المؤلفون: Neuvonen, Mikko, Hirvensalo, Päivi, Tornio, Aleksi, Rago, Brian, West, Mark, Lazzaro, Sarah, Mathialagan, Sumathy, Varma, Manthena, Cerny, Matthew A., Costales, Chester, Ramanathan, Ragu, Rodrigues, A. David, Niemi, Mikko

المساهمون: HUSLAB, Department of Clinical Pharmacology, Department of Diagnostics and Therapeutics, University of Helsinki, Helsinki University Hospital Area, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Medicum

مصطلحات موضوعية: ANION TRANSPORTING POLYPEPTIDE, POLYMORPHISM MARKEDLY AFFECTS, SLCO1B1 POLYMORPHISM, ENDOGENOUS BIOMARKERS, HAPLOTYPE RECONSTRUCTION, PLASMA-CONCENTRATIONS, CYNOMOLGUS MONKEYS, DRUG-INTERACTION, GENOME-WIDE, BILE-ACIDS, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: This study was supported by grants from the European Research Council (Grant agreement 282109), State Funding for University-level Health Research (Finland), and the Sigrid Juselius Foundation (Helsinki, Finland), and funding from Pfizer Inc (Groton, Connecticut, USA).; Neuvonen , M , Hirvensalo , P , Tornio , A , Rago , B , West , M , Lazzaro , S , Mathialagan , S , Varma , M , Cerny , M A , Costales , C , Ramanathan , R , Rodrigues , A D & Niemi , M 2021 , ' Identification of Glycochenodeoxycholate 3-O-glucuronide and Glycodeoxycholate 3-O-glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers ' , Clinical Pharmacology and Therapeutics , vol. 109 , no. 3 , pp. 646-657 . https://doi.org/10.1002/cpt.2053Test; ORCID: /0000-0001-5713-5692/work/127003692; 5baa484e-cb9d-4086-ad52-95681cf4ea48; http://hdl.handle.net/10138/353214Test; 000578988500001

الإتاحة: http://hdl.handle.net/10138/353214Test

المؤلفون: Kiander, Wilma, Sjostedt, Noora, Manninen, Riikka, Jaakkonen, Liina, Vellonen, Kati-Sisko, Neuvonen, Mikko, Niemi, Mikko, Auriola, Seppo, Kidron, Heidi

المساهمون: Division of Pharmaceutical Biosciences, Drug Delivery Unit, Department of Clinical Pharmacology, HUSLAB, Medicum, Drug Research Program

مصطلحات موضوعية: Pharmacogenetics, Rosuvastatin, Pharmacokinetics, Simulation, Proteomics, SLCO1B1 POLYMORPHISM, TRANSPORT ACTIVITY, DRUG TRANSPORTERS, HEPATIC-UPTAKE, C SLC21A6, EXPRESSION, VARIANTS, QUANTIFICATION, METAANALYSIS, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: We are grateful for the funding provided by Svenska Kulturfonden, Medicinska Understodsforeningen for Liv och Halsa, DRA Consultingoy, Instrumentarium Science Foundation, Finnish Cultural Foundation, Sigrid Juselius Foundation and the European Research Council (Grant Agreement 725,249). The UEF Metabolomics laboratory is supported by Biocenter Finland and Biocenter Kuopio; Kiander , W , Sjostedt , N , Manninen , R , Jaakkonen , L , Vellonen , K-S , Neuvonen , M , Niemi , M , Auriola , S & Kidron , H 2022 , ' Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function ' , European Journal of Pharmaceutical Sciences , vol. 176 , 106246 . https://doi.org/10.1016/j.ejps.2022.106246Test; ORCID: /0000-0001-6427-8042/work/116874680; ORCID: /0000-0001-9523-7139/work/116875052; ORCID: /0000-0001-6960-7757/work/127505260; 85133913115; 359ef7ce-f362-44b3-8e56-b19fecc4cbbe; http://hdl.handle.net/10138/346696Test; 000829288900005

الإتاحة: http://hdl.handle.net/10138/346696Test

المؤلفون: Kiander, Wilma, Vellonen, Kati-Sisko, Malinen, Melina M., Gynther, Mikko, Hagström, Marja, Bhattacharya, Madhushree, Auriola, Seppo, Koenderink, Jan B., Kidron, Heidi

المساهمون: Divisions of Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Drug Delivery Unit, Drug Research Program

مصطلحات موضوعية: TRANSPORTING POLYPEPTIDE 1B1, SLCO1B1 POLYMORPHISM, INDUCED MYOPATHY, C SLC21A6, VARIANTS, EXPRESSION, DRUG, PHARMACOKINETICS, IDENTIFICATION, SUPERFAMILY, 116 Chemical sciences, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: We are grateful for the funding provided by Svenska Kulturfonden, Medicinska Understodsforeningen for Liv och Halsa, DRA Consulting oy, Instrumentarium Science Foundation and Finnish Cultural Foundation. The UEF Metabolomics laboratory is supported by Biocenter Finland and Biocenter Kuopio and the Drug Discovery and Chemical Biology Network and the Light Microscopy Unit are funded by Biocenter Finland. Dr. Melina M. Malinen received funding from the European Union's Horizon 2020 Research and Innovation program under the Marie Sklodowska-Curie grant agreement number 799510.; Kiander , W , Vellonen , K-S , Malinen , M M , Gynther , M , Hagström , M , Bhattacharya , M , Auriola , S , Koenderink , J B & Kidron , H 2021 , ' The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality ' , Pharmaceutical Research , vol. 38 , no. 10 , pp. 1663-1675 . https://doi.org/10.1007/s11095-021-03107-8Test; ORCID: /0000-0001-6427-8042/work/104152693; ORCID: /0000-0001-9523-7139/work/104153235; 85117007239; 86d3f694-006f-4929-90f8-3ce6377d70f8; http://hdl.handle.net/10138/337027Test; 000706919900001

الإتاحة: http://hdl.handle.net/10138/337027Test

المؤلفون: Mukonzo, JK, Kengo, A, Kutesa, B, Nanzigu, S, Pohanka, A, McHugh, TD, Zumla, A, Aklillu, E

المصدر: Transactions of The Royal Society of Tropical Medicine and Hygiene , 114 (2) pp. 107-114. (2020)

مصطلحات موضوعية: SLCO1B1 polymorphism, multidrug-resistant TB, pharmacokinetics, rifampicin, sub-Saharan Africa, treatment outcomes

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10089291/3/McHugh_Mukonzo%20et%20al%202019.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10089291Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10089291/3/McHugh_Mukonzo%20et%20al%202019.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10089291Test/

المؤلفون: Iwaki, Yuki, Lee, Wooin, Sugiyama, Yuichi

المساهمون: Lee, Wooin

مصطلحات موضوعية: COA REDUCTASE INHIBITORS, DRUG-DRUG INTERACTIONS, LIPOPROTEIN-CHOLESTEROL REDUCTION, SIMVASTATIN ACID, PLASMA-CONCENTRATIONS, HEALTHY CHINESE, SLCO1B1 POLYMORPHISM, ABCG2 POLYMORPHISM, HEPATIC-CLEARANCE, SKELETAL-MUSCLE, Dose-response relationship, exposure-response relationship, extended clearance concept, In-vitro-in-vivo extrapolation, model-based meta-analysis, statin, transporter

العلاقة: Expert Opinion on Drug Metabolism and Toxicology, Vol.15 No.11, pp.897-911; https://hdl.handle.net/10371/190098Test; 000494999800001; 2-s2.0-85074859689; 95090

الإتاحة: https://doi.org/10.1080/17425255.2019.1681399Test
https://hdl.handle.net/10371/190098Test

المؤلفون: Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Tapaninen, Tuija, Paile-Hyvärinen, Maria, Kärjä, Vesa, Männistö, Ville T., Pihlajamäki, Jussi, Backman, Janne T., Niemi, Mikko

المساهمون: Medicum, Department of Clinical Pharmacology, University of Helsinki, Janne Backman / Principal Investigator, Clinicum, HUSLAB

مصطلحات موضوعية: REDUCED PLASMA-CONCENTRATIONS, DRUG-DRUG INTERACTIONS, RECEPTOR ANTAGONIST, GLUCURONOSYLTRANSFERASE UGT1A3, NONALCOHOLIC STEATOHEPATITIS, HAPLOTYPE RECONSTRUCTION, SLCO1B1 POLYMORPHISM, CYP2C8 GENOTYPE, COMMON VARIANT, BODY-SURFACE, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Hirvensalo , P , Tornio , A , Neuvonen , M , Tapaninen , T , Paile-Hyvärinen , M , Kärjä , V , Männistö , V T , Pihlajamäki , J , Backman , J T & Niemi , M 2018 , ' Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics ' , Clinical Pharmacology and Therapeutics , vol. 104 , no. 1 , pp. 158-168 . https://doi.org/10.1002/cpt.891Test; ORCID: /0000-0002-9577-2788/work/47012288; ORCID: /0000-0001-5713-5692/work/47013614; 85048561913; f2f00970-59ac-4495-a4fb-cc7280e5bfb0; http://hdl.handle.net/10138/237263Test; 000434960300031

الإتاحة: http://hdl.handle.net/10138/237263Test

المؤلفون: Nies, Anne T., Niemi, Mikko, Burk, Oliver, Winter, Stefan, Zanger, Ulrich M., Stieger, Bruno, Schwab, Matthias, Schaeffeler, Elke

المساهمون: Haartman Institute (-2014), Clinicum, Department of Diagnostics and Therapeutics

مصطلحات موضوعية: HEPATOCYTE NUCLEAR FACTOR-1-ALPHA, POLYMORPHISM MARKEDLY AFFECTS, FARNESOID X RECEPTOR, HUMAN LIVER, HEPATOCELLULAR-CARCINOMA, C SLC21A6, HEPATOBILIARY TRANSPORT, SLCO1B1 POLYMORPHISM, SECONDARY STRUCTURE, FUNCTIONAL-ANALYSIS, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We gratefully acknowledge Dr Peter Fritz, chief pathologist at the Robert-Bosch-Hospital, for expert histological examination of all liver samples, Dr Kathrin Klein for providing selected SLCO microarray data and Rabea Riedel for help in generating OATP2B1 transfectants. We greatly appreciate the expert technical help of Silvia Hubner, Ursula Waldherr, Monika Elbl, Heidi Kohler, and Igor Liebermann. This work was supported by the Robert Bosch Foundation (Stuttgart, Germany), the Federal Ministry for Education and Research (BMBF, Berlin, Germany) grant 03 IS 2061C and 0315755, the FP7-grant PITN-GA-2009-238132, and the Sigrid Juselius Foundation (Helsinki, Finland).; Nies , A T , Niemi , M , Burk , O , Winter , S , Zanger , U M , Stieger , B , Schwab , M & Schaeffeler , E 2013 , ' Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 ' , Genome medicine , vol. 5 . https://doi.org/10.1186/gm405Test; 84872149285; 0de6d1b1-2282-4f93-b017-53ef6da37f85; http://hdl.handle.net/10138/166578Test; 000318905500001

الإتاحة: http://hdl.handle.net/10138/166578Test

المؤلفون: Wilma Kiander, Noora Sjöstedt, Riikka Manninen, Liina Jaakkonen, Kati-Sisko Vellonen, Mikko Neuvonen, Mikko Niemi, Seppo Auriola, Heidi Kidron

المساهمون: Division of Pharmaceutical Biosciences, Drug Delivery Unit, Department of Clinical Pharmacology, HUSLAB, Medicum, Drug Research Program

المصدر: European Journal of Pharmaceutical Sciences. 176:106246

مصطلحات موضوعية: Proteomics, EXPRESSION, TRANSPORT ACTIVITY, Liver-Specific Organic Anion Transporter 1, C SLC21A6, Organic Anion Transporters, Pharmaceutical Science, DRUG TRANSPORTERS, VARIANTS, QUANTIFICATION, HEPATIC-UPTAKE, Rosuvastatin, HEK293 Cells, Pharmacogenetics, 317 Pharmacy, Tandem Mass Spectrometry, SLCO1B1 POLYMORPHISM, Humans, Pharmacokinetics, Rosuvastatin Calcium, Simulation, METAANALYSIS, Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253b723161212c0c91603877642555f9Test
https://doi.org/10.1016/j.ejps.2022.106246Test

المؤلفون: Ooi, Brandon NS, Raechell, Ying, Ariel F, Koh, Yong Zher, Jin, Yu, Yee, Sherman WL, Lee, Justin HS, Chong, Samuel S, Tan, Jack WC, Liu, Jianjun, Lee, Caroline G, Drum, Chester L

المساهمون: DEPT OF BIOCHEMISTRY, DEPT OF MEDICINE, DEPT OF PAEDIATRICS, DUKE-NUS MEDICAL SCHOOL, LEE KUAN YEW SCHOOL OF PUBLIC POLICY, NUS GRADUATE SCHOOL

المصدر: Elements

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, statin, myalgia, whole genome sequencing, machine learning, pharmacogenomics, STATIN-INDUCED MYOPATHY, SLCO1B1 POLYMORPHISM, GENETIC VARIANT, ASSOCIATION, ADHERENCE, THERAPY, RISK, GENERATION, EXPRESSION, SINGAPORE

العلاقة: Ooi, Brandon NS, Raechell, Ying, Ariel F, Koh, Yong Zher, Jin, Yu, Yee, Sherman WL, Lee, Justin HS, Chong, Samuel S, Tan, Jack WC, Liu, Jianjun, Lee, Caroline G, Drum, Chester L (2021-04-22). Robust Performance of Potentially Functional SNPs in Machine Learning Models for the Prediction of Atorvastatin-Induced Myalgia. FRONTIERS IN PHARMACOLOGY 12. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2021.605764Test; https://scholarbank.nus.edu.sg/handle/10635/226803Test

الإتاحة: https://doi.org/10.3389/fphar.2021.605764Test
https://scholarbank.nus.edu.sg/handle/10635/226803Test

المؤلفون: Wilma Kiander, Mikko Gynther, Kati-Sisko Vellonen, Madhushree Bhattacharya, Heidi Kidron, Melina M. Malinen, Seppo Auriola, Marja Hagström, Jan B. Koenderink

المساهمون: Divisions of Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Drug Delivery Unit, Drug Research Program

المصدر: Pharmaceutical Research, 38, 10, pp. 1663-1675
Pharmaceutical Research, 38, 1663-1675
Pharmaceutical Research

مصطلحات موضوعية: PHARMACOKINETICS, 116 Chemical sciences, C SLC21A6, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Gene Expression, Pharmaceutical Science, VARIANTS, Proteomics, 030226 pharmacology & pharmacy, 0302 clinical medicine, Tandem Mass Spectrometry, Drug Interactions, Pharmacology (medical), Rosuvastatin Calcium, DRUG, Cellular localization, 0303 health sciences, biology, Liver-Specific Organic Anion Transporter 1, Nucleotides, Chemistry, SUPERFAMILY, Organic anion-transporting polypeptide, Transmembrane domain, Liver, Biochemistry, 317 Pharmacy, Molecular Medicine, Research Paper, Biotechnology, EXPRESSION, TRANSPORTING POLYPEPTIDE 1B1, INDUCED MYOPATHY, 03 medical and health sciences, SLCO1B1 POLYMORPHISM, Humans, Gene, 030304 developmental biology, Pharmacology, Polymorphism, Genetic, IDENTIFICATION, Organic Chemistry, HEK 293 cells, Wild type, Biological Transport, Isoquinolines, In vitro, HEK293 Cells, Mutation, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ec5a3cafa9fa7a792eb27bf4691d5eTest