التفاصيل البيبلوغرافية
العنوان:
Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review
المؤلفون:
Jihye Lee , Hee-Seop Lee , Seong-Ho Lee , Dmitriy Smolensky
المصدر:
International Immunopharmacology
بيانات النشر:
Elsevier BV, 2020.
سنة النشر:
2020
مصطلحات موضوعية:
ERK, Extracellular signal-Regulated Kinase , HPU, Helicobactor Pylori Urease , IR, Ischemia/reperfusion , iNOS, Inducible Nitric Oxide Synthase , PERK, Protein kinase R-like Endoplasmic Reticulum Kinase , Alcohol , C/EBPα, CCAT/enhancer Binding Protein α , RIP3, Receptor Interacting Serine/Threonine- Protein kinase3 , CXCL11, C-X-C Motif Chemokine 11 , IBD, Inflammatory Bowel Disease , DCNB, 2,4-Dinitro-chlorobenzene , IRE1, Inositol-requiring Enzyme 1 , 0302 clinical medicine , ACE2, Angiotensin Converting Enzyme 2 , Medicine , 4E-BP1, Eukaryotic Translation Initiation Factor 4E Binding Protein 1 , SOD, Superoxide Dismutase , 5-HT, 5-Hydroxytryptamine , LPS, Lipopolysaccharide , TLR2, Toll-like Receptor 2 , media_common , ER, Estrogen Receptor , IFNγ, Interferon γ , Nrf2, Nuclear Factor Erythroid 2-Related Factor 2 , NF-κB, Nuclear Factor κ-light-chain-enhancer of activated B cells , VDCC, Voltage-Dependent Ca2+ Channel , Pogostemon , SYN1, Synapsin-1 , PXR, Pregnane X Receptor , 030220 oncology & carcinogenesis , IP3R, Inositol Triphosphate Receptor , Sesquiterpenes , PSD-95, Postsynaptic Density Protein 95 , TPH1, Tryptophan Hydroxylase 1 , Drug , media_common.quotation_subject , Immunology , CUMS, Chronic Unpredictable Mild Stress , ZO-1, Zonula Occludens-1 , Article , WHO, World Health Organization , 03 medical and health sciences , food , ICAM-1, Intracellular Adhesion Molecule-1 , Humans , VLDL, Very Low Density Lipoprotein , Pharmacology , IDO-1, Indoleamine 2,3-dioxygenease-1 , TNFα, Tumor Necrosis Factor α , MAPK, Mitogen-Activated Protein Kinase , NO, Nitric Oxide , CAT, Catalase , 030104 developmental biology , Patchouli alcohol , mTOR, Mammalian Target of Rapamycin , chemistry , PI3K, Phosphoinositol-3 Kinase , RdRp, RNA-Dependent RNA Polymerase , 0301 basic medicine , CXCL10, C-X-C Motif Chemokine 10 , PLpro, Papain-like Protease , Anti-Inflammatory Agents , 3CLpro, 3C-Like Protease , PGE2, Prostaglandin E2 , Health benefits , COX2, Cyclooxygenase 2 , MLKL, Mixed Lineage Kinase Domain-Like Pseudokinase , chemistry.chemical_compound , 5-FU, 5-Fluorouracil , Immunology and Allergy , CXCL9, C-X-C Motif Chemokine 9 , eNOS, Endothelial Nitric Oxide Synthase , biology , Traditional medicine , respiratory system , 5-HTP, 5-Hydroxytryptophan , VCAM-1, Vascular Cell Adhesion Molecule 1 , NLRP3, NOD-, LRR- and Pyrin Domain-containing Protein 3 , Immunosuppressive Agents , food.ingredient , ATF6, Activating Transcription Factor 6 , DSS, Dextran Sulfate Sodium , TXNIP, Thioredoxin Interacting Protein , ROCCs, Receptor-operated Ca2+ Channels , Functional food , PA, Patchouli Alcohol , SCFA, Short Chain Fatty Acid , MDA, Malondialdehyde , Biological mechanisms , RyRs, Ryanodine Receptors , Lung protection , business.industry , PHE, Phenylephrine , GSH-px, Glutathione Peroxidase , MMP9, Matrix Metalloproteinase 9 , biology.organism_classification , Antineoplastic Agents, Phytogenic , DTH, Delayed Type Hypersensitivity , PPARγ, Peroxisome Proliferator Activated Receptor γ , HO-1, Heme Oxidase-1 , Molecular targets , EGFR, Epidermal Growth Factor Receptor , Kyn, L-Kynurenine , MCP-1, Monocyte Chemoattractant Protein-1 , Patchouli , business , human activities , ROS, Reactive Oxygen Species
الوصف:
Highlights • Patchouli alcohol (PA) is a bioactive component in essential oil extracted from Pogostemon cablin. • The present review provides the scientific mechanisms for health beneficial activities of PA in diverse disease models. • PA possesses diverse health beneficial activities. Patchouli alcohol (PA), a tricyclic sesquiterpene, is a dominant bioactive component in oil extracted from the aerial parts of Pogostemon cablin (patchouli). Diverse beneficial activities have been reported, including anti-influenza virus, anti-depressant, anti-nociceptive, vasorelaxation, lung protection, brain protection, anti-ulcerogenic, anti-colitis, pre-biotic-like, anti-inflammatory, anti-cancer and protective activities against metabolic diseases. However, detailed mechanistic studies are required to explore the possibility of developing PA as a functional food material or promising drug for the prevention and treatment of human diseases. This review highlights multiple molecular targets and working mechanisms by which PA mediates health benefits.
تدمد:
1567-5769
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e0bef40b542aa0945c4a6b4a7afa05Test https://doi.org/10.1016/j.intimp.2020.107056Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....52e0bef40b542aa0945c4a6b4a7afa05
قاعدة البيانات:
OpenAIRE