المؤلفون: Jian-Guang Luo, Tianyu Zhu, Chen Chen, Yi Zhang, Hao Zhang, Dong-Rong Zhu, Xiao-Qin Liu, Ling-Yi Kong, Chao Han, Sifang Wu

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 246-261 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PHGDH, phosphoglycerate dehydrogenase, PSAT, phosphoserine aminotransferase, Allosteric regulation, CuAAC, copper-catalyzed alkyne–azide cycloaddition, Regulatory site, ABPP, affinity-based protein profiling, RM1-950, Proteomics, RMSD, root mean square deviation, Serine, CETSA, cellular thermal shift assay, 03 medical and health sciences, 3-PHP, 3-phosphohydroxypyruvate, ROS, reactive oxygen species, 0302 clinical medicine, DARTS, drug affinity responsive target stability, TCEP, tris(2-carboxyethyl) phosphine, GSH, glutathione, TBTA, tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine, Phosphoglycerate dehydrogenase, General Pharmacology, Toxicology and Pharmaceutics, Covalent inhibitor, Withanolides, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemical proteomics, NADPH, nicotinamide adenine dinucleotide phosphate, Serine synthesis pathway, MD, molecular dynamics, Small molecule, 3-PG, 3-phosphoglycerate, Colon cancer, RMSF, root mean square fluctuations, Enzyme, chemistry, Biochemistry, Oxidative stress, SBD, substrate-binding domain, 030220 oncology & carcinogenesis, Original Article, BLI, biolayer interferometry assay, Therapeutics. Pharmacology, SSP, serine synthesis pathway, Withangulatin A, Cysteine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543b6d3266f2b136393cdedb4c3da23Test
http://www.sciencedirect.com/science/article/pii/S2211383521002203Test

المؤلفون: Methinee Pipatthana, Surang Chankhamhaengdecha, Somsak Likhitrattanapisal, Tavan Janvilisri, Matthew Phanchana, Phurt Harnvoravongchai, Pisut Pongchaikul

المصدر: Computational and Structural Biotechnology Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2905-2920 (2021)

مصطلحات موضوعية: SP, Substrate-binding domain (SBD)-containing protein, Protein domain, Biophysics, ATP-binding cassette transporter, Computational biology, Biology, In silico analysis, Antimicrobial resistance, Biochemistry, Genome, 03 medical and health sciences, TP, Transmembrane protein, 0302 clinical medicine, Structural Biology, Genetics, NP, Nucleotide-binding domain (NBD)-containing protein, ABC transporter/protein, ATP-binding cassette transporter/protein, ECF-type transporter, Energy coupling factor-type transporter, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, 0303 health sciences, TMD, Transmembrane domain, SBD, Substrate-binding domain, Signal transducing adaptor protein, Computer Science Applications, Transmembrane domain, NBD, Nucleotide-binding domain, Membrane protein, 030220 oncology & carcinogenesis, Active transporter, ABC classification, Function (biology), TP248.13-248.65, Reference genome, Biotechnology, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e9053af190d87883dd74f55d18bd6dTest
http://europepmc.org/articles/PMC8144104Test

المؤلفون: Shu-ou Shan, Yumeng Liu, Hyunju Cho, Woo Jun Shim

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, tail-anchored protein, NBD, nucleotide binding domain, Saccharomyces cerevisiae Proteins, ATPase, TMD, transmembrane domain, membrane proteins, JDP, J-domain protein, Saccharomyces cerevisiae, SRP, signal recognition particle, Endoplasmic Reticulum, medicine.disease_cause, Biochemistry, Hsp70, 03 medical and health sciences, Protein targeting, protein targeting, medicine, HSP70 Heat-Shock Proteins, Molecular Biology, EV, empty vector, Signal recognition particle, Hsp40, TPR, tetratricopeptide repeat, 030102 biochemistry & molecular biology, biology, SBD, substrate binding domain, Chemistry, C-terminus, Cell Membrane, GET, guided entry of tail-anchored protein, Editors' Pick, Cell Biology, molecular chaperone, HSP40 Heat-Shock Proteins, CTD, C-terminal domain, SND, SRP-independent, Cell biology, Protein Transport, Tetratricopeptide, 030104 developmental biology, Membrane protein, Cyclic nucleotide-binding domain, biology.protein, Carrier Proteins, Biogenesis, Research Article, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9faa735b7e4cad00a3ec62a45a219fTest
https://resolver.caltech.edu/CaltechAUTHORS:20210317-150527513Test

المؤلفون: Vera Kovaleva, Richard Zimmermann, Mart Saarma, Maarit Hellman, Li-Ying Yu, Helka Göös, Päivi Lindholm, Perttu Permi, Ave Eesmaa, Kristofer Nõges, Martin Jung, Markku Varjosalo

المساهمون: Institute of Biotechnology, Molecular Systems Biology, Biosciences, Mart Saarma / Principal Investigator

المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, BiFC, bimolecular fluorescence complementation, MST, microscale thermophoresis, PDIA1, protein disulfide isomerase family A member 1, Apoptosis, NEUROTROPHIC FACTOR MANF, Endoplasmic Reticulum, Biochemistry, protein-protein interaction, Mice, Bimolecular fluorescence complementation, UPR, unfolded protein response, ENDOPLASMIC-RETICULUM STRESS, Mesencephalon, Neurotrophic factors, Insulin-Secreting Cells, Protein Interaction Mapping, BINDING, COMPREHENSIVE RESOURCE, ATF6, unfolded protein response (UPR), PDIA6, protein disulfide isomerase family A member 6, PPIs, protein-protein interactions, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, NPTN, neuroplastin, biology, Chemistry, apoptosis, unfolded protein response, dopamine neurons, 3. Good health, Cell biology, GDNF, glial cell line–derived neurotrophic factor, IRE1-ALPHA, SBD, substrate-binding domain, endoplasmic reticulum stress, MANF, mesencephalic astrocyte-derived neurotrophic factor, Tm, tunicamycin, neuroprotection, Research Article, Protein Binding, Signal Transduction, GRP78, Protein Disulfide-Isomerase Family, Cell Survival, TH, tyrosine hydroxylase, Primary Cell Culture, SCG, superior cervical ganglion, Protein Disulfide-Isomerases, IRE1, inositol-requiring enzyme 1, ER-STRESS, ER, endoplasmic reticulum, 03 medical and health sciences, ohjelmoitunut solukuolema, C-MANF, C-terminal domain of MANF, CSPs, chemical shift perturbations, Animals, Humans, HSP70 Heat-Shock Proteins, Nerve Growth Factors, NBD, nucleotide-binding domain, NMR, nuclear magnetic resonance, Molecular Biology, 030102 biochemistry & molecular biology, BIP, Dopaminergic Neurons, Gene Expression Profiling, Binding protein, neuronal cell death, DISSOCIATION, Cell Biology, NEI, nucleotide exchange inhibitor, Embryo, Mammalian, adenosiinitrifosfaatti, ATP, hermosolut, mesencephalic astrocyte-derived neurotrophic factor, protein–protein interaction, PERK, protein kinase RNA-like ER kinase, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, Chaperone (protein), Tg, thapsigargin, biology.protein, Unfolded protein response, AP-MS, affinity purification mass spectrometry, 1182 Biochemistry, cell and molecular biology, GFP-SH, SH-tagged GFP, endoplasmic reticulum stress (ER stress), DA, dopamine, mesencephalic astrocyte-derived neurotrophic factor (MANF), proteiinit, Neuroplastin

وصف الملف: application/pdf; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ba32ad4a5ccd78db57615fd60c668Test
http://urn.fi/URN:NBN:fi:jyu-202102221722Test

المؤلفون: Hrithik Praveen, Yiming Zhang, Rory A. Greer, Yuhua Song, Yuwei Song

المصدر: European Journal of Pharmaceutical Sciences

مصطلحات موضوعية: Models, Molecular, NBD, nucleotide binding domain, Protein Conformation, Drug repurposing, Pharmaceutical Science, 02 engineering and technology, Pharmacology, PGE2, Prostaglandin E2, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, S protein, spike protein, COVID-19 / SARS-CoV-2, media_common, COVID-19, coronavirus disease 2019, Molecular Structure, SBD, substrate binding domain, BiP, binding immunoglobulin protein, 021001 nanoscience & nanotechnology, Duvelisib, NK-1R, neurokinin-1 receptor, Drug repositioning, ARS, acute respiratory syndrome, HCV, hepatitis C virus, Molecular docking, HSP, heat shock protein, 0210 nano-technology, Drug, BiP, media_common.quotation_subject, In silico, Immunoglobulins, Virus Attachment, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, Article, ER, endoplasmic reticulum, 03 medical and health sciences, Structure-Activity Relationship, PDB, Protein Data Bank, Netupitant, MOA, mechanism of action, RdRp, RNA-dependent RNA polymerase, SARS-CoV-2, Drug Repositioning, Membrane Proteins, EP4, PGE2 receptor protein subtype 4, Virus Internalization, csBiP, cell surface BiP, chemistry, Viral replication, Docking (molecular), Paritaprevir

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff682ee399a7f2cb736647a22b9c519cTest
https://pubmed.ncbi.nlm.nih.gov/33617948Test

المؤلفون: Cory M. Nadel, Jason E. Gestwicki, Arielle Shkedi, Taylor Arhar

المصدر: The Journal of biological chemistry, vol 297, iss 5
The Journal of Biological Chemistry

مصطلحات موضوعية: Protein Folding, Biochemistry & Molecular Biology, nuclear magnetic resonance (NMR), Protein Conformation, PPI, protein–protein interaction, 1.1 Normal biological development and functioning, PPD, peptidyl-prolyl-cis/trans isomerase domain, JDP, J-domain protein, protein–protein interactions, Computational biology, Protein aggregation, Hsp27, heat shock protein 27, Medical and Health Sciences, Biochemistry, protein aggregation, Protein–protein interaction, Underpinning research, protein folding, TF, trigger factor, Humans, chaperone, Directionality, RNC, ribosome-nascent-chain, NBD, nucleotide-binding domain, NMR, nuclear magnetic resonance, Molecular Biology, biology, Trigger factor, Chemistry, JBC Reviews, RBD, ribosome-binding domain, Cell Biology, Biological Sciences, Folding (chemistry), nuclear magnetic resonance, protein–protein interactions (PPIs), Cyclic nucleotide-binding domain, SBD, substrate-binding domain, Chaperone (protein), Chemical Sciences, biology.protein, Protein folding, PTM, posttranslational modification, Generic health relevance, sHsp, small heat shock protein, Molecular Chaperones, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b890469a9e8fdc14b702645f86d75b45Test
https://doi.org/10.1016/j.jbc.2021.101282Test

المؤلفون: Lei Zhou, Liqing Hu, Qingdai Liu, Hongtao Li, Qinglian Liu, Qianbin Li, Crist William Cuffee, Mahetab Mohamed

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Protein Folding, ATP, adenosine triphosphate, ATPase, Hsp70, heat shock protein 70 kDa, Allosteric regulation, Msi3, a multicopy suppressor of the heat shock-sensitive phenotype of the viral mutation, Protein aggregation, Biochemistry, Hsp70, chemistry.chemical_compound, Adenosine Triphosphate, Protein Domains, Sse1, stress seventy E1, Heat shock protein, Candida albicans, heat shock protein (HSP), HSP70 Heat-Shock Proteins, HSP110 Heat-Shock Proteins, NBD, nucleotide-binding domain, Molecular Biology, Heat-Shock Proteins, Adenosine Triphosphatases, Hsp110, Heat shock protein 110 kDa, Binding Sites, proteostasis, biology, Nucleotides, NEF, nucleotide-exchange factor, Hsp110, Cell Biology, molecular chaperone, allosteric regulation, ADP, adenosine diphosphate, Cell biology, Proteostasis, chemistry, Cyclic nucleotide-binding domain, SBD, substrate-binding domain, peptides, biology.protein, Protein folding, ATPase, adenosine triphosphatase, Adenosine triphosphate, Molecular Chaperones, Protein Binding, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ea860c54bed442341c06dafa26b414Test
https://doi.org/10.1016/j.jbc.2021.101082Test

المؤلفون: Kevin A. Morano, Unekwu M. Yakubu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Amyloid, Protein aggregation, Biochemistry, Hsp70, protein aggregation, Nucleotide exchange factor, Protein Aggregates, 03 medical and health sciences, PFF, preformed fibril, APP, amyloid precursor protein, iMAC, immobilized affinity chromatography, Amyloid precursor protein, medicine, chaperone, Animals, NBD, nucleotide-binding domain, HSP110 Heat-Shock Proteins, TEM, transmission electron microscopy, Molecular Biology, proteostasis, 030102 biochemistry & molecular biology, biology, Chemistry, Neurodegeneration, Hsp110, CS, citrate synthase, Cell Biology, ALS, amyotrophic lateral sclerosis, Htt, Huntingtin, medicine.disease, biology.organism_classification, Cell biology, Intrinsically Disordered Proteins, IDR, intrinsically disordered region, NEF, nucleotide exchange factor, 030104 developmental biology, Proteostasis, SBD, substrate-binding domain, Chaperone (protein), Parkinson’s disease, biology.protein, BSA, bovine serum albumin, Drosophila melanogaster, Alzheimer’s disease, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b47be0895abe6efe18be9fffb1a70bdTest
https://doi.org/10.1016/j.jbc.2021.100567Test

المؤلفون: Jean Paul Briand, Nicolas Page, Sylviane Muller, Christophe Macri, Nicolas Schall, Ana Maria Cuervo, Inmaculada Tasset, Fengjuan Wang

المساهمون: Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS), Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Autophagy
Autophagy, Taylor & Francis, 2015, 11 (3), pp.472-486. ⟨10.1080/15548627.2015.1017179⟩

مصطلحات موضوعية: Phosphopeptides, Mice, Inbred MRL lpr, LC-MS, liquid chromatography-mass spectrometry, NBD, nucleotide binding domain, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, T-Lymphocytes, Autoimmunity, CPZ: chlorpromazine, SLE, systemic lupus erythematosus, chemistry.chemical_compound, Mice, Chaperone-mediated autophagy, paraquat, 1, 1′-dimethyl-4, 4′-bipyridyldinium dichloride, qRT-PCR, quantitative reverse transcriptase-polymerase chain reaction, immune system diseases, Serine, Lupus Erythematosus, Systemic, antigen-presenting cells, ALF, artificial lysosomal fluid, RPL5, ribosomal protein L5, Phosphorylation, skin and connective tissue diseases, chaperone-mediated autophagy, HSPA8/HSC70, education.field_of_study, B-Lymphocytes, SBD, substrate binding domain, Sciences du Vivant [q-bio]/Biotechnologies, ELISA, enzyme-linked immunosorbent assay, MHCII, major histocompatibility complex class II, class II MHC molecules, Endocytosis, Basic Research Paper, CMA, chaperone-mediated autophagy, Cell biology, Lysosomal lumen, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, bodipy: BODIPY FL C5 Lactosylceramide/bovine serum albumin, LAMP2A, lysosomal-associated membrane protein 2A, RP-HPLC, reversed-phase high-performance liquid chromatography, autophagy, CTSD, cathepsin D, PBS, phosphate-buffered saline, Endosomes, Biology, SEM, standard error of the mean, Ribosomal protein L5, Ribonucleoprotein, U1 Small Nuclear, lysosomal chaperones, TFA, trifluoroacetic acid, Sequestosome 1, lysosomes, CoIP, coimmunoprecipitation, Downregulation and upregulation, Animals, Humans, education, Antigen-presenting cell, Molecular Biology, SQSTM1/p62, sequestosome 1, iv, intravenous, SNRNP70/U170K: small nuclear ribonucleoprotein 70kDa, Autophagy, HSC70 Heat-Shock Proteins, Histocompatibility Antigens Class II, Cell Biology, lupus, HCQ, hydroxychloroquine, LC3-II, MAP1LC3-II, Molecular biology, Peptide Fragments, TF, transferrin, chemistry, APC, antigen-presenting cell, Phosphoserine, heat shock proteins, NIH 3T3 Cells, FCS, fetal calf serum, SD, standard deviation, DAPI, 4′, 6-diamidino-2-phenylindole, Molecular Chaperones, B lymphocytes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3852162ef8e4c9b772246960eadd1bTest
https://hal.archives-ouvertes.fr/hal-02988901Test