دورية أكاديمية
Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-Tau in neuropathological stages of alzheimer’s disease
| العنوان: | Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-Tau in neuropathological stages of alzheimer’s disease |
|---|---|
| المؤلفون: | Bencze, János, Szarka, Máté, Bencs, Viktor, Szabó, Renáta Nóra, Módis, László V., Aarsland, Dag, Hortobágyi, Tibor |
| المصدر: | Bencze , J , Szarka , M , Bencs , V , Szabó , R N , Módis , L V , Aarsland , D & Hortobágyi , T 2020 , ' Lemur tyrosine kinase 2 (LMTK2) level inversely correlates with phospho-Tau in neuropathological stages of alzheimer’s disease ' , Brain Sciences , vol. 10 , no. 2 , 68 . https://doi.org/10.3390/brainsci10020068Test |
| سنة النشر: | 2020 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Digital image analysis, LMTK2, Neurodegeneration, SAlzheimer’s disease, Tau |
| الوصف: | Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. However, its expression pattern and association with the pathognomonic neurofibrillary tangles (NFTs) in different brain regions and neuropathological stages of AD is not clear. We performed chromogenic (CHR) LMTK2 and fluorescent phospho-tau/LMTK2 double-labelling (FDL) immunohistochemistry (IHC) on 10–10 postmortem middle frontal gyrus (MFG) and anterior hippocampus (aHPC) samples with early and late neuropathological Braak tau stages of AD. MFG in early stage was our ‘endogenous control’ region as it is not affected by NFTs. Semiquantitative CHR-IHC intensity scoring revealed significantly higher (p < 0.001) LMTK2 values in this group compared to NFT-affected regions. FDL- IHC demonstrated LMTK2 predominance in the endogenous control region, while phospho-tau overburden and decreased LMTK2 immunolabelling were detected in NFT-affected groups (aHPC in early and both regions in late stage). Spearman’s correlation coefficient showed strong negative correlation between phospho-tau/LMTK2 signals within each group. According to our results, LMTK2 expression is inversely proportionate to the extent of NFT pathology, and decreased LMTK2 level is not a general feature in AD brain, rather it is characteristic of the NFT-affected regions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/brainsci10020068 |
| الإتاحة: | https://doi.org/10.3390/brainsci10020068Test https://kclpure.kcl.ac.uk/portal/en/publications/0a87584b-50c7-4fa4-ae5c-7ae03b7f5323Test https://kclpure.kcl.ac.uk/ws/files/124308392/brainsci_10_00068.pdfTest http://www.scopus.com/inward/record.url?scp=85078993240&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1F07961 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/brainsci10020068 |
|---|