التفاصيل البيبلوغرافية
| العنوان: |
PLLA Porous Microsphere-Reinforced Silk-Based Scaffolds for Auricular Cartilage Regeneration |
| المؤلفون: |
Yan Zeng (120271), Xiaokai Li (1722154), Xia Liu (117318), Yuzhou Yang (10030330), Zhimin Zhou (7295960), Jincai Fan (10030333), Haiyue Jiang (4845502) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Biotechnology, Ecology, Plant Biology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, SBH scaffolds, PLLA PMs, PLLA Porous Microsphere-Reinforced ., auricular cartilage tissue engineering, Auricular Cartilage Regeneration Mi., plastic surgery practice, PSB, novel poly-l-lactic acid, degummed silk fiber mesh, SF, cartilage tissue engineering |
| الوصف: |
Microtia, frequently encountered in plastic surgery practice, is usually corrected by auricular reconstruction with prostheses or autologous cartilages. In recent decades, however, cartilage tissue engineering has been emerging as a promising alternative for its minimal invasion and low immunogenicity. As a critical factor for tissue engineering, scaffolds are expected to be sufficiently porous and stiff to facilitate chondrogenesis. In this work, we introduce novel poly-l-lactic acid (PLLA) porous microsphere-reinforced silk-based hybrid (SBH) scaffolds with a multihierarchical porous structure. The scaffolds are fabricated by embedding PLLA porous microspheres (PMs) into a blending matrix of silk fibroin (SF) and gelatin solution, followed by mixing with a degummed silk fiber mesh and freeze-drying process. Through adjusting the amount of PLLA PMs, the mechanical strength approximates to natural cartilage and also balanced physical properties were realized. Biological evaluations of SBH scaffolds, both in vitro and in vivo, were conducted and PM-free plain silk-based (PSB) scaffolds were applied as control. Overall, it suggests that the incorporation of PLLA PMs remarkably improves mechanical properties and the capability to promote chondrogenesis of SBH scaffolds, and that SBH scaffolds appear to be a promising construct for potential applications in auricular cartilage tissue engineering and relevant fields. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/PLLA_Porous_Microsphere-Reinforced_Silk-Based_Scaffolds_for_Auricular_Cartilage_Regeneration/13637074Test |
| DOI: |
10.1021/acsomega.0c05890.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsomega.0c05890.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.D9FA6B71 |
| قاعدة البيانات: |
BASE |
