التفاصيل البيبلوغرافية
العنوان:
Clinical application of transcriptional activators of bile salt transporters
المؤلفون:
Anna, Baghdasaryan , Peter, Chiba , Michael, Trauner
المصدر:
Molecular Aspects of Medicine
سنة النشر:
2013
مصطلحات موضوعية:
PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha , FXR, farnesoid X receptor (NR1H4) , HNF4α, hepatocyte nuclear factor 4 alpha , CARM1, co-activator-associated arginine methyltransferase 1 , OATP, organic anion transporting polypeptide , VDR (NR1I1), vitamin D receptor , Review , BCRP (ABCG2), breast cancer resistance protein , NDRG2, NMYC downstrean-regulated gene 2 , MRP4 (ABCC4), multidrug resistance-associated protein 4 , SRC2, steroid receptor co-activator 2 , GGT, gamma-glutamyl transpeptidase , MDR1 (ABCB1), multidrug resistance protein 1 , Nuclear receptors , GRE, glucocorticoid response element , CtBP, C-terminal binding protein , GCA, glycocholic acid , TβMCA, β-tauromuricholic acid , TNF-α, tumor necrosis factor alpha , ATB-binding cassette transporters , FGF19/FGF15, fibroblast growth factor 19/15 , MARE, MAF recognition element , ATP Binding Cassette Transporter, Subfamily B, Member 11 , TCDCA, taurochenodeoxycholic acid , CA, cholic acid , Cholestasis , ASBT (SLC10A2), apical sodium-dependent bile acid transporter , Symporters , AE2 (SLC4A2), anion exchanger 2 , ABC, ATP-binding cassette , FXRE, FXR response element , cAMP, cyclic adenosine monophosphate , DILI, drug-induced liver injury , IL-6, interleukin 6 , PL, phospholipid , TGR5, G protein coupled bile acid receptor , OCA, obeticholic acid , OSTα/OSTβ (SLC51A/SLC51B), organic solute transporter alpha/beta , LRH1 (NR5A2), liver receptor homologue 1 , JNK, c-Jun N-terminal kinase , NRF2, nuclear factor erythroid 2-related factor 2 , LPS, lipopolysaccharide , BRIC2, benign recurrent intrahepatic cholestasis type 2 , LXR (NR1H3), liver X receptor , Transcriptional Activation , PFIC2, progressive familial intrahepatic cholestasis type 2 , PXR (NR1I2), pregnane X receptor , TCA, taurocholic acid , RXRα (NR2B1), retinoid X receptor , Organic Anion Transporters, Sodium-Dependent , CCl4, carbone tetrachloride , UDCA, ursodeoxycholic acid , Bile Acids and Salts , CDCA, chenodeoxycholic acid , STAT-5, signal transducer and activator of transcription 5 , LCA, litocholic acid , ALT, alanine aminotransferase , CBDL, common bile duct ligation , IR-1, inverse repeat 1 , TUDCA, tauroursodeoxycholic acid , Humans , ICP, intrahepatic cholestasis of pregnancy , GR (NR3C1), glucocorticoid receptor , MRP2 (ABCC2), multidrug resistance-associated protein 2 , TαMCA, α-tauromuricholic acid , TPN, total parenteral nutrition , ALP, alkaline phosphatase , IL-1β, interleukin-1 beta , SREBP1, sterol regulatory element-binding protein 1 , Membrane Transport Proteins , Biological Transport , BSEP (ABCB11), bile salt export pump , MAF, musculo-aponeurotic fibrosacroma , ASCOM, activating signal cointegrator-2-containing complex , HNF1α, hepatocyte nuclear factor 1 alpha , MCL-1, myeloid cell leukemia factor 1 , NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 , VPAC-1, vasoactive intestinal polypeptide activated receptor , AMPK, AMP-activated protein kinase , MRP3 (ABCC3), multidrug resistance-associated protein 3 , NF-κB, nuclear factor kappa-B , PSC, primary sclerosing cholangitis , Gene Expression Regulation , DCA, deoxycholic acid , BS, bile salt , MDR2 (ABCB4), multidrug resistance protein 2 , PPARα (NR1C1), peroxisome proliferator-activated receptor alpha , SHP (NR0B2), short heterodimer partner , RARα (NR1B1), retinoic acid receptor , ATP-Binding Cassette Transporters , PBC, primary biliary cirrhosis , PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma
الوصف:
Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic circulation. Genetic or acquired dysfunction of specific transport systems causes intrahepatic and systemic retention of potentially cytotoxic BSs, which, in high concentrations, may disturb integrity of cell membranes and subcellular organelles resulting in cell death, inflammation and fibrosis. Transcriptional regulation of canalicular BS efflux through bile salt export pump (BSEP), basolateral elimination through organic solute transporters alpha and beta (OSTα/OSTβ) as well as inhibition of hepatocellular BS uptake through basolateral Na(+)-taurocholate cotransporting polypeptide (NTCP) represent critical steps in protection from hepatocellular BS overload and can be targeted therapeutically. In this article, we review the potential clinical implications of the major BS transporters BSEP, OSTα/OSTβ and NTCP in the pathogenesis of hereditary and acquired cholestatic syndromes, provide an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators of BS transporters in cholestasis.
تدمد:
1872-9452
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=pmid________::02c2316b6e5fe1c1e107f32e273f6aebTest https://pubmed.ncbi.nlm.nih.gov/24333169Test
حقوق:
OPEN
رقم الانضمام:
edsair.pmid..........02c2316b6e5fe1c1e107f32e273f6aeb
قاعدة البيانات:
OpenAIRE
