المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668aTest
http://www.sciencedirect.com/science/article/pii/S2211383521000113Test

المؤلفون: Janice Mayne, Francine Sirois, Michel Chrétien, Majambu Mbikay, Sonia Simoes

المصدر: FEBS Open Bio, Vol 4, Iss C, Pp 755-762 (2014)
FEBS Open Bio

مصطلحات موضوعية: HMGCoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, medicine.medical_specialty, Low-density lipoprotein receptor gene family, 030204 cardiovascular system & hematology, Article, Q3G, quercetin-3-β-d-glucoside, SREBP-2, sterol regulatory element-binding protein 2, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, heterocyclic compounds, LDL-C, low-density lipoprotein-cholesterol, ApoB, apolipoprotein B, Low-density lipoprotein receptor, lcsh:QH301-705.5, TGN, trans Golgi network, 030304 developmental biology, 0303 health sciences, PCSK9, proprotein convertase subtilisin/kexin 9, biology, Cholesterol, PCSK9, fungi, nutritional and metabolic diseases, food and beverages, Proprotein convertase, Sortilin, ABCA1, ATP-binding cassette transporter A1, 3. Good health, Endocrinology, chemistry, lcsh:Biology (General), LDLR, low-density lipoprotein receptor, ABCA1, LDL receptor, biology.protein, Hepatocytes, Kexin, lipids (amino acids, peptides, and proteins), Quercetin, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87f6b700221cf8c6a3f7779a511f3beTest