Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study
| العنوان: | Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study |
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| المؤلفون: | Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M. J., Vrenken, Hugo, Guttmann, Charles R. G., Universitat Autònoma de Barcelona |
| المساهمون: | Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Epidemiology and Data Science, Anatomy and neurosciences, Other Research, APH - Methodology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Institut Català de la Salut, [Burggraaff J, Simoes J] Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Liu Y, de Sitter A] Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Prieto JC] Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA. [Ruggieri S] Department of Human Neurosciences, 'Sapienza' University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Department of Neurosciences, San Camillo Forlanini Hospital, Circonvallazione Gianicolense, 87, 00152 Roma RM, Italy. [Pareto D] Secció de Neuroradiologia, Unitat de Ressonància Magnètica, Departament de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sastre-Garriga J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Burggraaff, J., Liu, Y., Prieto, J. C., Simoes, J., de Sitter, A., Ruggieri, S., Brouwer, I., Lissenberg-Witte, B. I., Rocca, M. A., Valsasina, P., Ropele, S., Gasperini, C., Gallo, A., Pareto, D., Sastre-Garriga, J., Enzinger, C., Filippi, M., De Stefano, N., Ciccarelli, O., Hulst, H. E., Wattjes, M. P., Barkhof, F., Uitdehaag, B. M. J., Vrenken, H., Guttmann, C. R. G. |
| المصدر: | NeuroImage: Clinical, 29:102549. Elsevier BV Burggraaff, J, Liu, Y, Prieto, J C, Simoes, J, de Sitter, A, Ruggieri, S, Brouwer, I, Lissenberg-Witte, B I, Rocca, M A, Valsasina, P, Ropele, S, Gasperini, C, Gallo, A, Pareto, D, Sastre-Garriga, J, Enzinger, C, Filippi, M, de Stefano, N, Ciccarelli, O, Hulst, H E, Wattjes, M P, Barkhof, F, Uitdehaag, B M J, Vrenken, H & Guttmann, C R G 2021, ' Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study ', NeuroImage: Clinical, vol. 29, 102549 . https://doi.org/10.1016/j.nicl.2020.102549Test Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona NeuroImage : Clinical NeuroImage. Clinical, Vol. 29, no. 1, p. 102549 [1-12] (2021) Scientia NeuroImage: Clinical, Vol 29, Iss, Pp 102549-(2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | WLG, Word List Generation, SPM12, Statistical Parametric Mapping 12, Audiology, Tàlem - Imatgeria, Etiv, estimated total intracranial volume, lcsh:RC346-429, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], GIF, Geodesic Information Flows, 0302 clinical medicine, Cognition, Segmentation, Thalamus, CP, cognitively preserved, NBV, Normalized brain volume, Multiple Sclerosi, Other subheadings::/diagnosis [Other subheadings], Neuropsychological assessment, Cognitive decline, Generalized estimating equation, WMV, white matter volume, ICC, intraclass correlation coefficient, medicine.diagnostic_test, 05 social sciences, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], sistema nervioso::sistema nervioso central::encéfalo::prosencéfalo::diencéfalo::tálamo [ANATOMÍA], Regular Article, Neuropsychological test, HC, healthy control, SDMT, Symbol Digit Modalities Test, Magnetic Resonance Imaging, Neurology, PASAT, Paced Auditory Serial Addition Test, enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], lcsh:R858-859.7, VolBrain, MRI Brain Volumetry System, SRT, Selective Reminding Test, Human, MRI, Esclerosi múltiple - Complicacions, medicine.medical_specialty, CNR, contrast-to-noise ratio, Multiple Sclerosis, Cognitive Neuroscience, RRMS, Relapsing-Remitting Multiple Sclerosis, Otros calificadores::/diagnóstico [Otros calificadores], Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Thalamus [ANATOMY], 10/36 SRT, 10/36 Spatial Recall Test, lcsh:Computer applications to medicine. Medical informatics, NGMV, Normalized grey matter volume, 050105 experimental psychology, SD, standard deviations, CII, cognitive impairment index, EDSS, Expanded Disability Status Scale, WCST, Wisconsin Card Sorting Test, 03 medical and health sciences, Atrophy, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, WM, white matter, lcsh:Neurology. Diseases of the nervous system, Thalamu, CI, cognitively impaired and preserved (CP), BRB-N, Brief Repeatable Battery of Neuropsychological Tests, business.industry, Multiple sclerosis, FSL-FIRST, FMRIB Integrated Registration and Segmentation Tool, eTIV, estimated total intracranial volume, CAT12, Computational Anatomy Toolbox for Statistical Parametric Mapping 12, GM, grey matter, medicine.disease, Deep grey matter, NWMV, Normalized white matter volume, MS, Multiple Sclerosis, GMV, grey matter volume, IPS, information processing speed, Neurology (clinical), business, 030217 neurology & neurosurgery, Other subheadings::Other subheadings::/complications [Other subheadings] |
| الوصف: | Highlights • Thalamus atrophy is associated with cognitive impairment in multiple sclerosis. • This was confirmed by automated and manual segmentations, but effect sizes varied. • The algorithms work in a multi-center setting. • Automated techniques exhibit proportional bias with respect to thalamus size. • Differences between vendors can affect the robustness of these associations. Background and rationale Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain MRI were collected (multi-center) from 57 MS patients and 17 healthy controls. Thalamus segmentations were generated manually and using five automated methods. Agreement between the algorithms and manual outlines was assessed with Bland-Altman plots; linear regression assessed the presence of proportional bias. The effect of segmentation method on the separation of cognitively impaired (CI) and preserved (CP) patients was investigated through Generalized Estimating Equations; associations with cognitive measures were investigated using linear mixed models, for each method and vendor. Results In smaller thalami, automated methods systematically overestimated volumes compared to manual segmentations [ρ=(-0.42)-(-0.76); p-values |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4050b09dc6d0ff6de624197073c5fcdaTest https://doi.org/10.1016/j.nicl.2020.102549Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4050b09dc6d0ff6de624197073c5fcda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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