPα, CCAT/enhancer Binding Protein α, RIP3, Receptor Interacting Serine/Threonine- Protein kinase3, CXCL11, C-X-C Motif Chemokine 11, IBD, Inflammatory Bowel Disease, DCNB, 2,4-Dinitro-chlorobenzene, IRE1, Inositol-requiring Enzyme 1, 0302 clinical medicine, ACE2, Angiotensin Converting Enzyme 2, Medicine, 4E-BP1, Eukaryotic Translation Initiation Factor 4E Binding Protein 1, SOD, Superoxide Dismutase, 5-HT, 5-Hydroxytryptamine, LPS, Lipopolysaccharide, TLR2, Toll-like Receptor 2, media_common, ER, Estrogen Receptor, IFNγ, Interferon γ, Nrf2, Nuclear Factor Erythroid 2-Related Factor 2, NF-κB, Nuclear Factor κ-light-chain-enhancer of activated B cells, VDCC, Voltage-Dependent Ca2+ Channel, Pogostemon, SYN1, Synapsin-1, PXR, Pregnane X Receptor, 030220 oncology & carcinogenesis, IP3R, Inositol Triphosphate Receptor, Sesquiterpenes, PSD-95, Postsynaptic Density Protein 95, TPH1, Tryptophan Hydroxylase 1, Drug, media_common.quotation_subject, Immunology, CUMS, Chronic Unpredictable Mild Stress, ZO-1, Zonula Occludens-1, Article, WHO, World Health Organization, 03 medical and health sciences, food, ICAM-1, Intracellular Adhesion Molecule-1, Humans, VLDL, Very Low Density Lipoprotein, Pharmacology, IDO-1, Indoleamine 2,3-dioxygenease-1, TNFα, Tumor Necrosis Factor α, MAPK, Mitogen-Activated Protein Kinase, NO, Nitric Oxide, CAT, Catalase, 030104 developmental biology, Patchouli alcohol, mTOR, Mammalian Target of Rapamycin, chemistry, PI3K, Phosphoinositol-3 Kinase, RdRp, RNA-Dependent RNA Polymerase, 0301 basic medicine, CXCL10, C-X-C Motif Chemokine 10, PLpro, Papain-like Protease, Anti-Inflammatory Agents, 3CLpro, 3C-Like Protease, PGE2, Prostaglandin E2, Health benefits, COX2, Cyclooxygenase 2, MLKL, Mixed Lineage Kinase Domain-Like Pseudokinase, chemistry.chemical_compound, 5-FU, 5-Fluorouracil, Immunology and Allergy, CXCL9, C-X-C Motif Chemokine 9, eNOS, Endothelial Nitric Oxide Synthase, biology, Traditional medicine, respiratory system, 5-HTP, 5-Hydroxytryptophan, VCAM-1, Vascular Cell Adhesion Molecule 1, NLRP3, NOD-, LRR- and Pyrin Domain-containing Protein 3, Immunosuppressive Agents, food.ingredient, ATF6, Activating Transcription Factor 6, DSS, Dextran Sulfate Sodium, TXNIP, Thioredoxin Interacting Protein, ROCCs, Receptor-operated Ca2+ Channels, Functional food, PA, Patchouli Alcohol, SCFA, Short Chain Fatty Acid, MDA, Malondialdehyde, Biological mechanisms, RyRs, Ryanodine Receptors, Lung protection, business.industry, PHE, Phenylephrine, GSH-px, Glutathione Peroxidase, MMP9, Matrix Metalloproteinase 9, biology.organism_classification, Antineoplastic Agents, Phytogenic, DTH, Delayed Type Hypersensitivity, PPARγ, Peroxisome Proliferator Activated Receptor γ, HO-1, Heme Oxidase-1, Molecular targets, EGFR, Epidermal Growth Factor Receptor, Kyn, L-Kynurenine, MCP-1, Monocyte Chemoattractant Protein-1, Patchouli, business, human activities, ROS, Reactive Oxygen Species
الوصف: Highlights • Patchouli alcohol (PA) is a bioactive component in essential oil extracted from Pogostemon cablin. • The present review provides the scientific mechanisms for health beneficial activities of PA in diverse disease models. • PA possesses diverse health beneficial activities.
Patchouli alcohol (PA), a tricyclic sesquiterpene, is a dominant bioactive component in oil extracted from the aerial parts of Pogostemon cablin (patchouli). Diverse beneficial activities have been reported, including anti-influenza virus, anti-depressant, anti-nociceptive, vasorelaxation, lung protection, brain protection, anti-ulcerogenic, anti-colitis, pre-biotic-like, anti-inflammatory, anti-cancer and protective activities against metabolic diseases. However, detailed mechanistic studies are required to explore the possibility of developing PA as a functional food material or promising drug for the prevention and treatment of human diseases. This review highlights multiple molecular targets and working mechanisms by which PA mediates health benefits.
تدمد: 1567-5769
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0bef40b542aa0945c4a6b4a7afa05Test
https://doi.org/10.1016/j.intimp.2020.107056Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....52e0bef40b542aa0945c4a6b4a7afa05
قاعدة البيانات: OpenAIRE