أعرض في EDS

Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water

التفاصيل البيبلوغرافية
العنوان: Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water
المؤلفون: Benjamin Hansen, Nancy D. Denslow, Marvin A. Friedman, Reyna Cristina Colli-Dula
المصدر: Toxicology Reports
Toxicology Reports, Vol 3, Iss, Pp 414-426 (2016)
بيانات النشر: Elsevier BV, 2016.
سنة النشر: 2016
مصطلحات موضوعية: PRODH, proline dehydrogenase, VWF, Von Willebrand Factor, CCNG1, cyclin G1, CCNA2, cyclin A2, CDCA2, cell division cycle associated 2, Toxicology, ID1, inhibitor of DNA binding 1, MIF, macrophage migration inhibitory factor, HPSE, heparanase, TPO, thyroid peroxidase, NUBP1, nucleotide binding protein 1, RAN, ras-related nuclear protein, ADA, adenosine Deaminase, Thyroid, CD46, CD46 molecule, TSN, translin, PTGS1, prostaglandin-endoperoxide synthase 1, PLK1, polo-like kinase 1, PINK1, PTEN induced putative kinase 1, Acrylamide, ADRB2, adrenergic, medicine.medical_specialty, KIF20B, kinesin family member 20B, TSHR, thyroid stimulating hormone receptor, Follicular cell, Article, BRIP1, BRCA1 Interacting Protein C-Terminal Helicase 1, 03 medical and health sciences, CDCA5, cell division cycle associated 5, GOLGA3, golgin A3, Transcriptomics, C5, complement Component 5, GCG, glucagon, lcsh:Toxicology. Poisons, DAD1, defender against cell death 1, DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha, CFB, complement factor B, NPPC, natriuretic peptide precursor C, PRL, prolactin, CD45, protein tyrosine phosphatase, Prolactin, CTLA4, cytotoxic T-lymphocyte-associated protein 4, 030104 developmental biology, Endocrinology, chemistry, LAMA2, laminin, alpha 2, SCL5A5, solute carrier family 5 (sodium iodide symporter), MCM8, minichromosome maintenance complex component 8, Hormone, 0301 basic medicine, HSPB1, heat shock 27 KDa protein, NPY, neuropeptide, TACC3, transforming, Health, Toxicology and Mutagenesis, TFRC, transferrin receptor, KLK1, kallikrein 1, TBCB, tubulin folding cofactor B, medicine.disease_cause, DCTPP1, DCTP pyrophosphatase 1, PDE3A, phosphodiesterase 3A, chemistry.chemical_compound, RAB5A, RAB5A, KIF22, kinesin family Member 22, MIS18A, MIS18 kinetochore protein A, SPAG8, sperm associated antigen 8, HSPA5, heat shock 70 kDa protein 5, TOP2A, topoisomerase (DNA) II alpha, Triiodothyronine, PTGIS, prostaglandin I2 (prostacyclin) synthase, C1QTNF3, C1q and Tumor Necrosis Factor Related Protein 3, HTATIP2, HIV-1 tat interactive protein 2, NDC80, NDC80 kinetochore complex component, INHBA, inhibin, medicine.anatomical_structure, RccHan Wistar, CARD9, caspase recruitment domain family, IL1B, interleukin 1, Sample collection, PLCD1, phospholipase C, CDC45, cell division cycle 45, Biology, GSTP1, glutathione S-transferase Pi 1, IGF2, Insulin-like growth factor 2 (somatomedin A), POMC, proopiomelanocortin, SELP, selectin P (granule membrane protein 140 kDa, lcsh:RA1190-1270, Internal medicine, medicine, ORC1, origin recognition complex, DUOX2, dual oxidase 2, RRM2, ribonucleotide reductase M2, IYD, iodotyrosine deiodinase, CENPT, centromere protein T, GCLC, glutamate-cysteine ligase, HSPH1, heat shock 105 kDa/110 kDa protein 1, BUB1B, BUB1 Mitotic Checkpoint Serine/Threonine Kinase B, CGA, glycoprotein hormones, HSPB2, heat shock 27 kDa protein 2, PRKAA2, protein kinase, ASF1B, anti-Silencing Function 1B Histone Chaperone, GSTM1, glutathione S-transferase Mu 1, CALCR, calcitonin receptor, Oxidative stress
الوصف: Acrylamide is known to produce follicular cell tumors of the thyroid in rats. RccHan Wistar rats were exposed in utero to a carcinogenic dose of acrylamide (3 mg/Kg bw/day) from gestation day 6 to delivery and then through their drinking water to postnatal day 35. In order to identify potential mechanisms of carcinogenesis in the thyroid glands, we used a transcriptomics approach. Thyroid glands were collected from male pups at 10 PM and female pups at 10 AM or 10 PM in order to establish whether active exposure to acrylamide influenced gene expression patterns or pathways that could be related to carcinogenesis. While all animals exposed to acrylamide showed changes in expected target pathways related to carcinogenesis such as DNA repair, DNA replication, chromosome segregation, among others; animals that were sacrificed while actively drinking acrylamide-laced water during their active period at night showed increased changes in pathways related to oxidative stress, detoxification pathways, metabolism, and activation of checkpoint pathways, among others. In addition, thyroid hormones, triiodothyronine (T3) and thyroxine (T4), were increased in acrylamide-treated rats sampled at night, but not in quiescent animals when compared to controls. The data clearly indicate that time of day for sample collection is critical to identifying molecular pathways that are altered by the exposures. These results suggest that carcinogenesis in the thyroids of acrylamide treated rats may ensue from several different mechanisms such as hormonal changes and oxidative stress and not only from direct genotoxicity, as has been assumed to date. Keywords: Acrylamide, RccHan Wistar, Transcriptomics, Thyroid
تدمد: 2214-7500
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e12b08f21dfc658b4cacd91f9295efTest
https://doi.org/10.1016/j.toxrep.2016.03.009Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....e4e12b08f21dfc658b4cacd91f9295ef
قاعدة البيانات: OpenAIRE
الوصف
تدمد:22147500